Detailed Peptide Information
This page shows detailed information of individual peptides present in PlantPepDB database. The page is majorly divided into 3 sections. The first sections contains primary information like peptide activity, source, sequence, etc. In the secondary information section user can access the tertiary structure as well as the physico-chemical properties by clicking the respective links. Further there is also link of the source database and research article from which the peptide data is retrieved. Download the information by clicking
| Primary Information |
|---|
| PPepDB ID | PPepDB_5242 |
| Peptide Name | RIP3_MOMCH |
| PMID(s) | --NA-- |
| Plant Source (Scientific Name) | Momordica charantia |
| Plant Source (Common Name) | Bitter melon |
| Plant Family | Cucurbitaceae |
| Peptide Family | --NA-- |
| Peptide Function | Signaling-peptide |
| Peptide Function Description | 3D-structure; Antiviral protein; Direct protein sequencing; Glycoprotein; Hydrolase; Plant defense; Protein synthesis inhibitor; Signal; Toxin | Ribosome-inactivating protein beta-momorcharin precursor (EC 3.2.2.22),(rRNA N-glycosidase) (MAP 30) (B-MMC). |
| Activity Against | --NA-- |
| IC50 value | --NA-- |
| Sequence | DVSYFFKESPPEAYNILFKGTRKITLPYTGNYENLQTAAHKIRENIDLGLKPNLAIISLENQWSALSKQIFLAQNQGGKFRNPVDLIKPTGERFQVTNVDMVKCLLLSFLIIAIFIGVPTAKGDVNFDLSTATAKTYTKFIEDFRATLPFPALSSAITTLFYYNAQSAPSALLVLIQTTAEAARFKYIERHVAKYVATNFSDVVKGNIKLLLNSRASTADENFITTMTLLGESVVNSHKVYDIPLLYSTISDSRRFILLNLTSYAYETISVAIDVTNVYVVAYRTR |
| Sequence Length | 286 |
| Validation | Experimental evidence at protein level |
| Average Molecular Weight (Da) | 32030.88 |
| Monoisotopic Molecular Weight (Da) | 32010.95 |
| Isoelectric Point (pI) | 9.08 |
| Method / Extraction | --NA-- |
| External links (Uniprot, PDB and Source Information Database) |
|---|
| Uniprot | P24817 |
| NCBI | --NA-- |
| EMBL | S79450 |
| Link to Source Databases | SPdb221296 |
|---|
| Addtional Information | FUNCTION:Irreversibly relaxes supercoiled DNA and catalyzes double-stranded breakage. Acts also as a ribosome inactivating protein.CATALYTIC ACTIVITY:Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.PTM:Bound to a branched hexasaccharide.MISCELLANEOUS:Possesses anti-HIV and antitumoral activities.Inhibits HIV-1 integrase.MISCELLANEOUS:Manganese or zinc required for enhancing substrate binding rather than catalysis.MISCELLANEOUS:The oligosaccharide does not influence the fold of the polypeptide chain and probably does not play a role in the enzymatic function.MISCELLANEOUS:Is not toxic to uninfected normal cells as it cannot enter into them.SIMILARITY:Belongs to the ribosome-inactivating protein family.Type 1 RIP subfamily. |
