<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33938

Description Cyclin-dependent kinase E-1
SequenceMGDGSGNRGVTHSNNNNNGGGGTSNKPEWLQQYDLIGKIGEGTYGLVFLARTKTPGNRGKSIAIKKFKQSKDGDGVSPTAIREIMLLREISHENVVKLVNVHINHADMSLYLAFDYAEHDLYEIIRHHRDKVNHAINQYTVKSLLWQLLNGLNYLHSNWIIHRDLKPSNILVMGDGEEQGVVKIADFGLARIYQAPLKPLSENGVVVTIWYRAPELLLGAKHYTSAVDMWAVGCIFAELLTLKPLFQGAEVKATPNPFQLDQLDKIFKVLGHPTLEKWPTLANLPHWQQDSQHIQGHKYDSHGLHSFVHLSPKSPAYDLLSKMLEYDPRKRITAAQALEHEYFRIEPLPGRNGLVPFQGEKVVNYPTRPVDTTTDFEGTTSLQPSQPVSSGNAVSGNMPGAHGVPSRNATRPPMGMQRMPPQGMAGYNLAGGVMNPGGIPMQRGVNPQAHQQQQLRRKDPGMGMSGYPPQQKQRRM
Length476
PositionKinase
OrganismMorus notabilis
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Moraceae> Morus.
Aromaticity0.08
Grand average of hydropathy-0.514
Instability index40.33
Isoelectric point9.30
Molecular weight52933.71
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33938
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.87|      25|      49|     396|     422|       1
---------------------------------------------------------------------------
  348-  385 (27.95/ 7.59)	LPGRNGLvpfqgekvvnyPTRpvDTTTDFEGTTSLQPS
  398-  422 (53.15/27.99)	MPGAHGV...........PSR..NATRPPMGMQRMPPQ
  447-  470 (39.78/17.05)	.PQAHQQ...........QQL..RRKDPGMGMSGYPPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.07|      26|      50|      20|      47|       4
---------------------------------------------------------------------------
   20-   47 (43.48/37.83)	GGGTSnkPEWLQQYDLIGKIG.EGTYGLV
   73-   99 (38.59/26.30)	GDGVS..PTAIREIMLLREIShENVVKLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.02|      28|      42|     171|     200|       5
---------------------------------------------------------------------------
  171-  200 (43.82/39.17)	LVMGDGEEQGVVKIADFGLarIYQA..PLKPL
  216-  245 (45.20/33.08)	LLLGAKHYTSAVDMWAVGC..IFAEllTLKPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33938 with CDK8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) VPFQGEKVVNYPTRPVDTTTDFEGTTSLQPSQPVSSGNAVSGNMPGAHGVPSRNATRPPMGMQRMPPQGMAGYNLAGGVMNPGGIPMQRGVNPQAHQQQQLRRKDPGMGMSGYPPQQKQRRM
355
476










Molecular Recognition Features






MoRF SequenceStartStop




1) QLRRKDPGMGMSGYPPQQKQRRM
2) RGKSIAIKKFK
454
58
476
68