Detailed Peptide Information
This page shows detailed information of individual peptides present in PlantPepDB database. The page is majorly divided into 3 sections. The first sections contains primary information like peptide activity, source, sequence, etc. In the secondary information section user can access the tertiary structure as well as the physico-chemical properties by clicking the respective links. Further there is also link of the source database and research article from which the peptide data is retrieved. Download the information by clicking
| Primary Information |
|---|
| PPepDB ID | PPepDB_2115 |
| Peptide Name | Cliotide T15 |
| PMID(s) | 27007913 |
| Plant Source (Scientific Name) | Clitoria ternatea |
| Plant Source (Common Name) | Asian pigeonwings |
| Plant Family | Fabaceae |
| Peptide Family | Cyclotide |
| Peptide Function | Antibacterial |
| Peptide Function Description | Target site- Lipid Bilayer; Cationic cliotides display potent antibacterial activity against Gram-negative bacteria. It also possess prominent immunostimulating activity. Cationic cliotides are capable of secretion of various cytokines and chemokines in human monocytes at both resting and lipopolysaccharide-stimulated states. Hence also used as potential candidates for novel immunomodulating therapeutics. |
| Activity Against | Escherichia coli (MIC: 0.5 µM), Escherichia coli (MIC: 2.5 µM), Staphylococcus aureus, Caenorhabditis elegans |
| IC50 value | --NA-- |
| Sequence | GLPICGETCFKTKCYTKGCSCSYPVCKRN |
| Sequence Length | 29 |
| Validation | Experimental evidence at transcript level |
| Average Molecular Weight (Da) | 3190.79 |
| Monoisotopic Molecular Weight (Da) | 3188.44 |
| Isoelectric Point (pI) | 8.89 |
| Method / Extraction | NGS, MS |
| External links (Uniprot, PDB and Source Information Database) |
|---|
| Uniprot | A0A0S1RSI4 |
| NCBI | --NA-- |
| EMBL | --NA-- |
| Link to Source Databases | DBAASP_9052, Cybase_968, APD_02685 |
|---|
| Addtional Information | Synthesis Type: Ribosomal; Not active up to 100 µM- Staphylococcus aureus ; Evidence for bactericidal activity- membrane disruption of E. coli. (Nguyen et al., 2016) Observed PTMs: N-terminal acetylation, de-amidation N29. (Serra et al., 2016) Highly expressed in C. ternatea root and pod. (Gilding et al., 2016); APD analysis reveals that the sequence of THE PEPTIDE shows 77.4% similarity to Cycloviolacin O15. Active against E. coli (MIC 0.5 uM). |
