Detailed Peptide Information
This page shows detailed information of individual peptides present in PlantPepDB database. The page is majorly divided into 3 sections. The first sections contains primary information like peptide activity, source, sequence, etc. In the secondary information section user can access the tertiary structure as well as the physico-chemical properties by clicking the respective links. Further there is also link of the source database and research article from which the peptide data is retrieved. Download the information by clicking
| Primary Information |
|---|
| PPepDB ID | PPepDB_2125 |
| Peptide Name | Cyclotide chassatide C7, Uncyclotide ChaC7 |
| PMID(s) | 22467870 |
| Plant Source (Scientific Name) | Chassalia chartacea |
| Plant Source (Common Name) | --NA-- |
| Plant Family | Rubiaceae |
| Peptide Family | Cyclotide |
| Peptide Function | Antibacterial, Anticancer, Cytotoxic, Hemolytic |
| Peptide Function Description | Target site: lipid bilayer; shows 50% Hemolysis against Human erythrocytes at 11.6 µM ; Shown to possess antimicrobial, cytotoxic, and hemolytic activities and the oxidation of two Met residue causes loss of bioactivities, strengthening the importance of the hydrophobic patch for membrane interaction. |
| Activity Against | Escherichia coli (MIC: 6.4 µM), Staphylococcus aureus (MIC: >80 µM), Staphylococcus epidermidis (MIC: >80 µM), Human cervical carcinoma HeLa (IC50: 1.2 µM) |
| IC50 value | 1.2 µM |
| Sequence | IPCGESCVWIPCITAIAGCSCKNKVCYT |
| Sequence Length | 28 |
| Validation | Experimental evidence at protein level |
| Average Molecular Weight (Da) | 2963.57 |
| Monoisotopic Molecular Weight (Da) | 2961.34 |
| Isoelectric Point (pI) | 7.77 |
| Method / Extraction | PcR, MS |
| External links (Uniprot, PDB and Source Information Database) |
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| Uniprot | I0B6F4 |
| NCBI | --NA-- |
| EMBL | --NA-- |
| Link to Source Databases | DBAASP_4286, Cybase_866, CAMPSQ3676, APD_01989 |
|---|
| Addtional Information | Synthesis Type : Ribosomal; The compound, however, is also quite toxic (50% hemolysis of human type A blood cells: HL50 11.6 uM). TOXIC TO HeLa cells (IC50 1.2 uM). This is an acyclic peptide. Compared to cyclotides, the C-terminal D/N critical for cyclization is lacking. Surprisingly, this linear form is not only more abundant but also more active than the circular peptides identified in the same plant. APD updated 4/2015. |
