Detailed Peptide Information
This page shows detailed information of individual peptides present in PlantPepDB database. The page is majorly divided into 3 sections. The first sections contains primary information like peptide activity, source, sequence, etc. In the secondary information section user can access the tertiary structure as well as the physico-chemical properties by clicking the respective links. Further there is also link of the source database and research article from which the peptide data is retrieved. Download the information by clicking
| Primary Information |
|---|
| PPepDB ID | PPepDB_2104 |
| Peptide Name | Coccinin |
| PMID(s) | 15572193, 25815333 |
| Plant Source (Scientific Name) | Phaseolus coccineus |
| Plant Source (Common Name) | Runner bean |
| Plant Family | Fabaceae |
| Peptide Family | Defensin |
| Peptide Function | Antiviral, Anticancer, Antifungal, Hemolytic, Antiproliferative, HIV-1-reverse-transcriptase-inhibition |
| Peptide Function Description | Target site: lipid bilayer; Mouse splenocytes; It has antifungal activity on a number of fungal species. It also inhibit the proliferation in the leukemia cell lines HL60 and L1210, and reduced the activity of HIV-1 reverse transcriptase. |
| Activity Against | Mycosphaerella arachidicola (IC50: 75 ± 5 µM), Fusarium oxysporum (IC50: 81 ± 7 µM), Physalospora piricola (IC50: 89 ± 4 µM), Botrytis cinerea (IC50: 109 ± 5 µM), Coprinus comatus (IC50: 122 ± 7 µM), Rhizoctonia solani (IC50: 134 ± 2 µM), HIV-1 (IC50: 41 µM), Mouse lymphocytic leukemia L1210 (IC50: 40 µM), Human promyelocytic leukemia HL-60 (IC50: 30 µM) |
| IC50 value | 75 ± 5 µM | 81 ± 7 µM | 89 ± 4 µM | 109 ± 5 µM | 122 ± 7 µM | 134 ± 2 µM | 41 µM | 40 µM | 30 µM |
| Sequence | KQTENLADTY |
| Sequence Length | 10 |
| Validation | Experimental evidence at protein level |
| Average Molecular Weight (Da) | 1182.25 |
| Monoisotopic Molecular Weight (Da) | 1181.56 |
| Isoelectric Point (pI) | 4.37 |
| Method / Extraction | --NA-- |
| External links (Uniprot, PDB and Source Information Database) |
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| Uniprot | P84785 |
| NCBI | 90183454 |
| EMBL | --NA-- |
| Link to Source Databases | DBAASP_1665, CAMPSQ652 |
|---|
| Addtional Information | Synthesis Type : Ribosomal |
