Detailed Peptide Information

This page shows detailed information of individual peptides present in PlantPepDB database. The page is majorly divided into 3 sections. The first sections contains primary information like peptide activity, source, sequence, etc. In the secondary information section user can access the tertiary structure as well as the physico-chemical properties by clicking the respective links. Further there is also link of the source database and research article from which the peptide data is retrieved. Download the information by clicking

Primary Information
PPepDB ID	PPepDB_2213
Peptide Name	Varv peptide E (Cycloviolacin-O12)
PMID(s)	20580652, 14987049, 10075760, 18618891, 18081258
Plant Source (Scientific Name)	Viola tricolor, Viola arvensis, Viola baoshanensis, Viola yedoensis, Viola tianshanica, Viola abyssinica, Viola philippica
Plant Source (Common Name)	heartsease, European field pansy, Violet, Chinese Voilet
Plant Family	Violaceae
Peptide Family	Cyclotide
Peptide Function	Antiviral, Anticancer, Nematocide, Anti-HIV
Peptide Function Description	participates in a plant defense mechanism, Target site: lipid bilayer; shows 50% Hemolysis against Human erythrocytes at 6.96 µM
Activity Against	Human glioblastoma U251-MG (IC50: 38.84 µg/ml), Human breast adenocarcinoma MDA-MB-231 (IC50: >10 µg/ml), Human lung carcinoma A549 (IC50: >10 µg/ml), Human prostate cancer DU145 (IC50: >10 µg/ml), Human hepatocarcinoma BEL-7402 (IC50: >10 µg/ml), Human histiocytic lymphoma U-937/GTB (IC50: 4 µM), Human Myeloma cells RPMI-8226/s (IC50: 4 µM)
IC50 value	38.84 µg/ml | >10 µg/ml | >10 µg/ml | >10 µg/ml | >10 µg/ml | 4 µM | 4 µM
Sequence	GLPICGETCVGGTCNTPGCSCSWPVCTRN
Sequence Length	29
Validation	Experimental evidence at protein level
Average Molecular Weight (Da)	2916.34
Monoisotopic Molecular Weight (Da)	2914.2
Isoelectric Point (pI)	5.96
Method / Extraction	Amino acid analysis, MS

Secondary Information
Tertiary Structure and DSSP Report	Click to View Structure
Physico-Chemical Properties of peptides	Click to View Physico-Chemical Details of PPepDB_2213

External links (Uniprot, PDB and Source Information Database)
Uniprot	P83836, P83835, B5B3Z6, B5B3Z5, A5YRZ4, A5YRZ3
NCBI	46577590
EMBL	--NA--
Link to Source Databases	DBAASP_2451, PhytAMP_PHYT00214, EROP-Moscow_04044, Cybase_38, CAMPSQ6434, APD_01030
Addtional Information	Synthesis Type : Ribosomal, This peptide found in Viola arvensis is also recorded in the UniProtKB entry P83835, The Kalata S showed significant activity in inhibiting development of nematode larvae and motility of adult worms; Shows potential anti-HIV activity; Shown to possess cytotoxic activity in cancer cells.