<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP34033

Description Uncharacterized protein
SequenceMTSRTTMGAHPRPPQRSVSSSSLPVQRPPPQRSLSHQQQFMAAASPVRKDAPFIDLTADAGDATPNRYHTTPRRGGSRLRLELSHNASSSSLPTSESPQSLTPSRIPNSDPFQAMVGSPAGSASSTLMPMPTRRPVTSQPRFAPRITATAPAPAKKDARPKPYTVEIPSVAPRYFSANRPETAVRNPVDPFSKGLNSGYADFFPWNGAHHEDEWSSEAITKGTWDKVNLNVPETSSAKLAIFPALKQKTGLNALSTIFMGVLTQRRHRGQINAPSTFKPPPRVTLTDTKREVWLKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKNVPAERAVWLAKCVGANEIRGLKRKGVNGAFVMGGELKWARDWTVFVEQFVDAVVAGFGENDWKNRVTYAIRLATNLYSEQLLDRDHYLDWVVSGIENSLQSRIPMWLLIAQIYWKDLLRSRKYGRRLVFALLSHLHVISNDPDQDLLVQLSSRLSALLGSLIRSNPESFINPGAWSTYKDTLHACLRSDDEQARKALHAINSRNSRLVVSSTASPPAGRSQLVKLLDAALKESSDNHLAAACWATSENKSLIMKTVVEWATSFHRPGLAKVYAATRLIRQWSQFRVNPTTPILETLDNIAANDKARKNLVYHLVTELVRTGHFSVSQYMQWTIARGGYHCAAEIDPVSGPCSSRLLVELPLHALSEKRRAERGNLLRRAGNYSVAEEDQDITNAIRVVKHVVGLPLLSNDPLSGRKPMSLKKLLQRMGGSSTALRSSIGAHLRDELTGQFIMKGHSLSLTMFTAVRDIMEMAEDYAMLSDILGACAKTADSDVLASVADTVHSNLQIFCALDSANELFNSLIERLRMMNEEQRLVPRPLLAALSSLAQRMAGHEVIASQLRQELVQNDRNNAIDACSPVSDIVATPSHQAENNVAEEVERTLSSGTRLDPPTMNKLFRMIIPALERGWEKEDDTRRVFATLLARIRVFDAHHFDKLMTDWTSHIRSISNRSSLSTLFPLLIITGCLTMPIIMSTASPPFANIQNLAPESSRGPATYLQELLQLVIMPLPQATGLVAEESYRFHTEQKCAKFEQSKGLLNLVRNALLEYSTVRNHVNGTEFPLDNLECQESLLETLRTLVLVDSSAVSNALGIKSLPAEAVGLVRKVTTKLLIPGDSGETQISFDHILQIANELTLPFCQLKLNLDLSLPQPSVIEGQDQSSSRFEIFARAMDRAIEAGNIMWTSLLPCLSDDITQHLKTQAQTGFLDLIPSSKAPEFVDTGSRQSLRMAENLLEVVEAIISGQAPPKMAQLSLGMVEKLTDLWEIVAAGPQERPNCHAAVLQHWLPAMLRFVNLHSLSSEPPSAPLPTASATRPPIPPVHDVRARIVLVLCGLLLELETLPPATVGSLVQQVFDIAILLVDALPEELRANCARATLLTPGGMPNQGTSSDPRLYYLFSSPPPSPSDNLMLSHREKAATPQSAAARGMGAQYGIGPVVQERLSPFILRRWEVLSEPTPNVGENDTSLSLGLFEAIKLQ
Length1525
PositionKinase
OrganismFusarium oxysporum f. sp. raphani 54005
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium oxysporum species complex.
Aromaticity0.06
Grand average of hydropathy-0.204
Instability index52.34
Isoelectric point8.85
Molecular weight168051.50
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP34033
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     180.26|      59|     101|     807|     869|       1
---------------------------------------------------------------------------
  807-  869 (93.38/73.94)	SDILGACAKTADSDVLASVADTVHSNLQifcaLD..SANELFNSLIERL.RMMNEEQ..RLVPRPLLA
  908-  971 (86.88/57.78)	SDIVATPSHQAENNVAEEVERTLSSGTR....LDppTMNKLFRMIIPALeRGWEKEDdtRRVFATLLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.10|      27|     101|      14|      40|       3
---------------------------------------------------------------------------
   14-   40 (48.93/22.43)	PQRSVSSSSLPVQRPP....PQRSLSHQQQF
   86-  112 (28.67/10.19)	...NASSSSLPTSESPqsltPSR.IPNSDPF
  119-  142 (42.50/18.54)	PAGSASSTLMPM...P....TRRPVTSQPRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.61|      33|      93|    1293|    1329|       4
---------------------------------------------------------------------------
 1293- 1329 (56.55/45.40)	PPKmaqlSLG.MVEKLTDL.WEIVAAGPQE.RPNCHAAVL
 1389- 1424 (45.06/26.88)	PPA....TVGsLVQQVFDIaILLVDALPEElRANCARATL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.65|      12|     101|    1342|    1353|       5
---------------------------------------------------------------------------
 1342- 1353 (23.23/ 9.85)	LHSLSSEPPSAP
 1441- 1452 (25.43/11.50)	LYYLFSSPPPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.56|      18|      91|      51|      68|       7
---------------------------------------------------------------------------
   51-   68 (34.33/17.93)	APFIDLTADA...GDATPNRY
  143-  163 (28.23/13.50)	APRITATAPApakKDARPKPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.58|      28|      34|     387|     415|      12
---------------------------------------------------------------------------
  387-  415 (45.07/40.27)	ENDWKNRVTYAIrLATNLYSEQLLDRDHY
  424-  451 (50.51/39.46)	ENSLQSRIPMWL.LIAQIYWKDLLRSRKY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.46|      26|      43|     664|     689|      15
---------------------------------------------------------------------------
  664-  689 (49.07/26.42)	GGYHCAAEIDPVSGPCS.SRLLVELPL
  708-  734 (37.39/18.51)	GNYSVAEEDQDITNAIRvVKHVVGLPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.64|      17|      34|    1093|    1109|      16
---------------------------------------------------------------------------
 1093- 1109 (29.97/20.03)	LLEYSTVRNHVNGTEFP
 1128- 1144 (26.66/16.97)	LVDSSAVSNALGIKSLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP34033 with Med12 domain of Kingdom Fungi
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