<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33959

Description Uncharacterized protein
SequenceMLRRETVATGEDRPTKRRKIEADTKSDHAVNYHNPSLPANAPDPNEDNKAVHWRWVKPSALRAAIANSQSKEEEGNSSEDDVPDLPSRPWRSTRAAKAADKPKPTHRSRVDIPVPNTPDSIQVPSSAPQFVPKRPVGFFPWTGKHPEDVLNDSNVKNGYFDKPPNPTEKELNTARIPLYNAFKHKSGVDSLSALFSLVLNQKSQYGLISSASTFKPPPRVTLTEAKRKSWIADLANADVPLRRLSRTIPQGIKGQTLLDQCLQNSVPLSRAIWFAKCVCANEIRTLKRKGTAPAVAMGTESKWFREWTVNVEEFLETRLEQSNPSDWRSDIQYALRLVTWLYLENLLDRGHYLDWILRSFTAADVGHTPFWLMVIHIYKQDLSHYRRRGTRLAEALINKYRSVDKLSDQTIAPLRQRLRAAIRELLFARPAIFLRPDSWPESLPVVRSCLDTTIRPEAQILEELSRINERTMGFNKAEFLSVRAPDEATIETLDAAAVPYNFTLLDEELAGTCLDFDLLVRSCLEWSCTRFRQSRTRIYVATRLVKRWQRGGQDVDTAILNFLSAFREGKTTADLHCLRHLIAQLSRADCFPLSKYMQWLMVRGLPEKGTVCINEDSIFEPTPGIEPRRESGSAQFLLDLSLQRAEDHVINLRNSVLQRAGFDLNSEEAIFGQCVRFLERKLAESSSITKPRPPALVEPSFASLPWTLRTRISMWLRTRALEGAKSAQSTPVLPGSKVLNEGQFFLIRHVLECMEDEAVLADVVGILSVSQRDDLVASLVATIHFHAGAFSAIGAFEVLQKRMCQVYMSWRPTKPTMPLLTSTLLDLCTAFPAKSPAIRLLQQDLVRGDRGRAVAACSPYSDGIAESLQQAGATFVEDFEAILQSETNMNEQTMNGLFSVLVDRIEKQQKFGDDPHTIQSFCQLLSRLRLCRRAQGDLLIQKWMSRLVPCLDAKSGPLLLQILIATGCITFAVVFDAAALSKPGPRKNLAVASLLYQILAPPNYTSLDWAAYQARTRWYEYSQREPSTALEILCEAGLRGVSPSFDSLLLDLLVNKSTSDSPSLPDSAEKWVVKALSRTLNCSDGDLTVAGLRALLKSINIFSHRFVQLRFRLTSQGSMEKVSGTDQADLTEVLSESLKETLQKPTSTYGQEQRFSQLLRIVGPDIASQVRHNVENEFLDALPKLPITKPTSPLSAVFPGDIQQLSLIVEQAFQVCRKDVSASPGFMSRLIDRLSQHLKYLGNVQLTPATPATPSAAPPTASGLAGSSMSVNHAQMMSVTSSPVATTSDSGSGSCSAVCLSYLRSMLQMVCLQRPALVSSGSNGPNAKQGQTEQVQLLVRLASIATHPAVAWTSGHQGSQEEQIKAKEVVDFAFDVIATVIDDVSDEVTTASAKLLKDRLNDPRLRYLFGSINMMGSAQVQDMGRGLQMVKEGKGIIGEWRPRMWEVLDNGSGKESETPLGLGLFRARYG
Length1470
PositionKinase
OrganismCladophialophora psammophila CBS 110553
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Cladophialophora.
Aromaticity0.07
Grand average of hydropathy-0.259
Instability index51.03
Isoelectric point8.72
Molecular weight163561.10
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33959
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.29|      16|      27|     314|     329|       1
---------------------------------------------------------------------------
  314-  329 (30.58/20.31)	FLETRLEQSNPSDW..RS
  342-  359 (26.72/16.69)	YLENLLDRGHYLDWilRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     185.15|      51|      71|     578|     631|       2
---------------------------------------------------------------------------
  578-  624 (67.93/49.17)	...........................LRHLIAQLS..RADCFPLSKYM...QWL..MVRGLPEKgtvCINEDSIFEPTPG
  625-  694 (62.36/37.04)	IEPRRESgsaqflldlslqraedhvinLRNSV..LQ..RAG.FDLNSEE...AIFgqCVRFLERK...LAESSSITKPRPP
  697-  765 (54.86/31.63)	VEPSFAS......lpwtlrtrismwlrTRALEGAKSaqSTPVLPGSKVLnegQFF..LIRHVLE....CMEDEAVLADVVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.92|      30|      30|      57|      86|       4
---------------------------------------------------------------------------
   57-   86 (49.92/31.76)	KP.SALRAAIANSQSKEEEGNSSEDDVPDLP
   88-  118 (48.99/31.02)	RPwRSTRAAKAADKPKPTHRSRVDIPVPNTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.22|      22|      31|    1314|    1335|       5
---------------------------------------------------------------------------
