<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33945

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMNHLNLMDQDPPDDFASDSFFDQNSLQQQIQQIDAGADLSDADINGTVPSVAIPPNPAVVEQLARKWYSGCLERIAWSRHGHLAGISEDGSTVYLECLRYDHGSKSWGLHERHSLTTVFEEAISLAWSATGGELAVVDIKGRVWIYHVALTAINRLNLARQGAIDEGDDYSQPIGLTWLNQDRQERPRNVVTHASKGETRWEHANSRAKPLGTYWPRAALIVHRNGLTTLCFQRRDGQYLRIIKQLTPQDGVLYTHASFAPTIDGKMLIAIHSYQKVISAVLLAIDWTEVNQGLEGLPVLTIDPVSSKVSSYPSGSAAVPDTFDPESWLLSHLTMVQTSDVEKAVQTPPTILAVLTGVNRTASIPDAGFLVSSLIKRWTVKSVETKLHPLFDALPSTGSAAAAPKPLYVLQEQPDKEEQVIITVHHIDGVQTLAITTQENRTDFLSLEDLTPMSYAASAQETSCMAQSGFTFPYTQTILDPSFSPGACVRADLTANGKTQLAVMEHHLEQHQIQQPLDPHVDAAIAALNLTFARACWSNATIDDILMCASRTIPPALIPTVISSVYRTLFRDGEFVHEKTPGSELERMFHKQVMAKVFSYHASLASTCSQLVSVASTDGRTGGWTLSAQWAWIVNNVRQTTTLLFMNLRDIQNVTIVVGQDFTDMLCANLRWGLSLIRFIFNAILEVGDRESNPDMFDGKDRGRLGDTHGDGSQGLVALLLNCHASRIFLIAFVRAVRTYAKITEPKSQHQLQVLQCIQQQTNGKGLSFGAIEALLEYRWSAAGDVEGNIAATAVRQLDMMATGIVHEAYQPTIKTLLSKLVNSPSGLRAKMLVDRLKLFVDHVDLEYIFLNPGILGHRRGGRSTEIIYDVLRKRPITKGTAEPHGAGQPMVRKCIRCGSFSEDVVVPPKEWPRQIALSLARCVCDGNWVLEPWEKVHK
Length939
PositionTail
OrganismCladophialophora yegresii CBS 114405
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Cladophialophora.
Aromaticity0.07
Grand average of hydropathy-0.135
Instability index35.86
Isoelectric point6.08
Molecular weight103772.96
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33945
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.67|      56|     562|     261|     320|       1
---------------------------------------------------------------------------
  261-  319 (83.92/64.40)	PTIDgkMLIAIHSYQKVIsAVLLAIDWTEV..NQGLEGLPVL...TIDPVSSKV....SSYPS.GSAAV
  337-  402 (66.75/38.06)	QTSD..VEKAVQTPPTIL.AVLTGVNRTASipDAGFLVSSLIkrwTVKSVETKLhplfDALPStGSAAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.61|      23|     695|      23|      45|       2
---------------------------------------------------------------------------
   23-   45 (40.24/25.91)	QNSLQ..QQIQQIDAGADLSDADIN
  749-  773 (38.37/24.38)	QHQLQvlQCIQQQTNGKGLSFGAIE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     305.44|      96|     469|      63|     161|       4
---------------------------------------------------------------------------
   63-  161 (160.29/109.11)	LARK.WYSGCLERIAW..SRHGHLAGISEDGSTVYLECLR...YDH....GSKSWGLHERHSLTTVFEEAISLAwSATGGELAVVDIKGRV..WIYHVALTAInrLNLARQ
  532-  639 (145.15/88.11)	FARAcWSNATIDDILMcaSRTIPPALIPTVISSVYRTLFRdgeFVHektpGSELERMFHKQVMAKVFSYHASLA.STCSQLVSVASTDGRTggWTLSAQWAWI..VNNVRQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33945 with Med16 domain of Kingdom Fungi
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