<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP34031

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMVEEGNLEPVALQKSRIPGNTTQNAPNNTASTASPAEANSRNPLISPTQVAGGALPEGVSQSSAQVTDMRTTQPVPKIIYEQFIVAVISSIAFAFCSRSMAIPLNYRTMLIPPLLADANERERGSLQADPVVGTFKTYLTTTGSLVVSLTFSYCKNLATVEDVLTGDSSSPSSSVLAAPYGVFATKQNFANGDGSDRSLAQTPNTQALSVRSVPDTNDSQWKHSCLKALEYCGLNPSQFKASPWVNLLISKPTSQDADGESKRSRATVPWPGSLCFRKKPMEMSTTHRVGDTMLSGHEECHDPLGDARGWFAGASEREERISKRKAERMYAVTREVNGANPLAQNLNGQSPLTMRRPSTAAAGVMYPTPPDAIQQHIGITPSIDGAISSPNNPPPTLAVVDADMTMPTATPMADAENDAWGGQHEQKRERSDSNAMGDSDDVMNDLGEDVFGDHDVTEDDFNFFDGPDGNDLDMDMPDLQPAPTAPAPQVMPPPVLSHPEPHKAIQPQPEVKPKPKTNDSVFAKPELKHARSSLNDELNHRIKVERPDTAKRGSSPFDPATVFKRVRASLSSPTKDDFAVQPPRRKSSVFEKVEFDPKIPLINKKYEHGGAFDFSKDQSNGDSRPSAHNLSRDEYLEGQGKLKQTSKSLLGNSLIRSLTGIDASTTHASPQRLNGHDWISEESELESDGDDISSLSGGPVSPVKSSIKRTVVDDDALSQATTSRETELLDDVTDEQLAIELPKLSKTESPEMLLHRFFLDPEPLNVDVGLSNHDFVEIAQIITEQAATGRLEIGIEHKAESSVSLATMRSHELSIARNSLQLLHDAIPSNLGTPTAVRLKGLLEIQDLPLVGQPSRLQPRPIPGRDPNAEQLRANNLYQIPVPHLEVRRSETKLSVLPSSMSFWEGLGLSPSWGTKDISALCIFPGWKGMSDHVESFLSRLKSVYESLKLGTLNNLPLSGDWDDGVLPYEVDRISTSPDATVTGHGSALVESMEVLRSSLSELKSKDKNLVIYFVYSPDNPASIIEACTAFYRCFDEYSDLLAARRESPQNELVLQLVSLDMISSTTSLVVPTPAEMIKLCIETYDRCTLFLDTEFGGPTPAPAVMLEQPPPRMIDFKLTTSPSQSLMHENSCLHVGYAESLDGRWITAAWTDNRGQRQATTSYSITRSRTPDRSVSHHKAAIIAEIWATTLTMISIWKVHWRVIITKSGAMDQKEVEWWQAASTLDDKHSFTMILMSVDTNPSLQLVPPIVKIPHAATSAFYSTPVSTPQANIVSPEQTTTPATPMRDASTLAATPTAEGAAEAEADSFLIDATDQTWGAIVGHRLCNSTTLLEVRPALASGYLIKRTGIKLEDPPVVMEVNLVHTEATPRAYEPLLREMLCYFRGLGTLARARGVVDREMDVRPWHIAAAEKGVRALHLLL
Length1423
PositionKinase
OrganismFusarium oxysporum f. sp. raphani 54005
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium oxysporum species complex.
Aromaticity0.06
Grand average of hydropathy-0.381
Instability index48.35
Isoelectric point5.25
Molecular weight155355.14
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP34031
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     634.53|     218|     615|     202|     494|       1
---------------------------------------------------------------------------
  202-  456 (337.86/267.77)	TPNtqalsVRSVPDTNDSQWKHSCLKAlEYCGLNP...SQFKA.SPWVNLLISKPTSQDADGESKRSRA..TVPWPGSLCFRKK.......PMEMSTTHRVGDTMLSGHEE....CHDPlgdarGWfAGASEREERISKRkAERMYAVTREVNGAN.PLAQNL.NGQSPLTMRRPSTAaagvmyptPPDAIQQH.IGITPSID...GAIS...............SPNNPPptlAVVDADMTMPTATpmadaenDAWGGQHEQKRErSDSNAMgdsddVMNDLGEDVFGDHD..V
  508-  582 (49.48/58.84)	QPE.....VKPKPKTNDSVFAKPELKH.ARSSLNDelnHRIKVeRPDTAKRGSSPF..DPATVFKRVRA..SLSSPTKDDFAVQ.......P...........................................................................................................................................................................................................
  854- 1070 (247.19/134.41)	..................................P...SRLQP.RP.......IP.GRDPNAEQLRANNlyQIPVP.HLEVRRSetklsvlPSSMSFWEGLGLSPSWGTKDisalCIFP.....GW.KGMSDHVESFLSR.LKSVYESLKLGTLNNlPLSGDWdDGVLPYEVDRISTS........PDATVTGHgSALVESMEvlrSSLSelkskdknlviyfvySPDNPA...SIIEACTAFYRCF.......DEYSDLLAARRE.SPQNEL.....VLQLVSLDMISSTTslV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.32|      26|     632|     457|     494|       2
---------------------------------------------------------------------------
  457-  494 (39.77/37.78)	TEDDFNFFdgpdgndLDMDMPdlqpAPTaPAPQVM...PPP
 1084- 1112 (50.55/21.00)	TYDRCTLF.......LDTEFG....GPT.PAPAVMleqPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     261.92|      84|     671|     583|     669|       4
---------------------------------------------------------------------------
  583-  669 (131.87/95.15)	PRRKSSVFEKVEFD.PKIPLINKKYEHGGAFDFsKDQSNGDSRPSAHNLSRDE...YLegQGKLKQTSKSLLGNSLIRSLTGIDASTTHAS
 1255- 1342 (130.05/83.42)	PHAATSAFYSTPVStPQANIVSPEQTTTPATPM.RDASTLAATPTAEGAAEAEadsFL..IDATDQTWGAIVGHRLCNSTTLLEVRPALAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     216.65|      72|      95|     670|     744|       5
---------------------------------------------------------------------------
  670-  744 (110.33/76.60)	PQRLN......GHDWIsEESELESDGDDISSLSGGPVSPVKSSIKRTVVDDDALSQATTSreTELLDDVTDEQL....AIELPKL
  761-  842 (106.32/64.18)	PEPLNvdvglsNHDFV.EIAQIITEQAATGRLEIGIEHKAESSVSLATMRSHELSIARNS..LQLLHDAIPSNLgtptAVRLKGL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP34031 with Med13 domain of Kingdom Fungi
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