Detailed Peptide Information
This page shows detailed information of individual peptides present in PlantPepDB database. The page is majorly divided into 3 sections. The first sections contains primary information like peptide activity, source, sequence, etc. In the secondary information section user can access the tertiary structure as well as the physico-chemical properties by clicking the respective links. Further there is also link of the source database and research article from which the peptide data is retrieved. Download the information by clicking
| Primary Information |
|---|
| PPepDB ID | PPepDB_3804 |
| Peptide Name | Lunatusin |
| PMID(s) | 16269344 |
| Plant Source (Scientific Name) | Phaseolus lunatus |
| Plant Source (Common Name) | Lima bean |
| Plant Family | Fabaceae |
| Peptide Family | Defensin |
| Peptide Function | Antibacterial, Antifungal, Antiviral, Anticancer, Anti-HIV |
| Peptide Function Description | Inhibited proliferation in the breast cancer cell line MCF-7. It reduced the activity of HIV-1 reverse transcriptase and it also inhibit the translation in a cell-free rabbit reticulocyte lysate system. Its anti-fungal activity was retained after incubation with trypsin. |
| Activity Against | F. oxysporum (IC50=1.9 µM), B. Cinerea (IC50=2.6 µM), M. arachidicola(IC50=0.32 µM), Mycobacterium phlei(IC50=96 ± 9 µM), Proteus vulgaris(IC50=81 ± 6 µM), Breast cancer cells(IC50=5.71 µM), HIV-1 reverse transcriptase(IC50=120 µM) |
| IC50 value | 1.9 µM | 2.6 µM | 0.32 µM | 96 ± 9 µM | 81 ± 6 µM | 5.71 µM | 120 µM |
| Sequence | KTCENLADTFRGPCFATSNC |
| Sequence Length | 20 |
| Validation | Experimental evidence at protein level |
| Average Molecular Weight (Da) | 2178.44 |
| Monoisotopic Molecular Weight (Da) | 2176.93 |
| Isoelectric Point (pI) | 6.05 |
| Method / Extraction | Affinity chromatography and gel filtration |
| External links (Uniprot, PDB and Source Information Database) |
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| Uniprot | --NA-- |
| NCBI | --NA-- |
| EMBL | --NA-- |
| Link to Source Databases | CAMPSQ2794, APD_00532 |
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| Addtional Information | Trypsin-stable antimicrobial peptide; Warning: Only the sequence for the N-terminal 20 residues is provided. MOA: This 7 kDa isolate can reduce the activity of HIV-1 reverse transcriptase. |
