<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33961

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNGERPAANGEHIANGFQQPVADSTPDAGHLKQGSLPQNPLPPSIDHTLTYANGEVGSSQQRSDNGGHNDTNLPPQAPSEILQLISQESYLPIAALINRASQSCWNGLSDLVTQLASMPVLELPPEQAKVLPNGLPNNQSKTNLDKKDRLLKFSNDQKADFIKLLVLLQWSKNVEEVSKTISINYWLMQRREAYWNAIGSMALLKQESSAFQIPNPDLRTAAEVLSRGRVLSFPHLGYNPQKDLSSRQILRILQSLNRALSVKLALSEDLPLHLRRFRIHDGRATFAVPNEFELDVSVLDDSIDSPFRVVDFRFSFQPSPHIPDRLHSEIELYANSNIDREGLKGCYDFLHELALSYKLAELHKQAIDLGRKQWAGNLRVELIRRNLIVQYWPERQFGKSWIEVGITSGRGKQASTKVESAPSLEIKWMRQGKRVDSLQLHLDDAVLCFEDILRQVIAQSSTQILDSIYDKLVLTPLFANAELFLEQSLSYAEPEACSLTIQVTRSSELQLKVDPVTGLLVLSPVTERTERLQYEINRIQGITDDIVSKLLNYRCSIMESMVLVGTLGTCWEVLRSFKLSQAEVKALFGGPVPRMNMLRQNQWTLDYTLAITHTSDGDHWWLLQQVSGGALKSPARYRVLHKQRIEVKEELCSAYFDRLAEYSMGLIFLQRNVDFFRDRKEKFDLRPLPAFGRHYELPEISFDLDMARPAFSKQPLPPAASAGASHLQMTNGPPKSATAQKGIQVRFGGVDRSTNKVRAIAQYQCQASSAVLRHLQESVLDASVTLNPEDRIGMIRVATPMAEAAIPEIVDKAMDLEKIVSTVEQIHRLPGLKLKTISHSSFTIAYHEGSPTELELRIGFPSGNQAPQLDFFPAQENPHQFLAAQYTKLIAASHGPFATRIRDFLTSLTLTLPLLTYLRNLQQKHGLDPERLQQTAPPEREDHLRVHILVRNATAFAIQYFTPAGQAPKDVKADSQPHMLARLEILHHINVSRKPMWLVRAALEEFQSYSRPSYSTPELGLKLKQEIFTRSDGQSKWLALDKAAACMADQPEPLLQAMHDLLWDWAKLAKSSEGKALNNQASNKAKAAPGHANATNTNLPNGTNSRISAPMKAPPGRMQPPGSAIPNGANVKAQRPPANFPGGRTMPPNHKANANTAQKQEVITLD
Length1166
PositionTail
OrganismCladophialophora psammophila CBS 110553
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Cladophialophora.
Aromaticity0.07
Grand average of hydropathy-0.375
Instability index51.47
Isoelectric point8.54
Molecular weight130339.12
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33961
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     168.82|      51|     278|     712|     805|       2
---------------------------------------------------------------------------
  726-  776 (87.46/117.93)	HLQMTNGPPKSATAQKGIQVR.........FGGVDRSTNKVRAIAQYQCQASSAVLRHLQ
  931-  990 (81.36/34.47)	RLQQTAPPEREDHLRVHILVRnatafaiqyFTPAGQAPKDVKADSQPHMLARLEILHHIN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     460.29|     153|     203|     169|     331|       3
---------------------------------------------------------------------------
  169-  331 (237.29/185.24)	QWSKN..VEEVSKTISINYWLMQRREAYWNAIG.SMALLKQESSAFQiPNPDLRtaAEVLSRG.RVLSFP.HLgyNpQKDLSSRQILR..ILQSLNRAL.SV..KLALSedlPLHLRRFRIHDGRATFAVPNEFELDVSVLDDSiDSPFRV..VDFRFSFQPSPHIPDRLHSEIE
  373-  537 (222.99/143.57)	QWAGNlrVELIRRNLIVQYWPERQFGKSWIEVGiTSGRGKQASTKVE.SAPSLE..IKWMRQGkRVDSLQlHL..D.DAVLCFEDILRqvIAQSSTQILdSIydKLVLT...PLFANAELFLEQSLSYAEPEACSLTIQVTRSS.ELQLKVdpVTGLLVLSPVTERTERLQYEIN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.85|      23|      25|    1099|    1121|       4
---------------------------------------------------------------------------
 1078- 1095 (23.13/ 8.67)	.....NNQAS.NKAKAAPGHANAT
 1099- 1121 (45.53/24.06)	LPNGTNSRIS.APMKAPPGRMQPP
 1125- 1148 (40.19/20.39)	IPNGANVKAQrPPANFPGGRTMPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.49|      25|      37|      77|     102|       8
---------------------------------------------------------------------------
   77-  102 (37.04/26.98)	APSEILQL.ISQESYLPiAALINRASQ
  116-  141 (39.46/24.08)	ASMPVLELpPEQAKVLP.NGLPNNQSK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33961 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EGKALNNQASNKAKAAPGHANATNTNLPNGTNSRISAPMKAPPGRMQPPGSAIPNGANVKAQRPPANFPGGRTMPPNHKANANTAQKQEVITLD
2) MNGERPAANGEHIANGFQQPVADSTPDAGHLKQGSLPQNPLPPSIDHTLTYANGEVGSSQQRSDNGGHNDTNLPPQAPSEI
1073
1
1166
81










Molecular Recognition Features






MoRF SequenceStartStop




NANANA