Detailed Peptide Information
This page shows detailed information of individual peptides present in PlantPepDB database. The page is majorly divided into 3 sections. The first sections contains primary information like peptide activity, source, sequence, etc. In the secondary information section user can access the tertiary structure as well as the physico-chemical properties by clicking the respective links. Further there is also link of the source database and research article from which the peptide data is retrieved. Download the information by clicking
| Primary Information |
|---|
| PPepDB ID | PPepDB_2101 |
| Peptide Name | Sesquin |
| PMID(s) | 15949629 |
| Plant Source (Scientific Name) | Vigna unguiculata subsp.sesquipedalis |
| Plant Source (Common Name) | cowpea |
| Plant Family | Fabaceae |
| Peptide Family | Defensin |
| Peptide Function | Antibacterial, Antifungal, Antiviral, Anti-HIV, Anticancer |
| Peptide Function Description | Target site: lipid bilayer ; It shows antifungal and antibacterial activity and inhibit the growth of bacteria. It also exerted antiproliferative activity toward breast cancer (MCF-7) cells and leukemia M1 cells. It also exhibit some inhibitory activity toward human immunodeficiency virus-type 1 reverse transcriptase. |
| Activity Against | Botrytis cinerea(IC50: 2.5 ±0.01 µM), Botrytis cinerea(IC50: 9.54 ±0.11 µM), Botrytis cinerea(IC50: 8.68 ±0.01 µM), Fusarium oxysporum(IC50: 1.4 ±0.02 µM), Fusarium oxysporum (IC50: 8.1 ±0.07 µM), Fusarium oxysporum(IC50: 7.7 ±0.06 µM ), Mycosphaerella arachidicola(IC50: 0.15 ±0.002 µM), Mycosphaerella arachidicola(IC50: 0.54 ±0.04 µM), Mycosphaerella arachidicola(IC50: 0.84 ±0.02 µM), Proteus vulgaris(IC50: 75 ±6 µM), Mycobacterium phlei (IC50: 87 ±5 µM), Bacillus megaterium(IC50: 105 ±5 µM), Bacillus subtilis(IC50: 98 ±2 µM), Proteus vulgaris, Mycobacterium phlei, Bacillus megaterium, Bacillus subtilis |
| IC50 value | 2.5 ±0.01 µM | 9.54 ±0.11 µM | 8.68 ±0.01 µM | 1.4 ±0.02 µM | 8.1 ±0.07 µM | 7.7 ±0.06 µM | 0.15 ±0.002 µM | 0.54 ±0.04 µM | 0.84 ±0.02 µM | 75 ±6 µM | 87 ±5 µM | 105 ±5 µM | 98 ±2 µM |
| Sequence | KTCENLADTY |
| Sequence Length | 10 |
| Validation | Experimental evidence at protein level |
| Average Molecular Weight (Da) | 1157.26 |
| Monoisotopic Molecular Weight (Da) | 1156.51 |
| Isoelectric Point (pI) | 4.37 |
| Method / Extraction | Affi-gel blue gel, Mono S and Superdex 75 columns |
| External links (Uniprot, PDB and Source Information Database) |
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| Uniprot | P84868 |
| NCBI | 109894868 |
| EMBL | --NA-- |
| Link to Source Databases | DBAASP_500, CAMPSQ7, APD_00553 |
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| Addtional Information | Synthesis Type : Ribosomal; Exerted antiproliferative activity toward breast cancer (MCF-7) cells and leukemia M1 cells , Sesquin also inhibits HIV-1 reverse transcriptase; Warning: Only the N-terminal sequence of this 7 kDa peptide is available. Active against fungi B. cinerea, F.oxysporum, and M. arachidicola. Inhibit leukemia cells M1 abd breast cancer cells MCF-7. HIV (50 uM inhibit 35%). MOA: see reference title. Updated 12/2017. |
