Detailed Peptide Information
This page shows detailed information of individual peptides present in PlantPepDB database. The page is majorly divided into 3 sections. The first sections contains primary information like peptide activity, source, sequence, etc. In the secondary information section user can access the tertiary structure as well as the physico-chemical properties by clicking the respective links. Further there is also link of the source database and research article from which the peptide data is retrieved. Download the information by clicking
| Primary Information |
|---|
| PPepDB ID | PPepDB_1924 |
| Peptide Name | Psysol 2 |
| PMID(s) | 25894999 |
| Plant Source (Scientific Name) | Psychotria solitudinum |
| Plant Source (Common Name) | --NA-- |
| Plant Family | Rubiaceae |
| Peptide Family | Cyclotide |
| Peptide Function | Enzymatic-degradation, Enzyme-inhibitor |
| Peptide Function Description | Shown to possess proteolytic activity of trypsin or chymotrypsin (IC50=25 µM) |
| Activity Against | --NA-- |
| IC50 value | --NA-- |
| Sequence | GLPICGESCVGGTCNTPGCTCTWPVCTRN |
| Sequence Length | 29 |
| Validation | Experimental evidence at protein level |
| Average Molecular Weight (Da) | 2930.37 |
| Monoisotopic Molecular Weight (Da) | 2928.22 |
| Isoelectric Point (pI) | 5.96 |
| Method / Extraction | MS |
| External links (Uniprot, PDB and Source Information Database) |
|---|
| Uniprot | --NA-- |
| NCBI | --NA-- |
| EMBL | --NA-- |
| Link to Source Databases | Cybase_1151, APD_02658 |
|---|
| Addtional Information | APD analysis reveals that the sequence of this peptide most resembles (93.1% similarity) Cycloviolacin O22. Mol. Wt: 2912.4; GRAVY=0.16. It inhibits Human Prolyl Oligopeptidase Activity (IC50 of 25 uM), a target for the cognitive deficits associated with several psychiatric and neurodegenerative diseases, such as schizophrenia and Parkinson's disease. cf. kalata B1 inhibited POP activity with an IC50 of 5.6 uM. |
