Detailed Peptide Information
This page shows detailed information of individual peptides present in PlantPepDB database. The page is majorly divided into 3 sections. The first sections contains primary information like peptide activity, source, sequence, etc. In the secondary information section user can access the tertiary structure as well as the physico-chemical properties by clicking the respective links. Further there is also link of the source database and research article from which the peptide data is retrieved. Download the information by clicking
| Primary Information |
|---|
| PPepDB ID | PPepDB_2103 |
| Peptide Name | Piceain 2 |
| PMID(s) | 21644248 |
| Plant Source (Scientific Name) | Picea sitchensis |
| Plant Source (Common Name) | Sitka spruce |
| Plant Family | Pinaceae |
| Peptide Family | --NA-- |
| Peptide Function | Antibacterial, Antifungal, Nematocide |
| Peptide Function Description | Target site: lipid bilayer; shows 1% Hemolysis against Human erythrocytes at 125 µg/ml; shows 5% Hemolysis against Human erythrocytes at 500 µg/ml; shows 11% Hemolysis against Human erythrocytes at 1000 µg/ml; shows 2% Hemolysis against Rabbit erythrocytes at 62.5 µg/ml; shows 5% Hemolysis against Rabbit erythrocytes at 250 µg/ml; shows 12% Hemolysis against Rabbit erythrocytes at 500 µg/ml; shows 66% Hemolysis against Rabbit erythrocytes at 1000 µg/ml |
| Activity Against | Staphylococcus aureus (MIC: 9.38 µg/ml), Staphylococcus aureus (MIC: 9.38 µg/ml), Bacillus subtilis (MIC: >100 µg/ml), Candida albicans (MIC: 18.75 µg/ml), Escherichia coli (MIC: 37.5 µg/ml), Escherichia coli (MIC: 37.5 µg/ml), Escherichia coli (MIC: 75 µg/ml), Escherichia coli (MIC: 37.5 µg/ml), Pseudomonas aeruginosa (MIC: 9.38 µg/ml), Pseudomonas aeruginosa (MIC: 18.75 µg/ml), Pseudomonas aeruginosa (MIC: 37.5 µg/ml), |
| IC50 value | --NA-- |
| Sequence | RPRCWIKIKFRCKSLKF |
| Sequence Length | 17 |
| Validation | Experimental evidence at protein level |
| Average Molecular Weight (Da) | 2209.79 |
| Monoisotopic Molecular Weight (Da) | 2208.27 |
| Isoelectric Point (pI) | 11.08 |
| Method / Extraction | --NA-- |
| External links (Uniprot, PDB and Source Information Database) |
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| Uniprot | A9P048, A9NLH1 |
| NCBI | --NA-- |
| EMBL | --NA-- |
| Link to Source Databases | DBAASP_3944, CAMPSQ3492, APD_01770 |
|---|
| Addtional Information | Synthesis Type : Ribosomal|shows 56% Killing against Caenorhabditis elegans at 100 ¼g/ml|shows 51% Killing against Caenorhabditis elegans at 10 ¼g/ml ; Active against E. coli, P. aeruginosa, S. aureus, and fungus C. albicans. It showed weak hemolysis activity. Since piceain 1 contains three additional residues at the N-terminus, it remains to be established whether piceain 2 is a natural form or simply a derivative of piceain 1. CD suggests a beta structure. Updated 4/29/14. |
