<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP34048

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMMSNYGNMMDSPKSSPHGGGRSPVVARQDSSGTLKTTISLGKTPTIIHTGPFYSMKEPPAKAELTGDKDLMTEYGLHHTLTKFKEKKFKESLASFLQNIPGINDLITHPVENSTLRSVIEKPPIGGKELLPLTPVQLAGFRLHPGPLPEQYRTTYVTPARKHKNKHKKQKHKDGVTTGQESTLLDSAGLETYEKKHKKQKRHEDDKERKKRKKEKKRKKKNQSPEPGVGLLPGGASLGGAAGVMGATSLGSLGGGPGGPGLSSLSASMGPGVVGNMNSFSSSMQMQQQQQMPMQQQQMSSGGLLGSVLGTSGGPGGGGGGGGGGGGGVGGSLLMSQF
Length337
PositionHead
OrganismDrosophila melanogaster (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.04
Grand average of hydropathy-0.701
Instability index58.88
Isoelectric point9.93
Molecular weight35389.99
Publications
PubMed=10731132
PubMed=12537568
PubMed=12537572
PubMed=12537573
PubMed=12537574
PubMed=16110336
PubMed=17569856
PubMed=17569867

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP34048
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.55|      27|      70|     229|     267|       1
---------------------------------------------------------------------------
  229-  260 (46.60/17.04)	GLLPGGASLG..................GAAGVmgatsLGSLGGGPGGPG
  271-  315 (37.95/12.19)	GVVGNMNSFSssmqmqqqqqmpmqqqqmSSGGL.....LGSVLGTSGGPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.73|      14|      20|     194|     207|       2
---------------------------------------------------------------------------
  194-  207 (26.68/14.66)	KKHKKQKRHEDDKE
  212-  225 (23.05/11.86)	KKEKKRKKKNQSPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     125.61|      33|      33|      40|      72|       3
---------------------------------------------------------------------------
   16-   36 (21.60/ 6.80)	...........PHGGGRSPvVAR..QDSSG..TLKT
   40-   72 (58.77/29.59)	LGKTPTIIHTGPFYSMKEP.PAK..AELTGDKDLMT
   76-  107 (45.24/21.30)	LHHTLTKFKEKKF...KES.LASflQNIPGINDLIT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.39|      17|      22|     123|     143|       4
---------------------------------------------------------------------------
  123-  143 (20.62/20.86)	PIGgkELLPLTPVQLAgfRLH
  146-  162 (31.76/16.55)	PLP..EQYRTTYVTPA..RKH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP34048 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MMSNYGNMMDSPKSSPHGGGRSPVVARQDSSGTLKTTISL
2) PLPEQYRTTYVTPARKHKNKHKKQKHKDGVTTGQESTLLDSAGLETYEKKHKKQKRHEDDKERKKRKKEKKRKKKNQSPEPGVGLLPGGASLGGAAGVMGATSLGSLGGGPGGPGLSSLSASMGPGVVGNMNSFSSSMQMQQQQQMPMQQQQMSSGGLLGSVLGTSGGPGGGGGGGGGGGGGVG
1
146
40
329










Molecular Recognition Features






MoRF SequenceStartStop




1) GLLGSVLGT
2) GVGGSLLMSQF
302
327
310
337