<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33975

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDQDQADDFASESFFDQNSLQQQIQQIEATADLNAVSNVALPPNPAVVDKLSRRWYCGCLERIAWSRHGHLASISDDGSTVYLECIRYNYESKSWGLHERHSLTTLFEDAASLAWSPNGGELAVVDVKGRIWVYHNSPLAINRLILARQGALDDGDEYSQPVGMTWLNQDRQERPRNVVINAFKGDDRWQHTNARAKPLGPYWHRAVAIVHRNGLFTLCFQRGDGQYSKVTKQLSPPDDMLYSHASFAPTLEGKMLITLHSFKKVISVYFLSIDWNEVKQAVEGLPVLTVESISNHVSSQPSGSPTLPDSYDPDSWLLSHLEVVRTSDVEKAVQMPPTILAICTGVNRTVNIPDAGFLVSSMIKRWAVNPVQQKLHPLFDALPSIGPGVTASKSTYSLQRLPDKEEQVITTIHHVDGVQAIVVTTQENRIDFLSSEDLSPMSYASLAQETTSMSQSGFAFPYAEFILTPAFSPNTCVRADLAPDGKTQLFSMEYQLGQPQSLQPLDPNIDVAIASLNLTFARACWSNATIDDILMCVSQSVPTELIPTVISTVYRTLFRDSDFVHERTEGSELEKVIHKTVMGRVLSYHASLAANCPQLPSIASTDRRNGCWSLSAQWAWLVNNIRQTATLLFMAMRDVQNIQLVMSQDLTDLLCSNLRWGLSLMRFIISTILEVGDRETNPEMFDEKDPGRAGDSLGDGSQGLVALLLNCHTSRIFLIAFVRAVRAYAKNTEPKSNHHLQVLQCIQQQTSGKGLSFQAMEALLEYRWSAVGDVDRDMAATAVRQLEMMATGIVHQSYQGTVKVLLNTLFNSAQGLRAKMLIDRVKLFIDHVDLEYIFLNHDILGRQSTDGDSGKKEVIYDVHRKRPISKGVAEPNGPGQLMVRKCLRCGSYSEDVNVPPREWPRQVAMLLMRCVCDGSWVLMPWDKVHK
Length930
PositionTail
OrganismCladophialophora psammophila CBS 110553
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Cladophialophora.
Aromaticity0.08
Grand average of hydropathy-0.203
Instability index44.05
Isoelectric point5.87
Molecular weight103951.10
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33975
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     278.99|      87|     295|     454|     546|       1
---------------------------------------------------------------------------
  454-  546 (133.35/100.35)	SQSGFAFPYAEFILTPAFSPNTCVRADLAPDGKTQLFSMEYQLGQpQSLQpldPNIDVAIASLnLTFARACWSNATIDDILMCVSQsVPTELI
  751-  837 (145.64/88.28)	SGKGLSFQAMEALLEYRWSAVGDVDRDMAATAVRQLEMMATGIVH.QSYQ...GTVKVLLNTL.FNSAQGLRAKMLIDRVKLFIDH.VDLEYI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     217.17|      65|     293|     558|     638|       2
---------------------------------------------------------------------------
  107-  172 (112.95/71.68)	FEDAASLAWSPNGGELAVV...DVKGRIWVYHNSpLAINRLILARQGALDDGDE.YSQPVGMTWL.NQDRQ
  558-  627 (104.22/104.61)	FRDSDFVHERTEGSELEKVihkTVMGRVLSYHAS.LAANCPQLPSIASTDRRNGcWSLSAQWAWLvNNIRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.86|      30|     131|     282|     311|       4
---------------------------------------------------------------------------
  282-  311 (50.38/31.83)	VEGLPVL.TVESISNHVSSQPS..GSPTLPDSY
  377-  405 (24.89/11.94)	....PLFdALPSIGPGVTASKStySLQRLPDKE
  415-  443 (43.58/26.52)	VDGVQAI.VVTTQENRIDFLSS..EDLS.PMSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.46|      12|     562|     325|     337|      11
---------------------------------------------------------------------------
  325-  336 (20.04/12.46)	RTSDVEKAVQMP
  342-  353 (21.42/ 7.81)	ICTGVNRTVNIP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33975 with Med16 domain of Kingdom Fungi
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