<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33940

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMNATSDFPGNCQTNVYTLNDFGEIAYIVCTAANPPTHDPSAFAATPENILARLRTTERQFRENSILAALDVEARQLFTFYKKVDITAPKDQKALLMKFGFVLRSNSCTIAYKTAARLPDLMKPEQARLYRLFITAIVSSVKLFPVGNTALQAVGSNLYLVETAPPATEHDSFAERRTWVLYRIDLQVALNGHIVLTIAKDSKLSFLPLHHCLAGADSEARRSAFRAVYLAPVGRIARVSLSKLAAQRDLNGGLAEEHSGEAPISDTRRETWRHLLPSWLKEHMDIAIQASDVLWIEAEVPVEELGHISNNNQADVTNAEGGSGNPITWKPIFWPANLCFVLEGNSTAQTSIIEDDSDPIQFAGDWILGIGSAPTKTETGSQVFKEDEEDEPLFADDGTFDDPEHFQPFGPPAFPASQTIYPTPPDVGITHPTPGLSSVDGVVMTPVNLSGGSAELAQQHDEEMPDYDDVPPTSAMSGYYDEDLFEEMPDDNFGKEANGDEPNWDFFDGPGVPPKQSRSASHSRKEGSTSRGDHKQERVDPSDAKTDGGPLHSVKNETITVGDSPHIPTGAQPQVPKAQTAGKDTALSLNDDKVIQSPPKPAPPLWESEQGRATASTINTRRRSSIYDSPKALHSIPIHDSRYDAEGEYWFNPLPLVSRLRTRPKSGSVFERPSSPSDSDSSMTSLSQSPKANSTGNVVPPPFRQWTEYDPGSQDANSHQKEFDKKTIQQEVLQLLGLMRPVLVEPPTANDFELDEPDPHKTPLTTSQKPQHVAQVLVDQMSQTSLLAHGEYQGDMRISPGECIEMNVDLSGINTSSGPSNLFQLTNLKVDHSSTRVQGRVIKIRASQICLRRIERPLTANISILNFWDTLDLQPANGQKHVTAFCIHPHRTNIRDGCLNLLQRLSDSYTTCDLGTHTIGHLPGVTDDGLISWNPDDPGERSLVQCTTIVGSALAATTSISGTVVVYMVSRGESPTAYLEMCIAFYNLFEAFSRARTSSVCVSDLQLQIVPQSFIANTETLIIRPQTAYFKLAVEVYNRLPPLDSAGHPSACGSAVVLSRSENTVRLQLSPTYVSPLEKNGPCLHLAYSMSLDKKWLAAAWTDELGHTALSMSYCSHVHKSGRRRPRQEILKEMWEVSHDLMSKVRGAWRLAVVRHGYFEPAELLEWQRIVDVSPTPQKQCLLLLLSIQLQPELAVFPPPPHGKPTLSGAHNQYGTPVSTPQASITSPDQAVPATPTPGGSSFMNPSTPSDPGFDPNTESDLTIVDPSEESWGIILPYGINQSRSMTELRPSQVTGFLMKRRGPRGEDGYNMIEISLLKSITQTSNKPNEVMPDDLLDDVIRQYRGLVTLGASRGCVDPSRECLPWHIATAIRGARILEQAM
Length1381
PositionKinase
OrganismCladophialophora yegresii CBS 114405
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Cladophialophora.
Aromaticity0.07
Grand average of hydropathy-0.401
Instability index51.44
Isoelectric point5.30
Molecular weight151714.67
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33940
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      63.94|      14|      19|     410|     423|       1
---------------------------------------------------------------------------
  410-  423 (26.51/14.29)	P.PAFPASQTIYPTP
  431-  445 (19.59/ 8.24)	PtPGLSSVDGVVMTP
  460-  472 (17.83/ 6.71)	D.EEMPDYDDVPPT.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.41|      44|      49|     976|    1024|       2
---------------------------------------------------------------------------
  976- 1024 (67.06/55.44)	AYLEMCIAFYNLFEAFSRARTSSVCVSDLQLqivPQSfiANTETLIIRP
 1027- 1070 (76.35/48.36)	AYFKLAVEVYNRLPPLDSAGHPSACGSAVVL...SRS..ENTVRLQLSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     218.95|      46|      49|     602|     647|       3
---------------------------------------------------------------------------
  477-  518 (67.08/30.48)	GYYD.EDLFEEMPDD.NFGKEANGD...................E.PNWDFFDGPGVPP......KQSRS
  519-  572 (48.81/20.32)	ASHSRKEGSTSRGDHkQERVD.PSD..............aktdgG.PLHSVKNETITVGDsphIPTGAQP
  573-  623 (39.32/15.05)	QV...PKA............QTAGKdtalslnddkviqsppkpaP.PLWESEQGRATAST...INTRRRS
  624-  674 (63.74/28.62)	SIYDSPKALHSIPIH.DSRYDAEGE...............ywfnPlPLVSRLRTRPKSGS...VFERPSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     174.11|      53|      57|     689|     745|       4
---------------------------------------------------------------------------
  343-  391 (74.65/42.20)	GNSTAQTSIIEDDSDPIQFAGDWILGI......gSAPTKTETGSQV...FKEDEEDEP
  685-  710 (34.10/13.80)	...............................LS.QSPKANSTGNVVPPPFRQWTEYDP
  711-  760 (65.36/45.29)	GSQDANSHQKEFDKKTIQQEVLQLLGLmrpvLV.EPPTANDFELDEPDPHK.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.65|      30|     915|       7|      45|       5
---------------------------------------------------------------------------
    7-   43 (50.04/46.31)	FP.GNCqtnvyTLNDFGEIAYIVCTAanPPTHDPSAFA
  143-  173 (51.61/25.16)	FPvGNT.....ALQAVGSNLYLVETA..PPATEHDSFA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.40|      36|      46|     820|     855|       7
---------------------------------------------------------------------------
  820-  855 (58.58/39.96)	NLFQLTNLKVDHSSTRVQGRVIKIRASQI...CLRRIER
  865-  903 (60.82/41.78)	NFWDTLDLQPANGQKHVTAFCIHPHRTNIrdgCLNLLQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.33|      21|     916|     307|     327|      12
---------------------------------------------------------------------------
  307-  327 (38.72/23.02)	ISNNNQA.DVTNAEGGSG..NPIT
 1224- 1247 (31.61/17.23)	ITSPDQAvPATPTPGGSSfmNPST
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33940 with Med13 domain of Kingdom Fungi
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