<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33973

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTTTLEFPSNCSTNVYTLNDFGEIAYIVCTVATPPTQDPSAFIVTAENTLTRLRKTERQFREASILAALDVEARQLFTFYKKVDITAPKDQKTLLLKFGYVLRSNTCTIAYKTAARLPDLLKPEHSRLYRLFISAIVSSIKFLPNGETALQPLGRNMYLVEQTPSGTKIDHLDKTKKWILYRIDLQVVPSGHIILTIAKDGAFSFFRIQECVTKLKWNGTKNSDSIAIYLAPVGRIARLSRSNILNKTNLIGTSGKQNNGESLLSDARREAWQELLPSWLKEHTDTSIEEMEGGWIEIEVPIEEVDQVSNDSQQDLTTSDIVNCDSITWRTIFWPAGLCFVFSDEDPIVEEDTDVGQDPMQFVQDWILGTGGGTSNAEGGRQSVMDEDDEPLFADEGAFDDPVHFHPFGPPAFGSSQPIYPTPPDVGMIHPTPGFPSVDGMALTPANFPRGPAERSQPPDEDMADFEDAHTSSGLQGLYDEDLFEENPDDNLCAETNGDEPNWDFFDGPGINPKPARSASHGRNEESVTRSDTQPAMAEANNDTDGQGAASQNPAIAKSENLHFNAAPKIPASTKSPQTRDQIEQPDSLLQAKSRLTPQPPSKRGPPLWKPEFATDPTISVVSGRRSSLYDGLRSLPSVSTHDSRYGADGDYWFDPTLVLSNVKSYAKPNPLFQKPVSSPSDSDSLMTSSSNSPDPASQQNTAHVPFRQWTEYHHPSPTAANRQSEIDKKSIYQDVQQILGFLKLGLIEHPTLSDFRLDEPDSRKIPPTSPQKFLQIANVLVEQMSQTSLLPQGEYQSEMQTLFQDQMDVNVDLSGIKTSATPSTVFQLINLKADHNNGRVQGKVIRIQPDQIRVRRTERPLTASISILNFWDTLNLQPESGLKDVTAFCIHPGLANVTEGCLSLLQRLAETYNSCSLGAFTIGQLPGLTDTGLISWVPNDVGERNLLQTCKLVGTTLATASNIKGTVLVCMIGRSQSATAYLETCIAFFSLFESFTEARTDIQGVSDIALQVVPQNFVANAEALVIPSQTAYIRLAIEVYNRLPPPNFPASPATCSSAVVLSKSENSVHLQMTPTYGSPLEKNGPCLHLAYSVSLDNRWITAAWTDELGRVALTMSYCLRVRQSGKSRPLHDIFREMWDVSQDLMSKVRGPWRLAIVRHGYYEQSELLDWHQIFDNSPSLQKRCLLVLLSVQVAPELEIFLPPNHGKTAQTGTQNLYGTPASTPQGSMTSPEQTVPATPTPGGSSFMNAPTPSDPGFDLNAESDLTLLDPSEESCAVILPYGVNQTRSLIELRPSQVTGYLMKRKGAKWEGGYNMIEFSLITSTLQISNTSSETSPDELLEDLIKQYRGLVTLGATRGCVDPNRECLPWHIATAIRGARLLGQVM
Length1386
PositionKinase
OrganismCladophialophora psammophila CBS 110553
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Cladophialophora.
Aromaticity0.08
Grand average of hydropathy-0.364
Instability index50.64
Isoelectric point4.98
Molecular weight152831.07
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33973
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.81|      29|      32|     888|     918|       1
---------------------------------------------------------------------------
  888-  918 (49.28/37.23)	AFCIH..PGLANVteGCLSLLQRLAETYN...SCSL
  920-  953 (44.53/27.17)	AFTIGqlPGLTDT..GLISWVPNDVGERNllqTCKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.75|      15|      37|     612|     627|       4
---------------------------------------------------------------------------
  612-  627 (22.06/15.39)	EFATDPTIsVVSGRRS
  651-  665 (28.69/15.86)	DYWFDPTL.VLSNVKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.41|      26|      31|     723|     750|       5
---------------------------------------------------------------------------
  723-  750 (39.73/37.43)	RQSEIDKKSIYQDVQQilGFLKLG..LIEH
  757-  784 (40.68/30.55)	RLDEPDSRKIPPTSPQ..KFLQIAnvLVEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     202.90|      58|      71|     333|     395|       6
