<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP34034

Description Uncharacterized protein
SequenceMPDQNHTPSRFPPSRHDTSQPTDPKPQYEIPSTLSAKVLTLDTPISFPGMEHIMKTSGAAKRLPKEHGIRHRGQINAPSTFKPPPRVTLTDTKREVWLKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKNVPAERAVWLAKCVGANEIRGLKRKGVNGAFVMGGELKWARDWTVFVEQFVDAVVAGFGENDWKNRVTYAIRLATNLYSEQLLDRDHYLDWVVSGIENSLQSRIPMWLLIAQIYWKDLLRSRKYGRRLVFALLSHLHVISNDPDQDLLVQLSSRLSALLGSLIRSNPESFINPGAWSTYKDTLHACLRSDDEQARKALHAINSRNSRLVVSSTASPPAGRSQLVKLLDAALKESSDNHLAAACWATSENKSLIMKTVVEWATSFHRPGLAKVYAATRLIRQWSQFRVNPTTPILETLDNIAANDKARKNLVYHLVTELVRTGHFSVSQYMQWTIARGGYHCAAEIDPVSGPCSSRLLVELPLHALSEKRRAERGNLLRRAGNYSVAEEDQDITNAIRVVKHVVGLPLLSNDPLSGRKPMSLKKLLQRMGGSSTALRSSIGAHLRDELTGQFIMKGHSLSLTMFTAVRDIMEMAEDYAMLSDILGACAKTADSDVLASVADTVHSNLQIFCALDSANELFNSLIERLRMMNEEQRLVPRPLLAALSSLAQRMAGHEVIASQLRQELVQNDRNNAIDACSPVSDIVATPSHQAENNVAEEVERTLSSGTRLDPPTMNKLFRMIIPALERGWEKEDDTRRVFATLLARIRVFDAHHFDKLMTDWTSHIRSISNRSSLSTLFPLLIITGCLTMPIIMSTASPPFANIQNLAPESSRGPATYLQELLQLVIMPLPQATGLVAEESYRFHTEQKCAKFEQSKGLLNLVRNALLEYSTVRNHVNGTEFPLDNLECQESLLETLRTLVLVDSSAVSNALGIKSLPAEAVGLVRKVTTKLLIPGDSGETQISFDHILQIANELTLPFCQLKLNLDLSLPQPSVIEGQDQSSSRFEIFARAMDRAIEAGNIMWTSLLPCLSDDITQHLKTQAQTGFLDLIPSSKAPEFVDTGSRQSLRMAENLLEVVEAIISGQAPPKMAQLSLGMVEKLTDLWEIVAAGPQERPNCHAAVLQHWLPAMLRFVNLHSLSSEPPSAPLPTASATRPPIPPVHDVRARIVLVLCGLLLELETLPPATVGSLVQQVFDIAILLVDALPEELRANCARATLLTPGGMPNQGTSSDPRLYYLFSSPPPSPSDNLMLSHREKAATPQSAAARGMGAQYGIGPVVQERLSPFILRRWEVLSEPTPNVGENDTSLSLGLFEAIKLQ
Length1329
PositionKinase
OrganismFusarium oxysporum f. sp. raphani 54005
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium oxysporum species complex.
Aromaticity0.06
Grand average of hydropathy-0.156
Instability index49.82
Isoelectric point7.64
Molecular weight147007.14
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP34034
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.76|      59|     100|     611|     673|       1
---------------------------------------------------------------------------
  611-  673 (94.11/77.48)	SDILGACAKTADSDVLASVADTVHSNLQifcaLD..SANELFNSLIERL.RMMNEEQ..RLVPRPLLA
  712-  775 (87.66/61.08)	SDIVATPSHQAENNVAEEVERTLSSGTR....LDppTMNKLFRMIIPALeRGWEKEDdtRRVFATLLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     196.82|      47|      47|     314|     360|       2
---------------------------------------------------------------------------
  252-  295 (62.59/35.54)	S.R.....KYG..RRLVFALLSH.....................LHVI....SNDPD.QDLL..VQLSS..RLSALLGSLIR
  296-  345 (50.36/27.16)	SnPesfinPGA..WST........................ykdtLHAC.LR.SDDEQARKAL..HAINS..RNSRLVVSSTA
  346-  389 (54.71/30.14)	S.P.....PAG..RSQLVKLLDA.........................aLKeSSDNHLAAAC..WA.TS..ENKSLIMKTVV
  390-  458 (29.15/12.63)	E.W.....ATSfhRPGLAKVYAAtrlirqwsqfrvnpttpiletLDNI.AA.ND..KARKNLvyHLVTElvRTGHFSVS...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.75|      10|      34|       7|      16|       4
---------------------------------------------------------------------------
    7-   16 (21.51/11.08)	TPSRFPPSRH
   43-   52 (21.24/10.85)	TPISFPGMEH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.07|      23|      34|     191|     214|       5
---------------------------------------------------------------------------
  191-  214 (35.20/25.33)	ENDWKNRVTYAIrLATNLYSEQLL
  228-  250 (41.88/25.65)	ENSLQSRIPMWL.LIAQIYWKDLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.74|      25|      42|      93|     121|       6
---------------------------------------------------------------------------
   93-  121 (36.09/35.21)	KREVWLKDLAnPAISLRRLSRtipHGIRG
  136-  160 (43.66/27.54)	ERAVWLAKCV.GANEIRGLKR...KGVNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.64|      17|      34|     897|     913|       7
---------------------------------------------------------------------------
  897-  913 (29.97/17.85)	LLEYSTVRNHVNGTEFP
  932-  948 (26.66/15.12)	LVDSSAVSNALGIKSLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.17|      29|      47|     468|     512|       8
---------------------------------------------------------------------------
  468-  512 (40.16/50.34)	GGYHcaaeidpvsgpcssrlLVELPL...HALSEKRRAERGNLLRRAG
  529-  560 (46.01/24.60)	VVKH................VVGLPLlsnDPLSGRKPMSLKKLLQRMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.65|      12|     101|    1146|    1157|      10
---------------------------------------------------------------------------
 1146- 1157 (23.23/13.30)	LHSLSSEPPSAP
 1245- 1256 (25.43/15.41)	LYYLFSSPPPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.77|      28|      92|    1106|    1133|      13
---------------------------------------------------------------------------
 1106- 1133 (52.42/27.82)	G.MVEKLTDL.WEIVAAGPQE.RPNCHAAVL
 1198- 1228 (35.35/16.68)	GsLVQQVFDIaILLVDALPEElRANCARATL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP34034 with Med12 domain of Kingdom Fungi
Unable to open file!