Detailed Peptide Information
This page shows detailed information of individual peptides present in PlantPepDB database. The page is majorly divided into 3 sections. The first sections contains primary information like peptide activity, source, sequence, etc. In the secondary information section user can access the tertiary structure as well as the physico-chemical properties by clicking the respective links. Further there is also link of the source database and research article from which the peptide data is retrieved. Download the information by clicking
| Primary Information |
|---|
| PPepDB ID | PPepDB_3948 |
| Peptide Name | Viscotoxin-A3 (VtA3) |
| PMID(s) | 10947973, 5719166, 4941626, 1710983, 15086811 |
| Plant Source (Scientific Name) | Viscum album |
| Plant Source (Common Name) | European mistletoe |
| Plant Family | Santalaceae |
| Peptide Family | Thionin |
| Peptide Function | Antifungal |
| Peptide Function Description | To control and/or inhibit the growth of phytopathogenic fungi. |
| Activity Against | Fungi: Fusarium solani, Sclerotinia sclerotiorum, Phytophtora infestans. |
| IC50 value | --NA-- |
| Sequence | KSCCPNTTGRNIYNACRLTGAPRPTCAKLSGCKIISGSTCPSDYPK |
| Sequence Length | 46 |
| Validation | Experimental evidence at protein level |
| Average Molecular Weight (Da) | 4835.6 |
| Monoisotopic Molecular Weight (Da) | 4832.31 |
| Isoelectric Point (pI) | 9.3 |
| Method / Extraction | NMR, HPLC |
| External links (Uniprot, PDB and Source Information Database) |
|---|
| Uniprot | P01538 |
| NCBI | --NA-- |
| EMBL | --NA-- |
| Link to Source Databases | PhytAMP_PHYT00096, APD_01277 |
|---|
| Addtional Information | Mistletoe extracts have immunomodulatory activity by increasing natural killer (NK) cell-mediated killing of tumor cells but spare nontarget cells from NK lysis (Tabiasco et al., 2002). It consists of 3 S-S bonds. The arrangement of the cysteine pairing was determined as Cys3-Cys40, Cys4-Cys32 and Cys16-Cys26. In addition to the NMR structure (link), a crystal structure has also been solved with the same fold (Acta Cryst 2003; D59: 2125-32). You can rotate, zoom, and view the 3D structure here in the PDB. Another six homologs Vt A1, A2, B, C1, 1-PS, and U-PS have been found to date (see subsequent entries). VtA3 is the most cytotoxic while VtB is the least toxic. MOA: antifungi by membrane targeting and forming channels. Updated 2/2014; 8/2015. |
