<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP34002

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNGDRPTANGEPLSNGIQQDAATTTPSAGQIKQEGEAAGLSASGGEGSSHANGDINASQLPEGDIGPNVANGVEQAPSEILHLIPKDNYLPIAALITRASQSCWNGLSDLVEELASIQVPEQSAEHTKLLPNNLPNNQTRANLDKKERLLQFANYQKADFVKLLVLLQWSKSVDDVSKTISINFWLMKRRQAYWDAIASLATLKQESAGFQIPNPDLKGGAEVLATGRMRKFSTLDYIPQKDLSDKQILQLLRTLNRSLSVKLTLADDLPPQLRRYRIHDGRVTFIVPHEFEVDLSILDDSPDAQFRMVDFRFCFSPLPHIPDNLRSEIELCANTNIDRDGLQGCYLFLHELALSYKLAEFHRQALELARGQWVGNIRVEMIRRNLIIQYWPERQIGKSWIEIGIASGTAKKDGRSQDLVPFLEIKCMRQGKRVDSPQVHLDESRLSLEEILHQVIAQHSTQILDSIYDKLALTPLFAKAELSLDQNISHQNPEECSLTMQLSRPSRIQIKIEPVTGLLLISPVSERSERLQYEINRIHGVAEEIVSKLLNFRCSIREASVFAGTTGTSWEALRAFKFNQAEIKALFGDPVVRINLFRQAPWGLGYSLAVTHSQHGDHWWLLQQLRPSGPHLQPRFQVIRSQRIEISEELSAAYFERLAEYATGLICLRRNADYLEERKEKVSLAPFPAFGRKYELPELSFDLDLSRPALRSPSGSTTQTVPAKMSKTSWTSPDILKSVKFRFGGLDRATNSITAIGQLQNRASSAALKHIDASILEPDVTMSSEDGSVTIRVKTSITEPAIPEIVAKAMDLEKIVSTVEQIHHLPGLQLKNLSNSAFTITYHTEPPKEYSLGMTFTRGSEVPRLEFLPLCDNPHTLLSAQYSKHFEAGRAPFATQVRDFLTSLKVTLPLLTFLRDIQGSHGLDIKDSQVPSSDGQRSAMRVHILPRTTTAFAIQYFTAAADVPRDVGPGSHPHLLARLEILPHLTVSEKPMWLVRAALEDFQSYSKPSYSSPALRNKLREEVFARADNGGKWLALDTAAVCPADQPETMLRAIHDLLSKWVTEGTASTSKGDKQIKGTTTSKQAGRQDNNASNLNQQRSSNGNDNGNSNVKPVAKAPGPAKMQAHGANASPNGGIKTQWPPPNASMNMGGRMAAAGKGNANANANARRNNEVITLD
Length1177
PositionTail
OrganismCapronia epimyces CBS 606.96
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Capronia.
Aromaticity0.06
Grand average of hydropathy-0.379
Instability index47.30
Isoelectric point7.67
Molecular weight130387.39
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP34002
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.97|      16|      17|     136|     152|       1
---------------------------------------------------------------------------
  136-  152 (23.22/16.59)	NNQtRANLDKKERLLQF
  154-  169 (28.75/16.15)	NYQ.KADFVKLLVLLQW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.18|      27|      29|     261|     289|       2
---------------------------------------------------------------------------
  261-  289 (45.91/37.68)	VKLTLADDLPPQlrRYRIHDGRVTF.IVPH
  293-  320 (48.27/32.73)	VDLSILDDSPDA..QFRMVDFRFCFsPLPH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.34|      12|      15|     892|     903|       3
---------------------------------------------------------------------------
  892-  903 (21.83/13.31)	PFATQVRDFLTS
  909-  920 (21.51/13.02)	PLLTFLRDIQGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.87|      15|      15|    1134|    1148|       4
---------------------------------------------------------------------------
 1134- 1148 (30.61/18.19)	GGIKTQWPPPNASMN
 1150- 1164 (26.26/14.50)	GGRMAAAGKGNANAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.99|      18|      35|     931|     949|       5
---------------------------------------------------------------------------
  931-  949 (28.78/21.28)	PSSDGQRSAmRVHILPRTT
  969-  986 (34.22/20.30)	PGSHPHLLA.RLEILPHLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.34|      10|      16|      44|      53|       6
---------------------------------------------------------------------------
   44-   53 (19.62/10.50)	GGEGSSHANG
   63-   72 (19.72/10.59)	GDIGPNVANG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.92|      13|      15|     838|     850|       7
---------------------------------------------------------------------------
  838-  850 (25.87/14.64)	FTITYHTEPPK.EY
  854-  867 (20.05/ 9.79)	MTFTRGSEVPRlEF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.58|      29|     407|     180|     229|       8
---------------------------------------------------------------------------
  180-  212 (47.29/29.65)	ISINFWlmkrRQAYWDAIASLA.TLKQESAGFQI
  592-  621 (52.87/24.15)	VRINLF....RQAPWGLGYSLAvTHSQHGDHWWL
  653-  663 ( 3.42/15.39)	............AYFERLAEYA.T..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.61|      20|     461|     552|     573|       9
---------------------------------------------------------------------------
  553-  573 (33.36/26.42)	RCSIREaSVFA.GTTGTSWEAL
 1016- 1036 (32.25/15.20)	RNKLRE.EVFArADNGGKWLAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.62|      27|      33|    1072|    1102|      10
---------------------------------------------------------------------------
 1072- 1102 (35.71/35.51)	GDKQIKgtTTSKQAGRQDNNASNLNQqrSSN
 1107- 1133 (47.92/31.39)	GNSNVK..PVAKAPGPAKMQAHGANA..SPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.48|      11|      19|     770|     780|      12
---------------------------------------------------------------------------
  770-  780 (19.17/11.76)	HIDASILEPDV
  792-  802 (18.31/10.90)	RVKTSITEPAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.47|      19|     461|     221|     244|      13
---------------------------------------------------------------------------
  213-  233 (25.18/21.29)	PNPDLkGgAEVLATGRM..RKFS
  239-  260 (22.29/ 6.15)	PQKDL.SdKQILQLLRTlnRSLS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP34002 with Med14 domain of Kingdom Fungi
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