Detailed Peptide Information
This page shows detailed information of individual peptides present in PlantPepDB database. The page is majorly divided into 3 sections. The first sections contains primary information like peptide activity, source, sequence, etc. In the secondary information section user can access the tertiary structure as well as the physico-chemical properties by clicking the respective links. Further there is also link of the source database and research article from which the peptide data is retrieved. Download the information by clicking
| Primary Information |
|---|
| PPepDB ID | PPepDB_263 |
| Peptide Name | Viscotoxin A1 |
| PMID(s) | --NA-- |
| Plant Source (Scientific Name) | Viscum album |
| Plant Source (Common Name) | European mistletoe |
| Plant Family | Santalaceae |
| Peptide Family | Thionin |
| Peptide Function | Anticancer |
| Peptide Function Description | --NA-- |
| Activity Against | --NA-- |
| IC50 value | --NA-- |
| Sequence | KSCCPNTTGRNIYNTCRLTGSSRETCAKLSGCKIISASTCPSNYPK |
| Sequence Length | 46 |
| Validation | Experimental evidence at protein level |
| Average Molecular Weight (Da) | 4916.63 |
| Monoisotopic Molecular Weight (Da) | 4913.32 |
| Isoelectric Point (pI) | 9.3 |
| Method / Extraction | X-ray |
| External links (Uniprot, PDB and Source Information Database) |
|---|
| Uniprot | --NA-- |
| NCBI | --NA-- |
| EMBL | --NA-- |
| Link to Source Databases | APD_01279 |
|---|
| Addtional Information | Extracts from Viscum album L. are widely used as an adjuvant in complementary cancer therapy. Treatment of lymphocytes with VT for 2 hours resulted in the binding of Annexin-V, permeabilisation of cell membranes, and generation of ROI (Bussing A et al., 1998). Mistletoe extracts have immunomodulatory activity by increasing natural killer (NK) cell-mediated killing of tumor cells but spare nontarget cells from NK lysis (Tabiasco et al., 2002). The arrangement of the cysteine pairing was determined as Cys3-Cys40, Cys4-Cys32 and Cys16-Cys26. The 3D structure of this peptide has been determined to high resolution (1.25 A) by X-ray crystallography (Pal A et al., 2008). You can rotate, zoom, and view the 3D structure here in the PDB. Updated 6/2017. |
