Detailed Peptide Information
This page shows detailed information of individual peptides present in PlantPepDB database. The page is majorly divided into 3 sections. The first sections contains primary information like peptide activity, source, sequence, etc. In the secondary information section user can access the tertiary structure as well as the physico-chemical properties by clicking the respective links. Further there is also link of the source database and research article from which the peptide data is retrieved. Download the information by clicking
| Primary Information |
|---|
| PPepDB ID | PPepDB_2139 |
| Peptide Name | Cyclosaplin |
| PMID(s) | 24503375 |
| Plant Source (Scientific Name) | Santalum album |
| Plant Source (Common Name) | Indian sandalwood |
| Plant Family | Santalaceae |
| Peptide Family | Cyclic Peptide |
| Peptide Function | Anticancer, Hemolytic, Cytotoxic |
| Peptide Function Description | Target site- Lipid Bilayer; Not active up to 1000 µg/ml- Mouse fibroblasts L929 |
| Activity Against | Human breast adenocarcinoma MDA-MB-231(IC50: 2.06 µg/ml) |
| IC50 value | 2.06 µg/ml |
| Sequence | RLGDGCTR |
| Sequence Length | 8 |
| Validation | Experimental evidence at protein level |
| Average Molecular Weight (Da) | 876.99 |
| Monoisotopic Molecular Weight (Da) | 876.42 |
| Isoelectric Point (pI) | 8.25 |
| Method / Extraction | --NA-- |
| External links (Uniprot, PDB and Source Information Database) |
|---|
| Uniprot | --NA-- |
| NCBI | --NA-- |
| EMBL | --NA-- |
| Link to Source Databases | DBAASP_4301, EROP-Moscow_13022, APD_02340 |
|---|
| Addtional Information | Synthesis Type: Ribosomal; Active against Cancer cells MDA-MB-231. It is proposed that the peptide sensitizes MDA-MB-231 cells by possibly binding to EGFR and induces apoptosis. |