 1314- 1335 (37.95/28.49)	RPALV.SSGSNGPNAKQGQTEQV
 1347- 1369 (33.27/23.89)	HPAVAwTSGHQGSQEEQIKAKEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      21.24|       6|      67|    1173|    1200|       6
---------------------------------------------------------------------------
 1173- 1178 (10.91/ 7.99)	NVENEF
 1208- 1213 (10.33/11.85)	IVEQAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     268.54|      76|     297|     480|     569|       7
---------------------------------------------------------------------------
  370-  411 (50.30/22.82)	...................................FWLMVIHIYKQDLSHYRRRGTRL..AEALINKYRSVDKLSDQTI
  413-  476 (98.79/61.81)	PLRQRLRAAIREL.LFARPAIF..LRPDSWPESLP...VVRSCLD...TTIRPEAQILEELSRINERTMGFNK......
  481-  559 (119.45/111.67)	SVRAPDEATIETLdAAAVPYNFtlLDEELAGTCLDFDLLVRSCLEWSCTRFRQSRTRIYVATRLVKRWQRGGQDVDTAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     227.77|      76|     281|     915|    1006|       9
---------------------------------------------------------------------------
  915- 1006 (112.05/90.79)	PHTIQsfcqllsRLRL........CRRaqgDL.liqkWMSRLVPCLDAKSGPL.LLQILIATGCITFAVVFDAAALSkpGPRKNLAVASLLYQILAPPNYTS
 1199- 1288 (115.73/61.78)	PGDIQ.......QLSLiveqafqvCRK...DVsaspgFMSRLIDRLSQHLKYLgNVQLTPATPATPSAAPPTASGLA..GSSMSVNHAQMMSVTSSPVATTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     207.22|      89|     223|     795|     891|      12
---------------------------------------------------------------------------
  795-  838 (47.38/27.53)	..............................................................................................................................................................................................AFEVLQKRMCQVY.MSWRPT..KPTmplLTSTLLD.LCTAFPAKSPAI
  839-  891 (47.03/33.46)	RLLQQDLVRGDRGRAVAACSpysdGIAESLQQAGATFVEdFEAILQSETNMNE.........................................................................................................................................................................................
 1029- 1064 (29.50/ 9.56)	.....................................................qtmnglfsvlvdriekqqkfgddphtiqsfcqllsrlrlcrraqgdlliqkwmsrlvpcldaksgplllqiliatgcitfavvfdaaalskpgprknlavasllyqilappnytsldwaayqartrwyeysqrepstALEIL....CEAG.L..RGV..SPS...FDSLLLDlLVNKSTSDSPSL
 1074- 1146 (83.31/42.84)	KALSRTLNCSDGDLTVAGLR....ALLKSINIFSHRFVQ.LRFRLTSQGSMEK.......................................................................................................................................vsGTD..QADLTEVLsESLKETlqKPT.......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.29|      25|      28|     132|     158|      14
---------------------------------------------------------------------------
  132-  158 (43.15/33.93)	PKRPVGFFPWTGKHPedVLNDSNVKNG
  163-  187 (45.14/28.72)	PPNPTEKELNTARIP..LYNAFKHKSG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33959 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MLRRETVATGEDRPTKRRKIEADTKSDHAVNYHNPSLPANAPDPNEDNKAVHWRWVKPSALRAAIANSQSKEEEGNSSEDDVPDLPSRPWRSTRAAKAADKPKPTHRSRVDIPVPNTPDSIQVPSSAPQ
1
129










Molecular Recognition Features






MoRF SequenceStartStop




1) EDNKAVHWRWVKPSALRAAIA
2) KRRKIEA
46
16
66
22