<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33957

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTVSKWTAIARQCLRRRISVQQFGDLLQAHDGEIAVRRLFDALVDCRESFCAPGDPLVSLYIDHLGSTGAISVSDALLVLTKRWNNAKGQLSQDVVACYNQTVQDLTMIMIGPKYKLEASEARVALSLSSRWLSAVARQASREDGERTGLEYNATVESLAFFVASLAATDAGLEALSPNVTSKREGLDGPLSDLRASMRQAFELCLPLYSVLSSQLVERINTVLKHISLLDGGRPQESNMSTQASEIQALQFQVSIAESQLVASKAGTMLFLSSLLLTSSTIDDGTAVNWLSSRHHNDYQAMFSDIFTTSFAILKCQNSTPRQNLCMQQCQIFIQNKLPALLSMISATSFNGFSTEQAISDAWHQVVPLLSEHDLLAIGAHFLHVCSLIHLLPGQMVSQLVGNEDLLKGLSKGLYTKDGLVERVNSNHARGPKLVEELIRGDGSAGFISQAIVEIMHSYCQSKETQYLKELANAIIRKPAAINCVALFIRPSFFLSPLCSLLDDWRWDEIHGEAQPVYDDFGAIFLLILVTKARLDLPNSGLGIRKKGGFLSEYLRHENYEHSLDDLSEEKKSHLGNWINALYLAEGLSDELFTSCSPHDFYLLIPTLLRQSVTAYQQGKLTHDALKAGLDYLLEPFLLPSLISALGWAGEVFHQDSAVIGKVLDVLTKAPGTIESRDIHHTILAMCGPRLKLRLTTSASKDSNIGSVLTTLDKCPDFTLAAEREVQNEGPGVVSLLQHSLATLITSANTLHPEQQVSLHDIPALMNRTVEIRGAEVALRALIGVLLQLSDSHQFLFALDAVTTVICMGGEGLHAALRLLYHNLGGTLRSGDTLTAEAVVRLYRQVEAYKNLLTVQEMGLDTIFGQQLTDIDTANPNLDAATAVSGGGGGGVVDMQAAEQGEPDGIDQVLDEVAAMGNLDTSDADMNFDTLYGLEGNEMDLNDLDLDMF
Length949
PositionTail
OrganismCladophialophora yegresii CBS 114405
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Cladophialophora.
Aromaticity0.06
Grand average of hydropathy0.030
Instability index35.52
Isoelectric point5.02
Molecular weight103600.83
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33957
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.03|      23|      30|     602|     630|       3
---------------------------------------------------------------------------
  602-  624 (40.74/33.72)	YLLIPTLLRQSVTAYQ.QGKLTHD
  632-  655 (36.29/16.74)	YLLEPFLLPSLISALGwAGEVFHQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     351.65|     118|     359|      83|     221|       4
---------------------------------------------------------------------------
   83-  221 (169.90/140.10)	RWNNAKGQLSQDVVA.....CYNQTVQDLT................MIMIGPKYKLeasEARVALSLSSRWlsavarQASREDGERTGLEYNAtveslaFFVASLaATDAGLEALSPNVTSKREGldGPLSD.LRasmRQAFELCL.PLYSVLSSQLVERIN
  440-  580 (181.74/106.00)	RGDGSAGFISQAIVEimhsyCQSKETQYLKelanaiirkpaaincvALFIRPSFFL...SPLCSLLDDWRW......DEIHGEAQPVYDDFGA......IFLLIL.VTKARLDLPNSGLGIRKKG..GFLSEyLR...HENYEHSLdDLSEEKKSHLGNWIN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.37|      41|      64|     768|     829|       5
---------------------------------------------------------------------------
  768-  812 (58.68/42.34)	RTVEIRgaEVALRALIGvlLQLSDSHQFLFALDAVTTVICMGGEG
  851-  891 (71.69/63.88)	NLLTVQ..EMGLDTIFG..QQLTDIDTANPNLDAATAVSGGGGGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.47|      31|     374|      25|      58|       6
---------------------------------------------------------------------------
   25-   58 (50.57/36.48)	DLLQAHDGEIAVRrlfDALVDCRESFCAPGDPLV
  405-  435 (52.90/30.42)	DLLKGLSKGLYTK...DGLVERVNSNHARGPKLV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33957 with Med5 domain of Kingdom Fungi
Unable to open file!