---------------------------------------------------------------------------
  333-  395 (100.21/66.65)	FWPAGlCFVFSDEDPIVEEDTDVGQ.DPMQ.FVQ.DWILGTGGGTSNAEGGRQSVMDEDdeplFAD
  405-  465 (102.69/56.11)	FHPFG.PPAFGSSQPIYPTPPDVGMiHPTPgFPSvDGMALTPANFPRGPAERSQPPDED....MAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     186.88|      57|     204|    1045|    1172|       7
---------------------------------------------------------------------------
  821-  882 (92.48/31.36)	ATPSTVFQLINLKADHNNGRVQgkvirIQPDQIRVRRTERP...LTASISILNFWDTLNLQPESG
 1051- 1110 (94.41/158.92)	ASPATCSSAVVLSKSENSVHLQ.....MTPTYGSPLEKNGPclhLAYSVSLDNRWITAAWTDELG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.92|      45|    1017|     274|     320|       8
---------------------------------------------------------------------------
  274-  320 (75.27/62.60)	ELLPSWLKEH.TDTSIEEMEGGWIEIEVP.IEEVDQVSNDSQQdlTTSD
 1292- 1338 (71.66/52.40)	ELRPSQVTGYlMKRKGAKWEGGYNMIEFSlITSTLQISNTSSE..TSPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.30|      14|     823|     183|     203|      10
---------------------------------------------------------------------------
  165-  178 (25.04/21.61)	SGTKIDHLDKTKKW
  190-  203 (23.26/ 6.88)	SGHIILTIAKDGAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.09|      19|      22|     524|     542|      11
---------------------------------------------------------------------------
  494-  507 (19.59/ 8.26)	.....AETNG.DEPNWDFFD
  513-  532 (24.65/12.37)	PKPARSASHGrNEESVTRSD
  533-  551 (29.85/16.59)	TQPAMAEANN.DTDGQGAAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.88|      41|     570|     667|     707|      12
---------------------------------------------------------------------------
  667-  707 (72.83/34.55)	AKPNPLFQKPVSSPSDSDSLMTSSSNSP....DPASQQNTAHVPF
 1238- 1282 (69.05/32.38)	ATPTPGGSSFMNAPTPSDPGFDLNAESDltllDPSEESCAVILPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.40|      30|     196|    1143|    1172|      17
---------------------------------------------------------------------------
 1143- 1172 (57.12/33.57)	QDLMSKVRGPWRLAIVRHGYYEQSELLDWH
 1342- 1371 (57.28/33.68)	EDLIKQYRGLVTLGATRGCVDPNRECLPWH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33973 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PIVEEDTDVGQDPMQFVQDWILGTGGGTSNAEGGRQSVMDEDDEPLFADEGAFDD
2) PNPLFQKPVSSPSDSDSLMTSSSNSPDPASQQNTAHVPFRQWTEYHHPSPTAANRQSEID
3) PPAFGSSQPIYPTPPDVGMIHPTPGFPSVDGMALTPANFPRGPAERSQPPDEDMADFEDAHTSSGLQGLYDEDLFEENPDDNLCAETNGDEPNWDFFDGPGINPKPARSASHGRNEESVTRSDTQPAMAEANNDTDGQGAASQNPAIAKSENLHFNAAPKIPASTKSPQTRDQIEQPDSLLQAKSRLTPQPPSKRGPPLWKPEFATDPT
4) TAQTGTQNLYGTPASTPQGSMTSPEQTVPATPTPGGSSFMNAPTPSDPGFDLNAESD
347
669
410
1209
401
728
618
1265










Molecular Recognition Features






MoRF SequenceStartStop




1) LYDEDLFEE
478
486