'PtRNAdb' is a plant exclusive database dedicated to tRNA genes identified in phylogenetically diverse plant species. We have analysed a total of 106 nuclear and 127 organellar (38 mitochondrial and 89 plastid) genomes available at National Center for Biotechnology Information with a highly accurate software package: tRNAscan-SE for the detection of tRNA genes. We have analysed the sequences of only chromosome level for nuclear genomes and complete sequences for organeller genomes. A total of 113849 tRNA gene sequences with consensus based structure and other related informations are available at this database. 'PtRNAdb' is believed to be highly beneficial for the exploration of diverse plant tRNAnome and aid in further revelation of new functions of transfer RNAs.
Transfer ribonucleic acid (tRNA) is a type of RNA molecule that helps decode a messenger RNA (mRNA) sequence into a protein. tRNAs function at specific sites in the ribosome during translation, which is a process that synthesizes a protein from an mRNA molecule. Proteins are built from smaller units called amino acids, which are specified by three-nucleotide mRNA sequences called codons. Each codon represents a particular amino acid, and each codon is recognized by a specific tRNA.
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The tRNA molecule has a distinctive folded structure with three hairpin loops that form the shape of a three-leafed clover. One of these hairpin loops contains a sequence called the anticodon, which can recognize and decode an mRNA codon. Each tRNA has its corresponding amino acid attached to its end. When a tRNA recognizes and binds to its corresponding codon in the ribosome, the tRNA transfers the appropriate amino acid to the end of the growing amino acid chain. Then the tRNAs and ribosome continue to decode the mRNA molecule until the entire sequence is translated into a protein. However, recent studies suggest that the roles of tRNA in cellular regulation go beyond this paradigm. Now, tRNA is recognized as a regulator of many biological processes, and several unique tRNA genes have been discovered.
Isoacceptors and isodecoders, tRNA base modifications, pseudogenes, diverse protein binding potential and tRNA-derived fragments have collectively made the tRNA world more complex and challenging. tRNA can now be considered as multifunctional species responsible for affecting overall cellular genomics by maintaining cellular milieu and adaptation to various kinds of stresses in a universal manner.
Statistical information of PtRNAdb
Methodologies opted for PtRNAdb development
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© Developed by Dr. Shailesh Laboratory | National Institute of Plant Genome Research (NIPGR), New Delhi, India | DBT
