Detailed Peptide Information
This page shows detailed information of individual peptides present in PlantPepDB database. The page is majorly divided into 3 sections. The first sections contains primary information like peptide activity, source, sequence, etc. In the secondary information section user can access the tertiary structure as well as the physico-chemical properties by clicking the respective links. Further there is also link of the source database and research article from which the peptide data is retrieved. Download the information by clicking
| Primary Information |
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| PPepDB ID | PPepDB_3810 |
| Peptide Name | Varv-F |
| PMID(s) | 20580652, 25815333, 10075760, 12477048 |
| Plant Source (Scientific Name) | Viola arvensis, Viola tricolor |
| Plant Source (Common Name) | European field pansy, heartsease |
| Plant Family | Violaceae |
| Peptide Family | Cyclic Peptide |
| Peptide Function | Cytotoxic, Anticancer, Enzymatic-degradation, Antimicrobial |
| Peptide Function Description | participates in a plant defense mechanism.; Shows significant cytotoxic activity; Resist enzymatic degradation in biological fluids. |
| Activity Against | Human Myeloma cells RPMI-8226/s (IC50: 5.90 µM),Human Myeloma cells RPMI-8226/Dox40 (IC50: 3.14 µM),Human Myeloma cells RPMI-8226/LR-5 (IC50: 6.31 µM),Human histiocytic lymphoma U-937/GTB (IC50: 7.07 µM),Human histiocytic lymphoma U-937-Vcr (IC50: 7.45 µM),Human renal adenocarcinoma ACHN (IC50: 2.63 µM),Human lymphoblastic leukemia CCRF-CEM (IC50: 7.13 µM),Human lymphoblastic leukemia CCRF-CEM/VM-1 (IC50: 7.15 µM),Human lung carcinoma NCI-H69 (IC50: 7.49 µM),Human lung carcinoma NCI-H69AR (IC50: 7.12 µM),Human glioblastoma U251-MG (IC50: 44.49 µg/ml),Human breast adenocarcinoma MDA-MB-231 (IC50: >10 µg/ml),Human lung carcinoma A549 (IC50: >10 µg/ml),Human prostate cancer DU145 (IC50: >10 µg/ml),Human hepatocarcinoma BEL-7402 (IC50: >10 µg/ml) |
| IC50 value | 5.90 µM | 3.14 µM | 6.31 µM | 7.07 µM | 7.45 µM | 2.63 µM | 7.13 µM | 7.15 µM | 7.49 µM | 7.12 µM | 44.49 µg/ml | >10 µg/ml | >10 µg/ml | >10 µg/ml | >10 µg/ml |
| Sequence | GVPICGETCTLGTCYTAGCSCSWPVCTRN |
| Sequence Length | 29 |
| Validation | Experimental evidence at protein level |
| Average Molecular Weight (Da) | 2983.43 |
| Monoisotopic Molecular Weight (Da) | 2981.23 |
| Isoelectric Point (pI) | 5.96 |
| Method / Extraction | HPLC, NMR |
| External links (Uniprot, PDB and Source Information Database) |
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| Uniprot | P58451 |
| NCBI | --NA-- |
| EMBL | --NA-- |
| Link to Source Databases | DBAASP_1771, PhytAMP_PHYT00215, EROP-Moscow_14288, EROP-Moscow_04045, Cybase_64, APD_01031 |
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| Addtional Information | The structures of this peptide in the crystal, in solution (NMR?ray), and in complex with DPC are nearly identical, indicating structural rigidity and good for engineering (J Biol Chem. 2009 Apr 17;284(16):10672-83). You can rotate, zoom, and view the 3D structure here in the PDB . Updated 2/2014. |
