Detailed Peptide Information
This page shows detailed information of individual peptides present in PlantPepDB database. The page is majorly divided into 3 sections. The first sections contains primary information like peptide activity, source, sequence, etc. In the secondary information section user can access the tertiary structure as well as the physico-chemical properties by clicking the respective links. Further there is also link of the source database and research article from which the peptide data is retrieved. Download the information by clicking
| Primary Information |
|---|
| PPepDB ID | PPepDB_3954 |
| Peptide Name | PN-AMP1 |
| PMID(s) | 9507071 |
| Plant Source (Scientific Name) | Ipomoea nil, Pharbitis nil |
| Plant Source (Common Name) | Japanese morning glory |
| Plant Family | Convolvulaceae |
| Peptide Family | Hevein |
| Peptide Function | Antibacterial, Antifungal, Antiyeast |
| Peptide Function Description | --NA-- |
| Activity Against | Bacteria: Gram-positive Bacillus subtilis (IC50=38 µg/mL). No effect on Gram-negative bacteria. Fungi: Medium A / Medium A (IC50 µg/mL) Botrytis cinerea (16, 150), Colletotrichum langenarium (10, >200), Sclerotinia sclerotiorum (11, >200), Fusarium oxysporum (10, >200), Rhizoctonia solani (26, >200), Phytophthora capsici (5, 130), Phytophthora parasitica (3, 90), Pythium spp. (ND, ND). Yeast: Saccharomyces cerevisiae (IC50= 14 µg/mL; >200 µg/mL) NOTE! Medium A = Medium A supplemented with 5mM CaCl2. |
| IC50 value | 38 µg/mL | 16 µg/mL | 150 µg/mL | 10 µg/mL | >200 µg/mL | 11 µg/mL | >200 µg/mL | 10 µg/mL | >200 µg/mL | 26 µg/mL | >200 µg/mL | 5 µg/mL | 130 µg/mL | 3 µg/mL | 90 µg/mL | 14 µg/mL | >200 µg/mL |
| Sequence | QQCGRQASGRLCGNRLCCSQWGYCGSTASYCGAGCQSQCRS |
| Sequence Length | 41 |
| Validation | Experimental evidence at protein level |
| Average Molecular Weight (Da) | 4325.82 |
| Monoisotopic Molecular Weight (Da) | 4322.76 |
| Isoelectric Point (pI) | 8.76 |
| Method / Extraction | X-ray |
| External links (Uniprot, PDB and Source Information Database) |
|---|
| Uniprot | P81591 |
| NCBI | 5902771 |
| EMBL | --NA-- |
| Link to Source Databases | PhytAMP_PHYT00233, CAMPSQ542, APD_00270 |
|---|
| Addtional Information | Compared to Pn-AMP2 (APD entry 1052), Pn-AMP1 contains one additional residue (Ser) at the C-terminus. Rich in G; contains four disulfide bonds.Active against fungi even if they do not contain chitin. It most likely perturbs the membranes. Transgenic plants: expression of this peptide in tobacco improves resistance to pathogens (Montesinos E 2007 FEMS Microbiol Lett 270, 1-11). |
