Detailed Peptide Information
This page shows detailed information of individual peptides present in PlantPepDB database. The page is majorly divided into 3 sections. The first sections contains primary information like peptide activity, source, sequence, etc. In the secondary information section user can access the tertiary structure as well as the physico-chemical properties by clicking the respective links. Further there is also link of the source database and research article from which the peptide data is retrieved. Download the information by clicking
| Primary Information |
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| PPepDB ID | PPepDB_3859 |
| Peptide Name | Varv-A |
| PMID(s) | 15328347, 16872274, 20580652, 26399495, 18618891, 18081258, 12477048, 14987049, 18191970, 9548831 |
| Plant Source (Scientific Name) | Viola arvensis, Viola hederacea, Viola biflora, Viola odorata, Viola tricolor |
| Plant Source (Common Name) | European field pansy, Native Violet, alpine yellow-violet, Sweet violet, heartsease |
| Plant Family | Violaceae |
| Peptide Family | Cyclic Peptide |
| Peptide Function | Cytotoxic, Nematocide, Hemolytic, Anti-HIV, Anticancer, Antimicrobial |
| Peptide Function Description | Shows significant cytotoxic activity, The Kalata S showed significant activity in inhibiting development of nematode larvae and motility of adult worms; Shows potential anti-HIV activity; Exhibited strong cytotoxic activities, which varied in a dose-dependent manner; Shown to possess cytotoxic activity in cancer cells. |
| Activity Against | U251 cell line(IC50=37.18g/mL), Haemonchus contortus and Trichostrongylus colubriformis |
| IC50 value | 37.18 µg/mL |
| Sequence | GLPVCGETCVGGTCNTPGCSCSWPVCTRN |
| Sequence Length | 29 |
| Validation | Experimental evidence at protein level |
| Average Molecular Weight (Da) | 2902.32 |
| Monoisotopic Molecular Weight (Da) | 2900.18 |
| Isoelectric Point (pI) | 5.96 |
| Method / Extraction | HPLC |
| External links (Uniprot, PDB and Source Information Database) |
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| Uniprot | Q5USN7, P58446, P58458 |
| NCBI | 190411620, 17433131 |
| EMBL | --NA-- |
| Link to Source Databases | PhytAMP_PHYT00210, EROP-Moscow_14276, EROP-Moscow_04040, Cybase_37, CAMPSQ6442, CAMPSQ6419, APD_01026 |
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| Addtional Information | Varv A and Kalata S have identical AA sequence. This peptide has been identified in six plant species, Kalata S can be extracted from plant material by microwave-assisted extraction, less efficient than maceration, as described in GenBank with the id 17433131 and in UnirotKB/SwissProt with id P58446 and P85525. |
