Detailed Peptide Information
This page shows detailed information of individual peptides present in PlantPepDB database. The page is majorly divided into 3 sections. The first sections contains primary information like peptide activity, source, sequence, etc. In the secondary information section user can access the tertiary structure as well as the physico-chemical properties by clicking the respective links. Further there is also link of the source database and research article from which the peptide data is retrieved. Download the information by clicking
| Primary Information |
|---|
| PPepDB ID | PPepDB_4928 |
| Peptide Name | BRI1_ARATH |
| PMID(s) | --NA-- |
| Plant Source (Scientific Name) | Arabidopsis thaliana |
| Plant Source (Common Name) | Mouse-ear cress |
| Plant Family | Brassicaceae |
| Peptide Family | --NA-- |
| Peptide Function | Signaling-peptide |
| Peptide Function Description | ATP-binding; Complete proteome; Endosome; Glycoprotein; Kinase; Leucine-rich repeat; Lipid-binding; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Repeat; Serine/threonine-protein kinase; Signal; Steroid-binding; Transferase; Transmembrane | Protein BRASSINOSTEROID INSENSITIVE 1 precursor (EC 2.7.11.1) (AtBRI1),(Brassinosteroid LRR receptor kinase).Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pa |
| Activity Against | --NA-- |
| IC50 value | --NA-- |
| Sequence | CSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPDISGNKLSGDFSRAISTCTELKLLNISSNQFVGPIPPLPLKSLQYLSLAEDNNGSMMFLDMSYNMLSGYIPKEIGSMPYLFILNLGHNDISGSIPDEVGDELKHLAISGNKISGDVDVSRCVNLEFLDVSSNNFSTGIPFLGDCSALQHLERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNFPPAKFLNNPGLCGYPLPRCDPSNADGYAHHQRSHGRRPASLAGSVAMGLGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVILKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPLLGYCKVGDKFLNVSSNTLDFPGKVSGGLKLNSLEVLDLSANSISGANVVGWVLSDGCGKNDGMKKECHGAGNLLEFQGIRSEQLNRLSTRNPCNITSRVYGGHTSPTFKQHAKLRISDVFDPELMKEDPALEIELLQHLKVAVACLDDRAWRRPTMVQLESLFLSNSHINGSVSGFKCSASLTSLDLSRNSLSGPVTTLTSLGSCSGLLFSFVCIFGLILVGREMRKRRRKKEAELEMYAEGHGNSGDRTANNTNWKLLLPDWSSNKNPCTFDGVTCRDDKVTSIDLSSKPLNVGFSAVSSSLLSLTGLRGLNILDLSSNKLDGRIPQAMSALTMLTEIDLSNNNLSGPIPEMGQFETMKTFSSFFLSVTTLFFFSFFSLSFQASPSQSLYREIHQLISFKDVLPDKNNFSGELPMDTLLKMRGLKVLDLSFNEFSGELPESLTNLSASLLTLDLSSNNFSGPILPNLCQNPKNTLQELYLQNNGFTGKIPPTLSNCSELVSLHLSFNNIPAELGDCRSLIWLDLNTNLFNGTIPAAMFKQSGKIAANFIAGKRYVYINKFTGEIPDFLSGACDTLTGLDLSGNHFYGAVPPFFGSCSLLESLALSSNTGEIPSGLSNCTNLNWISLSNNRLTGEIPKWIGRLENLAILKLSNNSFSGTGVKEALSINLAAFEKPLRKLTFADLLQATNGFHNDSLIGSGGFGDVYKAVMAMFKEIQAGSGIDSQSTIRSIEDGGFSTIEMVDMSIKEVPEGKLYLSGTIPSSLGSLSKLRDLKLWLNMLEGEIPQELMYVKTLETLILDFNDL |
| Sequence Length | 1196 |
| Validation | Experimental evidence at protein level |
| Average Molecular Weight (Da) | 130543.17 |
| Monoisotopic Molecular Weight (Da) | 130460.07 |
| Isoelectric Point (pI) | 6 |
| Method / Extraction | --NA-- |
| External links (Uniprot, PDB and Source Information Database) |
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| Uniprot | O22476 |
| NCBI | --NA-- |
| EMBL | AF017056 |
| Link to Source Databases | SPdb26320 |
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| Addtional Information | FUNCTION:Receptor with a serine/threonine-protein kinase activity. Regulates, in response to brassinosteroid binding, a signaling cascade involved in plant development, including expression of light- and stress-regulated genes, promotion of cell elongation, normal leaf and chloroplast senescence, and flowering.Binds brassinolide, and less effectively castasterone, but not 2,3,22,23-O-tetramethylbrassinolide or ecdysone. May be involved in a feedback regulation of brassinosteroid biosynthesis.Phosphorylates BRI1-associated receptor kinase 1 (BAK1) and Transthyretin-Like protein (TTL) in vitro.CATALYTIC ACTIVITY:ATP a protein = ADP a phosphoprotein.ENZYME REGULATION:Activated by Ser and Thr phosphorylation.SUBUNIT:Homodimer in the plasma membrane (Probable). Heterodimer with BAK1 in the endosomes. Interacts with TTL in a kinase- dependent manner.TISSUE SPECIFICITY:Expressed ubiquitously.DEVELOPMENTAL STAGE:Expressed constitutively in either dark- or light-grown seedlings.DOMAIN:Contains one leucine-zipper motif and two pairs of conservatively spaced Cys (Cys pair 1 and 2) involved in forming heterodimers.DOMAIN:A 70 amino acid island between the 20th and the 21th LRR is essential for the binding of brassinosteroids.PTM:Phosphorylated on at least 12 sites, with a preference for Ser residues.MISCELLANEOUS:Binding of brassinosteroid induces intramolecular autophosphorylation of BRI1. Interaction with BAK1 activates both receptor kinases and the full activation of either receptor kinase requires transphosphorylation by their partners. Optimum in vitro phosphorylation of the substrate requires Arg or Lys residues at P-3, P-4, and P-5 (relative to the phosphorylated amino acid at P=0).SIMILARITY:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.SIMILARITY:Contains 25 LRR (leucine-rich) repeats.SIMILARITY:Contains 1 protein kinase domain. |
