Detailed Peptide Information
This page shows detailed information of individual peptides present in PlantPepDB database. The page is majorly divided into 3 sections. The first sections contains primary information like peptide activity, source, sequence, etc. In the secondary information section user can access the tertiary structure as well as the physico-chemical properties by clicking the respective links. Further there is also link of the source database and research article from which the peptide data is retrieved. Download the information by clicking
| Primary Information |
|---|
| PPepDB ID | PPepDB_2107 |
| Peptide Name | Mela 4 |
| PMID(s) | 26322745 |
| Plant Source (Scientific Name) | Melicytus latifolius |
| Plant Source (Common Name) | Norfolk Island mahoe |
| Plant Family | Violaceae |
| Peptide Family | Cyclotide |
| Peptide Function | Antibacterial, Anticancer, Cytotoxic |
| Peptide Function Description | Shows cytotoxocity against cancer cell lines and low toxicity against red blood cells, Target site- Lipid Bilayer; Human foreskin fibroblasts HFF-1(CC50: 5.39 ±0.33 µM) |
| Activity Against | Escherichia coli, Staphylococcus aureus, Human skin melanoma MM96L(CC50: 2.04 ±0.26 µM), Human cervical carcinoma HeLa(CC50: 18.73 ±1.82 µM)/ Cancer cell lines and red blood cells |
| IC50 value | --NA-- |
| Sequence | GKPICGETCFKGKCYTPGCTCSYPICKKN |
| Sequence Length | 29 |
| Validation | Experimental evidence at protein level |
| Average Molecular Weight (Da) | 3130.74 |
| Monoisotopic Molecular Weight (Da) | 3128.41 |
| Isoelectric Point (pI) | 8.87 |
| Method / Extraction | Amino acid analysis |
| External links (Uniprot, PDB and Source Information Database) |
|---|
| Uniprot | C0HK31 |
| NCBI | --NA-- |
| EMBL | --NA-- |
| Link to Source Databases | DBAASP_10543, Cybase_1023 |
|---|
| Addtional Information | Synthesis Type: Ribosomal; Not active up to 64 µM-Escherichia coli, Staphylococcus aureus/ I/L determined on the basis of AAA ratios. Membrane binding studies show preference for phosphatidylethanolamine (PE)-phos- pholipid-containing lipids. Cytotoxicity and antibacterial activity have also been assayed. (Ravipati et al. 2015) |
