Detailed Peptide Information
This page shows detailed information of individual peptides present in PlantPepDB database. The page is majorly divided into 3 sections. The first sections contains primary information like peptide activity, source, sequence, etc. In the secondary information section user can access the tertiary structure as well as the physico-chemical properties by clicking the respective links. Further there is also link of the source database and research article from which the peptide data is retrieved. Download the information by clicking
| Primary Information |
|---|
| PPepDB ID | PPepDB_1552 |
| Peptide Name | TPP3 |
| PMID(s) | 22442231 |
| Plant Source (Scientific Name) | Solanum lycopersicum |
| Plant Source (Common Name) | Tomato |
| Plant Family | Solanaceae |
| Peptide Family | Defensin |
| Peptide Function | Antimicrobial, Antifungal, Anticancer |
| Peptide Function Description | --NA-- |
| Activity Against | --NA-- |
| IC50 value | --NA-- |
| Sequence | QICKAPSQTFPGLCFMDSSCRKYCIKEKFTGGHCSKLQRKCLCTKPC |
| Sequence Length | 47 |
| Validation | Experimental evidence at protein level |
| Average Molecular Weight (Da) | 5305.36 |
| Monoisotopic Molecular Weight (Da) | 5301.52 |
| Isoelectric Point (pI) | 9.2 |
| Method / Extraction | X-ray |
| External links (Uniprot, PDB and Source Information Database) |
|---|
| Uniprot | --NA-- |
| NCBI | --NA-- |
| EMBL | --NA-- |
| Link to Source Databases | CAMPSQ2976, APD_00984 |
|---|
| Addtional Information | MOA: TPP3 interacts with plasma membrane phosphatidylinositol(4,5)-bisphosphate (PIP2) to mediate membrane permeabilization. TPP3 forms an oligomer with PIP2 (or PI(4,5)P2) in vitro and has been crystallized. It can also toxic to cancer cells U937 and induces plasma membrane blebs (Baxter AA et al., 2015). You can rotate, zoom, and view the 3D structure here in the PDB . Updated 3/2015. | K6, K42 |
