Detailed Peptide Information
This page shows detailed information of individual peptides present in PlantPepDB database. The page is majorly divided into 3 sections. The first sections contains primary information like peptide activity, source, sequence, etc. In the secondary information section user can access the tertiary structure as well as the physico-chemical properties by clicking the respective links. Further there is also link of the source database and research article from which the peptide data is retrieved. Download the information by clicking
| Primary Information |
|---|
| PPepDB ID | PPepDB_2127 |
| Peptide Name | Vaby D |
| PMID(s) | 21434649, 20558471, PPepDB_2127_ref1 |
| Plant Source (Scientific Name) | Viola abyssinica |
| Plant Source (Common Name) | --NA-- |
| Plant Family | Violaceae |
| Peptide Family | Cyclotide |
| Peptide Function | Antibacterial, Antifungal, Cytotoxic |
| Peptide Function Description | Shows potent cytotoxic activity in cancer cells; Target site- Lipid Bilayer; Participate in the innate immune response of plants, therapeutically useful as anticancer agents and novel antimicrobial compounds in the protection of crops to the disinfection of hospital environments. |
| Activity Against | Human histiocytic lymphoma U-937/GTB(IC50: 2.6 µM), Salmonella enterica serovar Typhimurium (MIC: >90 µM), Escherichia coli (MIC: 50 µM), Staphylococcus aureus (MIC: >90 µM) |
| IC50 value | 2.6 µM |
| Sequence | GLPVCGETCFGGTCNTPGCTCDPWPVCTRN |
| Sequence Length | 30 |
| Validation | Experimental evidence at protein level |
| Average Molecular Weight (Da) | 3089.51 |
| Monoisotopic Molecular Weight (Da) | 3087.25 |
| Isoelectric Point (pI) | 4.37 |
| Method / Extraction | Amino acid analysis, MS |
| External links (Uniprot, PDB and Source Information Database) |
|---|
| Uniprot | --NA-- |
| NCBI | --NA-- |
| EMBL | --NA-- |
| Link to Source Databases | DBAASP_5815, Cybase_561, CAMPSQ3505, APD_01785 |
|---|
| Addtional Information | Synthesis Type: Ribosomal; Five new cyclotides were isolated and two were evaluated for anticancer activity. |
