Detailed Peptide Information
This page shows detailed information of individual peptides present in PlantPepDB database. The page is majorly divided into 3 sections. The first sections contains primary information like peptide activity, source, sequence, etc. In the secondary information section user can access the tertiary structure as well as the physico-chemical properties by clicking the respective links. Further there is also link of the source database and research article from which the peptide data is retrieved. Download the information by clicking
| Primary Information |
|---|
| PPepDB ID | PPepDB_2153 |
| Peptide Name | Vv-AMP1 |
| PMID(s) | 17721507, 18611251 |
| Plant Source (Scientific Name) | Vitis vinifera |
| Plant Source (Common Name) | Grape |
| Plant Family | Vitaceae |
| Peptide Family | Defensin |
| Peptide Function | Antimicrobial, Antifungal |
| Peptide Function Description | Target site- Lipid Bilayer; shows strong antifungal activity against a broad spectrum of plant pathogenic fungi, with very high levels of activity against the wilting disease causing pathogens Fusarium oxysporum and Verticillium dahliae. |
| Activity Against | Fusarium oxysporum (IC50: 6 µg/ml), Verticillium dahliae (IC50: 1.8 µg/ml), Fusarium solani(IC50: 9.6 µg/ml), Botrytis cinerea(IC50: 13 µg/ml), Alternaria longipes |
| IC50 value | 6 µg/ml | 1.8 µg/ml | 9.6 µg/ml | 13 µg/ml |
| Sequence | RTCESQSHRFKGTCVRQSNCAAVCQTEGFHGGNCRGFRRRCFCTKHC |
| Sequence Length | 47 |
| Validation | Experimental evidence at protein level |
| Average Molecular Weight (Da) | 5355.08 |
| Monoisotopic Molecular Weight (Da) | 5351.38 |
| Isoelectric Point (pI) | 9.37 |
| Method / Extraction | --NA-- |
| External links (Uniprot, PDB and Source Information Database) |
|---|
| Uniprot | D7TAI4, A7QBX4 |
| NCBI | --NA-- |
| EMBL | --NA-- |
| Link to Source Databases | DBAASP_5851, EROP-Moscow_07214, CAMPSQ3166, APD_01330 |
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| Addtional Information | Synthesis Type: Ribosomal; Activity is associated with membrane permeabilization; Not active at > 20 ¼g/ml-Alternaria longipes; It shows sequence homology to plant defensins. Recombinant Vv-AMP1 was extremely heat-stable and showed strong antifungal activity against a broad spectrum of plant pathogenic fungi, with very high levels of activity against the wilting disease causing pathogens Fusarium oxysporum and Verticillium dahliae. |
