<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP34040

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMETSEYETNTLSINNIASITFRIYEPPPDQSHGFQSSALEIQSSLRDQGKLVSYDADRVGIWIFQIVSKDGTSKAVNSAPGSSLEASGYTLGMVEEGNLEPVALQKSRIPGNTTQNAPNNTASTASPAEANSRNPLISPTQVAGGALPEGVSQSSAQVTDMRTTQPVPKIIYEQFIVAVISSIAFAFCSRSMAIPLNYRTMLIPPLLADANERERGSLQADPVVGTFKTYLTTTGSLVVSLTFSYCKNLATVEDVLTGDSSSPSSSVLAAPYGVFATKQNFANGDGSDRSLAQTPNTQALSVRSVPDTNDSQWKHSCLKALEYCGLNPSQFKASPWVNLLISKPTSQDADGESKRSRATVPWPGSLCFRKKPMEMSTTHRVGDTMLSGHEECHDPLGDARGWFAGASEREERISKRKAERMYAVTREVNATPMADAENDAWGGQHEQKRERSDSNAMGDSDDVMNDLGEDVFGDHDVTEDDFNFFDGPDGNDLDMDMPDLQPAPTAPAPQVMPPPVLSHPEPHKAIQPQPEVKPKPKTNDSVFAKPELKHARSSLNDELNHRIKVERPDTAKRGSSPFDPATVFKRVRASLSSPTKDDFAVQPPRRKSSVFEKVEFDPKIPLINKKYEHGGAFDFSKDQSNGDSRPSAHNLSRDEYLEGQGKLKQTSKSLLGNSLIRSLTGIDASTTHASPQRLNGHDWISEESELESDGDDISSLSGGPVSPVKSSIKRTVVDDDALSQATTSRETELLDDVTDEQLAIELPKLSKTESPEMLLHRFFLDPEPLNVDVGLSNHDFVEIAQIITEQAATGRLEIGIEHKAESSVSLATMRSHELSIARNSLQLLHDAIPSNLGTPTAVRLKGLLEIQDLPLVGQPSRLQPRPIPGRDPNAEQLRANNLYQIPVPHLEVRRSETKLSVLPSSMSFWEGLGLSPSWGTKDISALCIFPGWKGMSDHVESFLSRLKSVYESLKLGTLNNLPLSGDWDDGVLPYEVDRISTSPDATVTGHGSALVESMEVLRSSLSELKSKDKNLVIYFVYSPDNPASIIEACTAFYRCFDEYSDLLAARRESPQNELVLQLVSLDMISSTTSLVVPTPAEMIKLCIETYDRCTLFLDTEFGGPTPAPAVMLEQPPPRMIDFKLTTSPSQSLMHENSCLHVGYAESLDGRWITAAWTDNRGQRQATTSYSITRSRTPDRSVSHHKAAIIAEIWATTLTMISIWKVHWRVIITKSGAMDQKEVEWWQAASTLDDKHSFTMILMSVDTNPSLQLVPPIVKIPHAATSAFYSTPVSTPQANIVSPEQTTTPATPMRDASTLAATPTAEGAAEAEADSFLIDATDQTWGAIVGHRLCNSTTLLEVRPALASGYLIKRTGIKLEDPPVVMEVNLVHTEATPRAYEPLLREMLCYFRGLGTLARARGVVDREMDVRPWHIAAAEKGVRALHLLL
Length1444
PositionKinase
OrganismFusarium oxysporum f. sp. raphani 54005
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium oxysporum species complex.
Aromaticity0.06
Grand average of hydropathy-0.388
Instability index47.09
Isoelectric point5.21
Molecular weight158081.84
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP34040
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1009.68|     427|     615|      24|     515|       1
---------------------------------------------------------------------------
   24-  357 (361.56/328.20)	...............................................................................................................................................................................................................................................................................................Y.EPPPDQSHG.FQSSALEIQSS..LRDQGKL.VSYDADRVGIWIFQIVSKD.GTSKAVNSAPG............SSLEASGYTLGMVEEGNLEPValqKSRIPGNTTQNAPNNTASTASPAEANSRnplISPTQVAgGALPEgvsqssaqvtdMRTTQPvPKIIYEQFIvavissiaFAFCSRSMAIPL.NYRTMLIPPLLADanERERGSLQadpvVG.TFKTYLTTTGSLVVSLTFSYCKN.LATVEDVLTGDSSSPSSSVLAapyGVFATKQNFANGDGS...DRSL.AQTPNTQAL...SVRSVP....DTNDSQWKHSCLkaleycglnPSQFkaSPWVNLLISkPT..SQDAD......GESKRSR
  358-  512 (107.47/92.16)	ATVPWPGSLCFRKKPMEMSTTHRVGDTMLSGHeecHDPLgdARGWFAGASEREERISKRKAERMYAVTREVNATPMADAEN......DAWGGQHEQKRErSDSNAMgdsddVMNDLGEDVFGDHD..VTEDDFNF....FDGPDGNDLDMDMPdlQPAPTaPAPQVM..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  633-  953 (337.69/210.82)	.......................................................................................................................................................................pppvlshpephkaiqpqpevkpkpktndsvfakpelkharsslndelnhrikverpdtakrgsspfdpatvfkrvraslssptkddfavqpprrkssvfekvefdpkiplinkkyehggaF.DFSKDQSNGdSRPSAHNLSRDeyLEGQGKL.KQTSKSLLGNSL..IRSLT.GIDASTTHASPqrlnghdwiseeSELESDGDDISSLSGGPVSPV...KSSIKRTVVDDDALSQATTSRETELLDD...VTDEQLA.IELPK...........LSKTES.PEMLLHRFF........LDPEPLNVDVGLsNHDFVEIAQIITE..QAATGRLE....IGiEHKAESSVSLATMRSHELSIARNsLQLLHDAIPSNLGTPTAVRLK...GLLEIQDLPLVGQPSrlqPRPIpGRDPNAEQLranNLYQIPvphlEVRRSETKLSVL.........PSSM..SFWEGLGLS.PSwgTKDISalcifpGWKGMSD
  975- 1184 (202.97/112.62)	NNLPLSGDWDDGVLPYEVDRISTSPDATVTGH...GSAL..VESMEVLRSSLSELKSKDKNLVIYFVYSPDNPASIIEACTafyrcfDEYSDLLAARRE.SPQNEL.....VLQLVSLDMISSTTslVVPTPAEMiklcIETYDRCTLFLDTE..FGGPT.PAPAVM.........................................................................................................................lEQPPPRMID.FKLTTSPSQSL..MHENSCLhVGYAESLDGRWITAAWTDNrGQRQATTS.........................................................................................................................................................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.99|      13|      21|     545|     557|       3
---------------------------------------------------------------------------
  545-  557 (22.21/12.34)	KPELKHARSSLND
  567-  579 (23.77/13.75)	RPDTAKRGSSPFD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP34040 with Med13 domain of Kingdom Fungi
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