Detailed Peptide Information
This page shows detailed information of individual peptides present in PlantPepDB database. The page is majorly divided into 3 sections. The first sections contains primary information like peptide activity, source, sequence, etc. In the secondary information section user can access the tertiary structure as well as the physico-chemical properties by clicking the respective links. Further there is also link of the source database and research article from which the peptide data is retrieved. Download the information by clicking
| Primary Information |
|---|
| PPepDB ID | PPepDB_2155 |
| Peptide Name | Cy-AMP1 |
| PMID(s) | 18778743, 19466694 |
| Plant Source (Scientific Name) | Cycas revoluta |
| Plant Source (Common Name) | Sago palm |
| Plant Family | Cycadaceae |
| Peptide Family | Defensin |
| Peptide Function | Antibacterial, Antifungal |
| Peptide Function Description | Target site- Lipid Bilayer; inhibits growth of plant pathogenic fungi, Gram positive, Shows high antimicrobial activity |
| Activity Against | Clavibacter michiganensis subsp. michiganensis (IC50: 7.3 µg/ml), Curtobacterium flaccumfaciens pv. oortii (IC50: 8.9 µg/ml), Agrobacterium radiobacter (IC50: 8.3 µg/ml), Agrobacterium rhizogenes (IC50: 8.5 µg/ml), Erwinia carotovora subsp. carotovora (IC50: 6.0-8.0 µg/ml), Fusarium oxysporum(IC50: 6.0 µg/ml), Geotrichum candidum(IC50: 7.4 µg/ml), Fusarium oxysporum f. sp. cucumerium (IC50: 6.0 µg/ml), Geotrichum candidum (IC50: 7.4 µg/ml), Lactococcus lactis subsp. lactis (IC50: 10 µg/ml), Streptococcus mutans (IC50: 8.0 µg/ml), Clavibacter michiganensis (IC50: 5.0 µg/ml), Enterobacter cloacae (IC50: 8.5 µg/ml) |
| IC50 value | 7.3 µg/ml | 8.9 µg/ml | 8.3 µg/ml | 8.5 µg/ml | 6.0-8.0 µg/ml | 6.0 µg/ml | 7.4 µg/ml | 6.0 µg/ml | 7.4 µg/ml | 10 µg/ml | 8.0 µg/ml | 5.0 µg/ml | 8.5 µg/ml |
| Sequence | KGAPCAKKPCCGPLGHYKVDCSTIPDYPCCSKYGFCGSGPQYCG |
| Sequence Length | 44 |
| Validation | Experimental evidence at protein level |
| Average Molecular Weight (Da) | 4591.34 |
| Monoisotopic Molecular Weight (Da) | 4587.97 |
| Isoelectric Point (pI) | 8.47 |
| Method / Extraction | --NA-- |
| External links (Uniprot, PDB and Source Information Database) |
|---|
| Uniprot | --NA-- |
| NCBI | --NA-- |
| EMBL | --NA-- |
| Link to Source Databases | DBAASP_5257, EROP-Moscow_07360, CAMPSQ3127, APD_01243 |
|---|
| Addtional Information | Synthesis Type: Ribosomal; Mutational studies suggest that the chitin-binding domain plays an essential role in antifungal, but not antimicrobial, activity of Cy-AMP1 (Tokoyama et al 2009 J Pept Sci 15: 492-7). |
