Detailed Peptide Information
This page shows detailed information of individual peptides present in PlantPepDB database. The page is majorly divided into 3 sections. The first sections contains primary information like peptide activity, source, sequence, etc. In the secondary information section user can access the tertiary structure as well as the physico-chemical properties by clicking the respective links. Further there is also link of the source database and research article from which the peptide data is retrieved. Download the information by clicking
| Primary Information |
|---|
| PPepDB ID | PPepDB_2172 |
| Peptide Name | Viba 15 |
| PMID(s) | 21723349, 25815333, 26399495 |
| Plant Source (Scientific Name) | Viola tricolor, Viola baoshanensis, Viola philippica |
| Plant Source (Common Name) | heartsease, Violet, Chinese Voilet |
| Plant Family | Violaceae |
| Peptide Family | Cyclotide |
| Peptide Function | Anticancer, Cytotoxic, Antimicrobial |
| Peptide Function Description | Shown to possess cytotoxic activity, Target site- Lipid Bilayer; Human foreskin fibroblasts HFF-1(IC50: 2.38 ±0.09 µM), Shows innate immune defense mechanism to treat infections caused by pathogenic bacteria to animals and humans. Display anticancer activities because of their ability to inactivate a wide range of cancer cells. Induce the production of reactive oxygen species (ROS) and cell membrane permeabilization |
| Activity Against | Human skin melanomaMM96L(IC50: 3.10 ±0.06 µM), Human cervical carcinoma HeLa(IC50: 10.21 ±0.43 µM), Human gastric cancer BGC-823(IC50: 1.32 ±0.15 µM) |
| IC50 value | 3.10 ±0.06 µM | 10.21 ±0.43 µM | 1.32 ±0.15 µM |
| Sequence | GLPVCGETCVGGTCNTPGCACSWPVCTRN |
| Sequence Length | 29 |
| Validation | Experimental evidence at transcript level |
| Average Molecular Weight (Da) | 2886.32 |
| Monoisotopic Molecular Weight (Da) | 2884.19 |
| Isoelectric Point (pI) | 5.96 |
| Method / Extraction | MS |
