Detailed Peptide Information
This page shows detailed information of individual peptides present in PlantPepDB database. The page is majorly divided into 3 sections. The first sections contains primary information like peptide activity, source, sequence, etc. In the secondary information section user can access the tertiary structure as well as the physico-chemical properties by clicking the respective links. Further there is also link of the source database and research article from which the peptide data is retrieved. Download the information by clicking
| Primary Information |
|---|
| PPepDB ID | PPepDB_2205 |
| Peptide Name | Ib-AMP4 |
| PMID(s) | 3713064, 23713064, 9305910, 9454588 |
| Plant Source (Scientific Name) | Impatiens balsamina |
| Plant Source (Common Name) | Garden balsam |
| Plant Family | Balsaminaceae |
| Peptide Family | Impatiens family |
| Peptide Function | Antibacterial, Hemolytic, Cytotoxic, Antifungal |
| Peptide Function Description | plays a role in the defense of the germinating seed agasnst microorganisms by inhibiting the growth of a range of filamentous fungi and bacteria, especially Gram-positive bacteria, Target site: lipid bilayer; Not active up to 100 µg/ml against Sheep erythrocytes; shows 15% Hemolysis against Sheep erythrocytes at 200 µg/ml |
| Activity Against | Acinetobacter calcoAngiotensin Converting Enzymeticus (MIC: >128 µg/ml), Proteus vulgaris (MIC: 32-64 µg/ml), Proteus mirabilis (MIC: 32-128 µg/ml), Enterobacter cloacae (MIC: 4-8 µg/ml), Enterobacter aerogenes (MIC: 2-4 µg/ml), Serratia marcescens (MIC: 8-16 µg/ml), Serratia marcescens (MIC: 8-16 µg/ml), Pseudomonas aeruginosa (MIC: >128 µg/ml), Klebsiella oxytoca (MIC: 32-64 µg/ml), Klebsiella aerogenes (MIC: 16-32 µg/ml), Citrobacter freundii (MIC: >128 µg/ml), Escherichia coli (MIC: 4-8 µg/ml), Escherichia coli (MIC: 4-8 µg/ml), Enterococcus faecium (MIC: 2-8 µg/ml), Streptococcus pneumoniae (MIC: 16-32 µg/ml), Staphylococcus haemolyticus (MIC: 8-16 µg/ml), Staphylococcus epidermidis (MIC: 16-32 µg/ml), Staphylococcus aureus (MIC: 4-8 µg/ml), Staphylococcus aureus (MIC: 4-16 µg/ml), Human lung carcinoma A549 |
| IC50 value | --NA-- |
| Sequence | QWGRRCCGWGPGRRYCRRWC |
| Sequence Length | 20 |
| Validation | Experimental evidence at protein level |
| Average Molecular Weight (Da) | 2542.97 |
| Monoisotopic Molecular Weight (Da) | 2541.15 |
| Isoelectric Point (pI) | 10.66 |
| Method / Extraction | --NA-- |
| External links (Uniprot, PDB and Source Information Database) |
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| Uniprot | O24006 |
| NCBI | 2342597 |
| EMBL | --NA-- |
| Link to Source Databases | DBAASP_2434, PhytAMP_PHYT00268, EROP-Moscow_02316, CAMPSQ670, APD_00519 |
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| Addtional Information | The N-terminal glutamine is believed to be cyclized (i.e., pyroglutamate, XXQ). It contains two disulfide bonds (6-16 and 7-20). A recombinant form is active against clinical multiresistant isolates including MRSA (S. aureus) and extended spectrum ±-lactamases-producing E. coli ( Fan X et al., 2013). Activity and sequence relationship was investigated (Peptides. 2005 Jul;26(7):1113-9). Updated 5/30/2013; Synthesis Type : Ribosomal|shows 8% Inhibition against Human lung carcinoma A549 at 200 ¼g/ml, Antimicrobial assays shows that it could efficiently target clinical multiresistant isolates including methicillin-resistant Staphylococcus aureus and extended-spectrum ±-lactamase-producing E. Coli. |
