<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33991

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMERLSQMDHSNDFASEAFFDQNSLDQIQQIDPTTDLGSVANVALPPNLAVAEQLNRRWSSGCLERIAWSRHGNLASISDDASTVNLECLRYSHDAKAWQLNERHTLATIFEDAVSLAWSSTGGELAVVDIKGRIWVYHISGVAINRLVLNRRGDLDEERETSQPIGMTWLNQDRQERPRNFVALATKVDSRWIHTNARTRPPGPYWHRAIVVVHRNGLLTLCFQRGDGQYSKVTKHLSPSDNTLYSHASFAPTLEGKMLVALHSFKNFISVCLISIDWTEVRQAVEGLPIMTVEYVSSKVSSRPSGSSTLGDVYDPDSWRLTHLEVAQSPDVERAVQTPPTILSVSSGINREVSITDHGFLVSSMIKRWAVISVERKLHPRFDELPSKGSSKIGSPSVYTLQPRPEKEEQVITTVHHLEGSLALVVTTQEGRTDFLNSEDLSPVSYAASVTETSSMSQSGFVFPFVPNVTCPTFSPSACVRADLTPDGKTQLVTMEHPLGQGQAQQPLDPNIDVAIAALNLTFARACWTNATFDDVLMCASHSIPTAITPAIVSGLYRSLFRDNEFVNEKMQGSELERMFHKPYMGRVMAYHACLTANCGQLPSIAPTEGRIGWSLSAQWAWIANNIRHTATVLFMNLRDVQNTNLVMTQDFTDMLCSNLRWGLSVIRFIISTILEVGDRETNPEMFDDKDPGRLGDINGDGSQGLVALLLNIHCSRQFLVAFVRAVRAYAKNTEPKSQHHVQVLQCIQQQTTNKGISFQAIEALLEYRWSVHGDIEGDIPGTATRQLDMMATGIVHEAYQGTIKLLLNKLVNSPVGLRAKMLIDRLKLFTELVDIEYVFLNHDILGRRDGEPKQTQIVYDIHRKKPISKSALDPNGTGVLMVRRCIRCGSFSEDINASPRDWPRQVASLLTKCVCDGHWALEPWDRNSN
Length930
PositionTail
OrganismCapronia epimyces CBS 606.96
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Capronia.
Aromaticity0.07
Grand average of hydropathy-0.236
Instability index42.02
Isoelectric point6.14
Molecular weight103777.58
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33991
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.98|      23|     576|     170|     203|       1
---------------------------------------------------------------------------
  170-  192 (41.45/46.32)	LNQDRQERPRNFVALATK..VDSRW
  896-  920 (40.53/19.32)	INASPRDWPRQVASLLTKcvCDGHW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.65|      27|     450|      36|      62|       2
---------------------------------------------------------------------------
   36-   62 (47.91/35.30)	LGSVANVALPPNL........AVAEQLNRRWS...SGC
   74-  109 (30.10/19.04)	LASISDDASTVNLeclryshdAKAWQLNERHT..lATI
  113-  141 (30.64/19.54)	AVSLAWSSTGGEL........AVVDIKGRIWVyhiSG.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     193.77|      63|     290|     304|     376|       3
---------------------------------------------------------------------------
  304-  376 (88.27/90.67)	PSGSSTLGDVydpdSWRLThlevAQSPDVERAVQTPPTILSVS.SGINREVSITDHGF..LVSSMIkRWAvISVER
  603-  668 (105.50/73.42)	PSIAPTEGRI....GWSLS....AQWAWIANNIRHTATVLFMNlRDVQNTNLVMTQDFtdMLCSNL.RWG.LSVIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.68|      47|     364|     481|     535|       4
---------------------------------------------------------------------------
  481-  535 (69.21/72.28)	RADLTPDgKTQLVTMEHpLGQGQAQQPLDPNidvaiaALNLTFARACWTNATFDD
  848-  894 (84.48/60.46)	RRDGEPK.QTQIVYDIH.RKKPISKSALDPN......GTGVLMVRRCIRCGSFSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.24|      15|      94|     698|     712|       6
---------------------------------------------------------------------------
  698-  712 (25.86/15.22)	INGDGSQGLVALLLN
  795-  809 (26.37/15.64)	IVHEAYQGTIKLLLN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33991 with Med16 domain of Kingdom Fungi
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