<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33944

Description Uncharacterized protein
SequenceMSDIGDDRPAKRRKMEGEGQLLEHAPSHNTLTPVLSQPADAGDDDRTVQLRWVKPSAIRLRAGNFPVKDEENGDGEDDVPELPPRPWRTNQAFNAVEEPKPSHRSRVNIPVPNTPDSIELPSAVPHFVPRKPAGFFPWTGKHAEDVLSDTNVKTGYFDKPPNPTEKELNTARVPLYNAFKHKSGVDSLSVLFSLVLDQKSLHGTTSSVSTFKPPPRVTLTEAKRKSWIADLANADVPLRRLSRTIPQGIRGQALLDQCLQSDVPLSRAVWFAKCVCANEIRTLKRKGTTPTVAVGTEGKWLREWTVSVEQFLEAHLARSSSPDWKTNIQYALRLTTRLYLENLLDRDHYLDWILRSLASADVGHTPFWLMVTHIYKQDLSQYRRRGSRFVEALINKFRPVDKIQDSTIAPLRLKLRAALRELLFARSALFLMPDRWPESMEIIKACLDQTLPAERQLFDGLNRINERAMGYNKAEISSTRAPDQALVNILDSARVPYNLTDLEATLKTACSDFSLLIQTCLEWSCTRFRCSRSRVYLITRLVKRWQREGLDVDTALLNFLSAYKEKRTTADSQNLRHLMAQLSRSDCFNISRYLQWLMVRGLPKHGTVRIDTSAIFGSAAGTWHEDAPEATHFLLDLSLNKAEDHIVNLRRAILERASFDPNSEEAAFRKCIRFVEQGLAGPNSASSSQTPSVTEPAFDLLPWTIRTRISMWLRARALEGAKAEQTGPALPGSRVLNEGQFFLIRHVLESMDDEAVLADVVGILYTSKNDDLVASLVATIHFHADAFSAIGALEFLQKQMCQVYMTWRPTKPTMPLLTSTLLDLCTAIPSKMPTIKLLQQDLVRGDRGRAVAACSPYSDGIAESLQQAGATFVEDFEAILQSETNMNEQTMNGLFSVLVDRIEKQQKFEDDPHTTLSFCQLLSRLRLCRRGQGDLLIQKWMSRVLPRLDSKWGPLLLRSLLSTGCITFDALLGAVATSKHGTRRNVAFASLLYQILAPTKGTAPDWAAYQTRTRWYGYVQREPKTVLEVLCEAGLQGFSPKFDSLLLSLLVNGSPLSSSVLSGGVRQWFLKTLSRSLNCRDGELTATDFRALFRTMNIFSHPYVQLRLRSMPASAAEKDLGANHDELADVLYASLQNTMPTSARSSSKGQDRRFAHFLQTVGPEVASSIRHRVENEFLEASPKLPLGKATSPLTASFPGEIQQLGSIIERAFQVCRQDTVPSAGFMSQLIDRLSQYFKSLAFASVAPSTPVTTGHPAIPGLSAPTAATNASQMVAAPSTPTISASENGPSVCSVPCLSYLKYMLQMVCLQRPALILAGSTGPNSKQGQSEQVQLVVRLASIATHPAMAAASKQHGNKEQQALAKDVILSMFDIIATIVDEVSDEVNMMCAKLLKDKFHDGRIRYLFGSINMLGSAQVQDTGQGLQLTKEGKGIIGEWRPRMWEVLNNGSGKETETSLGLGLFGARYG
Length1467
PositionKinase
OrganismCladophialophora yegresii CBS 114405
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Cladophialophora.
Aromaticity0.07
Grand average of hydropathy-0.252
Instability index48.99
Isoelectric point8.87
Molecular weight163038.60
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33944
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.59|      26|      27|     415|     440|       1
---------------------------------------------------------------------------
  415-  440 (46.26/30.54)	LRAALRELLFARSALFLMPDRWPE.SM
  443-  469 (41.33/26.42)	IKACLDQTLPAERQLFDGLNRINErAM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.27|      25|      27|    1224|    1250|       2
---------------------------------------------------------------------------
 1224- 1250 (39.96/28.68)	GFMSqlIDRLSQYFKSLAFASV..APSTP
 1254- 1280 (41.31/23.56)	GHPA..IPGLSAPTAATNASQMvaAPSTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.86|      18|      26|    1103|    1128|       3
---------------------------------------------------------------------------
 1103- 1121 (27.06/31.55)	YVQLRlRSMPASAAEKDLG
 1132- 1149 (31.79/13.56)	YASLQ.NTMPTSARSSSKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.87|      14|      25|     311|     324|       4
---------------------------------------------------------------------------
  311-  324 (26.91/17.69)	FLEAHLARSSSPDW
  339-  352 (27.96/18.71)	YLENLLDRDHYLDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     147.56|      39|      74|      59|      99|       5
---------------------------------------------------------------------------
   59-   99 (65.87/49.71)	RLRAGNFPV..KDEENG.DGEDDVP....ELPPRPwrTNQAFNAVEEP
  104-  130 (31.39/14.83)	RSRV.NIPV..PNTPDSiELPSAVP....HFVPR..............
  132-  174 (50.31/29.87)	..PAGFFPWtgKHAEDV.LSDTNVKtgyfDKPPNP..TEKELNTARVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.71|      14|      33|    1413|    1426|       6
---------------------------------------------------------------------------
 1413- 1426 (24.75/14.39)	GSAQVQDTGQGLQL
 1448- 1461 (23.96/13.70)	GSGKETETSLGLGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.13|      33|      33|     665|     697|       7
---------------------------------------------------------------------------
  665-  690 (37.66/23.77)	.............EAAFRKCIRFVEQGLAGPNSASSSQT
  691-  726 (43.46/28.80)	PSVTEPAfdllpwTIRTRISMWLRARALEG...AKAEQT
 1333- 1352 (26.02/13.68)	QLVVRLA......SIATH............PAMAAASK.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.35|      20|      28|     576|     596|      14
---------------------------------------------------------------------------
  576-  596 (33.32/25.94)	RHLMAQLSRSDCFNiSRYLQW
  604-  623 (35.02/22.26)	KHGTVRIDTSAIFG.SAAGTW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33944 with Med12 domain of Kingdom Fungi
Unable to open file!