<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33993

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTVTKWTTLTRQCLLRRMSVSEFGDLVRSSGEIDGKKLFSALVECRASFCVAGDPLISLYLDHVGSSGLLSISDALLVLISKWNAAGTPWSQTPPECYGQTLQDLTMLVVSPKYKMTASEARIALLISSRWLSSVVRALPHELADSSSTGYTHVIEALGFLVASIAATDGGLEALSPADSQKADAQAGPGPGPGPEPRESLRHAFESCLPLYSTLSAQLMERLNTVLKHISLLDSGNPQEGTMSAQSSAMQALQFQVSIPESQMVASKAATIMYLESLLLTGATVDDSTAVNFICSRHQNDYHSAFTDLLRASFHILKTQALHPPRRLCYQQCQLFVQNKLPILLSMISASSFNSFHTEQAITETWAQVAPLLSDQVLAMTGSRFLHTCSLHHLMTVQAATQLMGSDDLPNSLSRGLYAKDDLVSQVRTSHMKGPKLVDELVRGDGSAPFISQSLVEIMHSYCHSKETQYLKELANMILRKPAAINCIALFIRPAYWLGPLCTLLDDWRWDEIHGEAQPVYDEFGAVFLLVLVTKTRLGLSNSDIGVRKKDGFLAQYLDQENPEESLDGLSEEKKTHLGNWINALYLAEGLSDELFTSCSPHDFYLLIPALLQQSVAAHHQGKLTQESLKAGLDYLLEPFLLPSLIPALNCIGSLLRENPTSAGIVLEALVKSPESADSQAIHQTILATCAPQLETNIRAFQPGNFDSVLKLLEQCPESSFSSAEHQEVQLQDGQLLHGLQSHLVALIASHGVLDVEKQASSPNVPAMVRRAVEVQGVEAALRALVGVLLQLSDSPDFLFSLDAVATLVTMTGNELRDILRVQYGTLGTLLKKGETLSAEAVVRLHRLVEAYTNLLAVHDMGLDSFSFAQQLTNIDTTNPNLDGNATASRGIDLQTETTQTDGIDQVLDEVAAMSNMDSNDADMNFDALYGLQSADMDLNDLDLDMF
Length947
PositionTail
OrganismCapronia epimyces CBS 606.96
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Capronia.
Aromaticity0.06
Grand average of hydropathy0.008
Instability index43.64
Isoelectric point4.93
Molecular weight103240.36
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33993
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     134.89|      35|      35|     758|     792|       1
---------------------------------------------------------------------------
  714-  757 (41.60/26.56)	EQCPESS....FSSAEHQEVQLQdgqllhGLQ..SHLVALIashGVLDVE
  758-  792 (54.47/37.28)	KQASSPN....VPAMVRRAVEVQ......GVE..AALRALV...GVLLQL
  793-  830 (38.83/24.25)	SD..SPDflfsLDA.VATLVTMT......GNElrDILRVQY...GTLGTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.59|      33|      36|      20|      55|       2
---------------------------------------------------------------------------
   20-   55 (52.46/37.30)	VSEFGDLVRSSGEIdgkKLFSALVECRASFCVAGDP
   57-   89 (56.13/32.21)	ISLYLDHVGSSGLL...SISDALLVLISKWNAAGTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.52|      50|      62|     833|     883|       4
---------------------------------------------------------------------------
  833-  883 (77.79/58.67)	KGETLSAEAVVRLHRLVEAYTNLLAVH.DMGLDSFsFAQQLTNIDTTNPNLD
  895-  945 (79.74/55.43)	QTETTQTDGIDQVLDEVAAMSNMDSNDaDMNFDAL.YGLQSADMDLNDLDLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.39|      39|      63|     558|     598|       5
---------------------------------------------------------------------------
  558-  598 (63.60/40.23)	LDQENPEESLDGLSEekKTHLGNWINALYLAEGLSDELFTS
  624-  662 (67.79/37.71)	LTQESLKAGLDYLLE..PFLLPSLIPALNCIGSLLRENPTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.40|      39|      62|     148|     187|       6
---------------------------------------------------------------------------
  144-  182 (63.56/42.18)	ADS.S.........................STGYTHVIEALGFLVASIAATDGGLEALSPADSQK
  183-  247 (40.84/29.52)	ADAqAgpgpgpgpepreslrhafesclplySTLSAQLMERLNTVLKHISLLDSGNPQEGTMSAQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.68|      21|      62|     371|     391|       7
---------------------------------------------------------------------------
  342-  361 (31.84/16.81)	PILLSMISASSFNSF.HTEQA
  371-  391 (35.96/19.90)	PLLSDQVLAMTGSRFLHTCSL
  402-  418 (21.88/ 9.32)	QLMGSDDLPNSLSRGLY....
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33993 with Med5 domain of Kingdom Fungi
Unable to open file!