<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33982

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMTESKTFTVPIPPEGSSTSQDLPIQIQKIIAQKGHFRHVAERSLLAEIHGKALASEENGPRSEADGQTNEIEAPQELRERLWKSREEMLERLSYAQNEILCALDFVSLLISKQSIPAQSSMSPALKEAVPAGTLAAQTLKLKPLPSSVRQRLASTSQGWRLESFRSASNKLSAASSRLKADTERETEYWAQIADLTASGWAVSRLPRDSKAIGVHFGFPESAPRFRDRGFALLRQANDGAVILDKHLLERKRKWLGVYVNRHNVRTGFFCAQKPTTSRSRSISEQLTEMRDSLFEEELFYEICREARIVANQGVSTRAQAVDLEVGSGYHVSLVFAEDHDLETCANADDNTIAEFVAVSLRLLLNAAHQQNLIRRSQKPPPMTLKPRPLPEYPLVRPVLTHLRHKAEATAFWKSCQTLIRPFLQAELPVSIALEKSTSHVFGSLNMDASSTILSEMMLPAKAGCKISLTGGRSMQVGLATFLGPPLYGSRYETSAVDFGFSHIPSLRHETEETTVSFIRRVLLLDLVVHVESMIKEFNNVNKSERGTFREWRLAQPHNGEFTLCDSGEAVEKFKVAVLPESISIKWSNLGKGSATKYLIWTWTASKCTKADGTEVEPETDMTFGQAVDRILKGVI
Length635
PositionHead
OrganismCapronia epimyces CBS 606.96
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Capronia.
Aromaticity0.07
Grand average of hydropathy-0.311
Instability index47.05
Isoelectric point8.29
Molecular weight70754.81
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33982
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.45|      39|      96|      53|      96|       1
---------------------------------------------------------------------------
   53-   96 (58.50/45.65)	LASEENGPRSEA.DGQTNEIEAPQelrERLWKSREEMLERlsYAQ
  152-  191 (61.95/35.60)	LASTSQGWRLESfRSASNKLSAAS...SRLKADTERETEY..WAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.19|      25|     103|     402|     431|       3
---------------------------------------------------------------------------
  402-  431 (36.62/32.88)	LRHKAEATAFwkscqTLIRPFLQAELPVSI
  506-  530 (41.56/23.52)	LRHETEETTV.....SFIRRVLLLDLVVHV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.90|      15|      38|     292|     306|       4
---------------------------------------------------------------------------
  292-  306 (27.67/18.87)	SL.FEEELFYEICREA
  332-  347 (23.23/14.73)	SLvFAEDHDLETCANA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33982 with Med17 domain of Kingdom Fungi
Unable to open file!