<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33994

Description Uncharacterized protein
SequenceMTLNPPAEPRPPPPRRPPEVHRPSFDRSSTKVIPPHDRRVLGLQRHIVQPGDDRPAKRRKVEGDGFTGQTSSTGDGSPTSQSPELAPTTKGYNLRLLKPSTLDLGGPRRDDQTEEAKCVDAELPDLPTRPWHHAQSSKVTEDPKPTHRLRVKIPVPTTPDSLQIPSSAPYIVPKKPAGFFPWTGKHPEDVLNDVNVKQGFFDKPPNPLDKELNTARVPLYNALKHKSGVENLSILFSLILDQKNQHGLISSASTFRPPPRVTLTEAKRKSWIADLANAEVPLRRLSRTIPQGIRGQVLLDLCLRSCVPLNRAIWFVKCVCANEIRTLKRKGTTPAVAVGAESKWLREWTVSVEQFIEAHLGRAKQQDWRAEMQYALRLTTRLYMENLLDRDHYLDWIVRSFHTTDLPHVPFWLMVIHILKDDLSHYRRRGKRLAEVLIEKFRLASRYTDQSTSSVRQKLYHMIRWLLLSRPMNFVMPETWPEVVESVRTCLDNSVQQERYILDQLNRVNARAMGHNKEAFTAQRTAHQVIVEILDAAQAPYDLPRLAENLDAACADSPLLISTCLEWACTRFRQSKARPYLFARLARRWQRAGHDVDNIILNYFSSCRNGDTTAECNALQHLAAHLSRSGLFPLSKYMQWLMVRGLPKRGEMETLSHSIRRGAGPRTLGVDAASSQLLLHVSLHNVEPHVINLRSSILRGCGFDPEVEDDIFQDSIHFIEQKLRNLGYRPPSSHSSEREPAFGFLPWTIKSRLAMWLRRSVAETARVSMGAPGAPIGVPLLDSRIFNVEQFAFICNILECMEDVAVLADVIGILCGSQDDHLVASLVATIQFHADTFSAIGALEVLQRRICQIYMSWRNIRPTMPLLTSTLLDLCTTYPVTAPSTRLLQQDFVRGDRGRAVAACSPYSDGIAESLQQAGATFVEDFEAILQSEPNMNEQTMNGLFAVLADRIEKQQKFDHDTETVVSFCQLLSRLRLCRKGQGDFLLHRWITRLVPSVDAKYGSLLLQSLIGTGCMTFAGVFGADAVSNAKLRRSSAVRLLLEHINAPPQNLLADLIFYRTRSRWFEYVRREARAALELLCDLGLESALHSMQEILLACLVKDDTIRSSPMSDSAQQWLLKALDRLLSRQGDLSGSGDIKTLVSSINFFSHQFVQLSFWLTSRSRLENGVSPDEDELVRVLSEVIEQMLQNPAGNKEATMWFAKLLEAVEVDVGNRLRHQVENEFLDALPKFQFNKGTSPVTAMFSSDVHHLSSIMERAYLLCTESTSPTPGFMVQLIDKLSQHLKALGGNPSAVSVPASTGLSGSPMNMTHPQTMSVTSSPAATNSEGGHGVTPGLILGYLSHILEMICLQRRALATAGHTGTNLKQAQTEEVQLLVRLALIATHPAMTSAPTSLLSKEDQQKAKEVRDFTLDVIATIVDDVSDEARMMSAKFLKDKLQDGRMKYLFGSINVMGSAQVRDLGQGLQMVKEGKGVLGDWRPRVWEVLDNGSGKESEAPLGLGLFGARHTT
Length1510
PositionKinase
OrganismCapronia coronata CBS 617.96
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Capronia.
Aromaticity0.07
Grand average of hydropathy-0.264
Instability index57.21
Isoelectric point8.69
Molecular weight168935.75
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33994
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     239.10|      71|     243|     343|     430|       1
---------------------------------------------------------------------------
  343-  430 (115.94/110.08)	KWLREWTvSVEQFIEAHLGRAKQQDWRAEMQYALRLTTRLYMENLLDRDHYLDWivrsfhttdlphvpfwLMVIHILK....DDLSHYRRRG
  588-  662 (123.16/79.54)	RWQRAGH.DVDNIILNYFSSCRNGDTTAECNALQHLAAHLSRSGLFPLSKYMQW................LMVRGLPKrgemETLSHSIRRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     543.07|     188|     273|     757|     965|       2
---------------------------------------------------------------------------
  757-  965 (274.68/267.84)	LRRSVAetARVSMGAPGAPigvP..LLDSRIF...NVEQFAFICNilECMEDVAVLADvIGI..LCGSQDDHLVASLVA..TIQFHADTFSA....IGALEVLQRRICQIYMS..WRNIRPTMPLLTSTLLDLctTYPVTAPStRlLQQDfVRGDRGRAVAAcspYSDGIAESLQQ.AG...AT..FVEDFEAI.LQSEPNMNEQTMNGLFavlaDRIEKQQkFDHDTETV
 1032- 1241 (268.39/193.94)	LRRSSA..VRLLLEHINAP...PqnLLADLIFyrtRSRWFEYVRR..EARAALELLCD.LGLesALHSMQEILLACLVKddTIRSSPMSDSAqqwlLKALDRLLSRQGDLSGSgdIKTLVSSINFFSHQFVQL..SFWLTSRS.R.LENG.VSPDEDELVRV...LSEVIEQMLQNpAGnkeATmwFAKLLEAVeVDVGNRLRHQVENEFL....DALPKFQ.FNKGTSPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.86|      21|     563|     165|     185|       3
---------------------------------------------------------------------------
  165-  185 (44.27/27.35)	PSSAPYIVPKKPA.GFFPWTGK
  187-  203 (29.28/15.44)	PEDVLNDVNVK.Q.GFF...DK
  731-  750 (33.31/18.64)	PSS..HSSEREPAfGFLPWTIK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.18|      16|      42|     216|     232|       4
---------------------------------------------------------------------------
  216-  232 (24.84/18.27)	RVPLYNAlKHKSGVENL
  260-  275 (28.34/16.29)	RVTLTEA.KRKSWIADL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.78|      11|      42|       6|      16|       5
---------------------------------------------------------------------------
    6-   16 (24.28/11.74)	PAEPRPPPPRR
   50-   60 (20.50/ 8.65)	PGDDRPAKRRK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33994 with Med12 domain of Kingdom Fungi
Unable to open file!