<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33956

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNGERPTVNGAHTANGTHRSVTDSSSSANPLKPGLLPQNLLPPPPPPSLDRQENGDAWSNRWDDGGAGHAAASNQTHAPPEILSLISQDSYLPMAALISRASQTCWNGLSDLVEQLALLSVPDLPPEQAKLMPNGFTNNQSKANLDKKDKIFKFANERKADFIKLLVLLQWSKNVDEVSKTISINYWLMLRRQAYWGAIASMATLKQESSNFQIPNPDLKTAAEVLSTGKVANFPRLGYIAQPDLSTRQILRVLKTLNQALSVRLALWDNLPPQLRSFRVHDGRATFSVPYEFELDVSTLDESLESPLRMVDLRLSFQPCPHLPDGLRSEIELLANSNIDQGGLARCYEFLHELALSYKLAEFHKQAIELSRNQWVGNLRAELVRRNLVVQYWPERHGGKSWVEIGIASGRGKQRAVDMEPHSSLEIKCTLHGKRAESLRLHLNESVLCFEDILRQVIAQHSTQILDTIYDKLVSRPLFADAELSLEQSLSHDDPEVCSLVMQLSRSSQLQLKVDPVTGLIMVSPVTERAERLQFEVNRVQSVADEVVSKLLNFRCSVRESSVLAGISGARWEALRSFKFTQAEIKSLFGRPVVKINIFRQSQWGLEYSLAVTHGQDGDHWWLLQQVPLGASSSQSRYKVLRNQGIGASEELSSAYFDCLADYSMGLICIQRNADFFTEKKENFGLRPFPAFDRHYELPELSFDLDMARPSPSGQSSSAGAADSTPTTPKASDVPAEDASLQRNVQVRFGGVDRSDLRVVTVAHYQTQASSAVLGHLDKSVLDAGVKLNPEDRTVIIRVETPMAEAAIPQIVAKVLDLEKVVSTVEQIHCLLGLRLKRISNSTISMVYHQEALTELGLNIILTSGSPAPRLEFLPPQVNPHQILAQAYTKTFAANRAPFATTMRNLLTSLTATLPLLTILHTLQQGHEFASKPGQQQPPAEPGDHVRVHLLARTETQFAVQYFTPAGQAPNDVKNDSAPQLLARFEILSEANHSGKAGWLVRPALEEFQSYSRPSYSSPDLAAKVKQEIFSQRPAGQSTWFLLDRGAWCTVDHPEPLLKALHDVVWNWAKQAKMSAGNAGSKEDSNKGKGAQGGSNANNPSVTNGANNRGPGPAKGAPGRQQAANNAMPNGANMKVQRPPVNGPGGKPAPNNAKTNARNPQGRDVITLD
Length1169
PositionTail
OrganismCladophialophora yegresii CBS 114405
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Cladophialophora.
Aromaticity0.07
Grand average of hydropathy-0.363
Instability index48.27
Isoelectric point7.66
Molecular weight128742.28
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33956
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     149.86|      44|     184|     933|     980|       1
---------------------------------------------------------------------------
  865-  909 (43.96/22.17)	.GSP..APRLEflP.PQVNPHqILAQAYTKtFA......ANRAPfaTTMRN.LLTS
  933-  980 (66.06/52.64)	PGQQ..QPPAE..PgDHVRVH.LLARTETQ.FAVQyfTPAGQAP..NDVKNdSAPQ
 1003- 1037 (39.84/19.09)	PALEefQSYSR..P.SYSSPD.LAAKVKQE.IFSQ..RPAGQ..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     296.36|      85|     185|     110|     197|       4
---------------------------------------------------------------------------
  110-  190 (118.83/82.39)	..................................SDLVEQL.A.LLSVPD..LPPEQAKLMPNGFtnNQSKANLDKKDKI........FKFANE.....RKADFIKLLVLL...QW...SKNV..DEVSKTISINYWLML
  192-  263 (95.08/61.05)	RQAYWG.....................................aIASMAT..LKQESS.........NFQIPNPDLKTAA........EVLSTG.....KVANFPRLGYIA...QPdlsTRQI..LRVLKTL..NQALSV
  264-  393 (82.45/47.54)	RLALWDnlppqlrsfrvhdgratfsvpyefeldvSTLDESLeS.PLRMVDlrLSFQPCPHLPDGL...RSEIELLANSNIdqgglarcYEFLHElalsyKLAEFHKQAIELsrnQW...VGNLraELVRRNLVVQYW...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.41|      25|      50|    1076|    1110|       5
---------------------------------------------------------------------------
 1086- 1110 (46.18/35.41)	NKGKGAQGGSNANNPSVTNGANNRG
 1112- 1135 (40.86/14.44)	GPAKGAPGRQQAANNAMPNGANMK.
 1143- 1162 (34.37/12.77)	..G...PGGKPAPNNAKTNARNPQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.48|      18|      33|     766|     783|       9
---------------------------------------------------------------------------
  766-  783 (28.38/15.08)	QTQASSAVLGHLDKSVLD
  800-  817 (29.10/15.62)	ETPMAEAAIPQIVAKVLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     105.87|      25|      46|     533|     557|      10
---------------------------------------------------------------------------
  510-  532 (30.74/19.40)	LQLKVDPVTGLI..MVSPVTERAER
  533-  557 (40.43/28.05)	LQFEVNRVQSVADEVVSKLLNFRCS
  578-  602 (34.70/22.93)	FKFTQAEIKSLFGRPVVKINIFRQS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33956 with Med14 domain of Kingdom Fungi
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