<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP34016

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTSALDFPNNCSTNVYTLNDFGEIAYIVCSVATRASHDTASWSLTPENIIDRLRRTERQFREASILAALDVEAHQLFTFYKKVDIANAKDQKALLSKFGFVLRSNTCTIAYKTAARLPDLIKPEHARLYRLFTTAVVSSIKLLPNGDSALQPVGLNIYLVERAASEGLTHIESIRKWDLYRIDLHVIPSGHVILTIVRDEQVSFVRMLELGQDSIRLQHLTQEPTAVYLAPVGRIARLIGPGVETDLGHTATNPGDVVNGVRTLDVRKELWKELLPAWLKENMNMAFDDKELPWIHVELPVQQVEGNSTAVENDSKSDDAYEDSIIWRPVFWPAKLSFVINGDKHNGTSTPSGGEDPMQFVQDWLTGPGKRPGSTIKGERTNPDAMEDDDEPLFVEDGAFGDPEQFQSFGPPAFSSSQAIYPTPPDAVMTHPTPGLSSLDAIAMTPANIARRPSEMAQPQDSEMHDFEEGPGPGGLSRFYDEDLFEEMPDDHFGQEVNGDEPNWDFFDRPGVDSRSTPMATTNRSEMFATSTGLQEGAMESRFRSVNDDDVMPLEHRSNSPGDIGPVSTIKMPEGEMENQEITPNAEKRRSFPHRSNNKESPQTSPRFQGSGAGHNGEEEAQSPKISSRRRSSFYGAIRQASTISDRDSKYTADGDYWFDPNPAAYQSKPLSTPKTIFQRPSSSPSESDSSLDSPNSSSPADYYGSDSAALPRQWIEYETQSQDTINNLDERIGGSPSQEVQDLLSLLKPGLIEPPSISDFVLRDGLHLHSTVSASELSQIAHILVEQVSQTTLNIPDLQVDQSAEGLEEHFDVSIDLSGINTSTQPASVSQLVNLEADSTGPKSQGKVVKLPPSQVCVQRADQPLVAAPSILDFWDTLNLQPGNGAKAATAFCVHPNARNIADGCLNLLQRMTDTYNSCSLGLHSTGRLSGVTDDGLIVWDRKSTSRSDLHQTCRKVGSALATASNIKGTAIIYMISQDRSAASYLEACQAFCSLFESFRQALGDREDVFDIALQVIPQDFVASPDTLVIPPQSAYIRLAIEVYNRLPPPDLTEPQAASGSAIVLAKVDTSVHFRLSPTFTSPLSYNGPCLHLAYSASVDDRWICATWTDELGQVALMMSYCTRVCNASHKRPKSEIFREMWEISHDIMGRVHSSWRLAVVKQGYYESADLLDWKQIIDNPSNSQRQCVAMLLSVQLHPELKVFPPPAQAKTGQVGLQNTYGTPASTPQASITSPDQLIAATPTPGGSSIVNAPTPSEPGFDPNIESDLTLVDPTEESWGVILPYGVNQTTSMVGLQPALVTGLLLKRKGSKIEDGCTAIEVSLISISAPTTESSSENPEEVLEDLLTQYRGLVTLAATRGCIDPLRESVPWHIATSVRGSRVLGDVL
Length1389
PositionKinase
OrganismCapronia coronata CBS 617.96
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Capronia.
Aromaticity0.07
Grand average of hydropathy-0.372
Instability index52.94
Isoelectric point4.81
Molecular weight152174.29
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP34016
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     190.81|      39|      39|     554|     592|       1
---------------------------------------------------------------------------
  446-  479 (36.08/14.94)	...........PANIArrP..SEMAQPQDSEMHDFEEGPGPGGLSR..F
  490-  528 (47.02/21.69)	DDHFGQ...EvNGDEP..N..WDFFDRP.G..VDSRSTPMATTNRSemF
  554-  592 (68.78/35.08)	LEHRSN...S.PGDIG..P..VSTIKMPEGEMENQEITPNAEKRRS..F
  594-  634 (38.93/16.70)	..HRSNnkeS.P.QTS..PrfQGSGAGHNGEEEAQSPKISSRRRSS..F
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     377.71|     125|     810|     288|     439|       2
---------------------------------------------------------------------------
  288-  439 (205.02/149.51)	DDkelPwihvelpvqqvegnstaveNDSKSDDAY.EDSIIWrPVFWpakLSF.VINGDKHNGTSTPSGGeDPMQFVQDWLT..GP...............GKRPGSTIKGERTNPDA...MEDDDE.....P.LFVEDGAFGDPEQFQ.SFGPPAFSSSQAIYPTPPDAVMTHPTPGLSSL
  693-  830 (133.40/65.84)	DS...P...................NSSSPADYYgSDSAAL.PRQW...IEYeTQSQDTINNLDERIGG.SPSQEVQDLLSllKPglieppsisdfvlrdGLHLHSTVSASELSQIAhilVEQVSQttlniPdLQVDQSAEGLEEHFDvSIDLSGINTS.....TQPASV...........
 1208- 1251 (39.29/ 8.06)	...................................................................................................................................P.AQAKTGQVGLQNTY....GTPA.STPQASITSPDQLIAATPTPGGSSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     129.90|      47|     397|     850|     906|       3
---------------------------------------------------------------------------
  851-  906 (76.75/64.71)	KLPPSQVcvqraDQPLVAAPS..ILDFWDT...LNLQPGngakAATAFCVHPNARNIADGC
 1047- 1079 (28.83/ 7.79)	RLPPPDL.....TEPQAASGSaiVLAKVDTsvhFRLSP.......................
 1297- 1318 (24.33/ 7.18)	...................................LQPA....LVTGLLLKRKGSKIEDGC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.18|      35|      36|     920|     955|       4
---------------------------------------------------------------------------
  921-  955 (60.89/50.47)	SLG..LHSTGRLSGVTDDGLIVWDRKSTSRSDLHQT.C
  957-  994 (49.28/32.62)	KVGsaLATASNIKGTAIIYMISQDRSAASYLEACQAfC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP34016 with Med13 domain of Kingdom Fungi
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