<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33933

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMGTIILFWKDVWGGNQSLEHSFTRLFRAFDIPFACIDDILSMSSNNELNWVFLFKEGLNDRSRGFAILYINSVILSFSLGEIIWLHLLCSVFNAELMEKPLTTFNYTVGCADNADYMEGLNEVYSKRSQHGYNSSSNSNCSSISSISSSSSDSDYKMNSGANELEADADSLTCRQSGLSSNDQLENDFPRLGSKRPRAGMTDSFGQMGAAAIVPMQDSYKSDLGSLEVNNSGITGVGNDQIGCYWDWDDDDRDMGTDIRALLHEFGDFGDFFENDALPFGEPPGTAESHALMFSGPDCGDILSSPVGIMDVSDQLLSTEGFTPFDSFSQPPPAPNEEIISKNQGVMNNSSLGLVNTSLAFSTSEFDHIIKAEALMTFAPEFGAVEAPTSELSSSIFRSPYFPKSRKVESSSSSSNTYTYGATPPSSPCFDGSDEKTGILVNSNTSTVKPSSSATLQSKNWYTLVESVKDQHDRRSSNNSVVTSEGMGSSISNINPVNDIKGAPRKIADSTLRGDNIFLSMKTVLSTEIECIMFQASMCRIRHTLLSSSSPMPVGLSRLTPSTILNQLPNDHSVMTDNISGKYEVEKKESIPVRIAGDIDGGMLDGHLNAPVGVWRSVSVPRVSKPTNSPSMEVNPSLPHNPFNEEGMLSYGQRQPLQELLDGMALLVQQATSFVDLALDTDCGDGPCGLLALQEQWRKGFSCGPSMVHAGCGGTLASCHSLDIAGVELTDPLSADVYASSVISLLQSDIKTALKSAFDALDGPLSVTDWCKGRNQSGESGSVGDGYSAESTITECRDSSGSAAVSIGDSMSPSQSSGGPSGFKDGGKMDETGQRRSNQENCGSEGEQQNFFRLRPSLFVVPLPSILVGYQDDWLKTSASSLQLWEKAPFEPYALQKPITYCVVCPDIDPLTSAASDFFQQLGTVYETCKLGTHLPQSFGNQMEVDSGKCLSPGFILLDCPQAMRIESGNASLVGSISDYFLSLSNGWDLTSYLKSLSKALKALKLGQCMSTNTREGSSSSCMVIYVVCPFPEPTAVLQTVVESSVAVGSVIFQSDRERRSVLHSQVAKALSCSASVDEASISNVLVLSGFSIPKLVLQIVTVDAIFRVTSPSLSELVILKEIAFTVYNKARRMLRGSSNDAVHSSSLSGRSHSVMTQMPSPTPGMWKDCIGPRIAGHSLPREGEIDSSLRHGTWDNSWQTRSGALACDPNRMGDYFLQDEIRYMFEPLFILAEPGSVEHGYTPFGFGNLSSESSKTLLDDSYMQSASSVGSGDAASNSHIDGSDMDKNPPSIHCCYGWTEDWRWLVCIWTDSRGELLDSQIFPFGGISSRQDTKGLECLFIQVLQQGCQILQACSSDTGVARPRDFVIARVGSFYELEYQEWQKAINSVGGAEVKKWPLQLRRSVSDGIPANPNGTSLQQQEMSLIQERNLPSSPSPLYSSPHTKTSGFMKGGLGQPTSRKQIMSGHAVIDSSKSLLQWVQSISFVAISVDHSLHLVCQADSTSPGGSQGGLYSGSSTYLEGFTPVKSIGSISASYILIPSPSMRFLPPTPLQLPTCLTAESPPLAHLLHSKGPAIPLSTGFVISKAVPTMRKDCRNSLKEEWPSALSISLVDHYGGNNFSQEKMARGLMKQGGRSSSSELKEFEIETHLILESVAAELQALSWMTISPAYLERRTALPFHCDMVLRLRRLLHFADKELSRRPEKSQNVG
Length1710
PositionKinase
OrganismMorus notabilis
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Moraceae> Morus.
Aromaticity0.08
Grand average of hydropathy-0.233
Instability index55.39
Isoelectric point5.01
Molecular weight185356.11
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33933
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     334.00|     110|     125|    1397|    1521|       1
---------------------------------------------------------------------------
 1397- 1521 (163.26/114.92)	W.PLQLRRSVSDG...IPaNPNGTSLQQQEMSLiqERNLPSSPSPLYSSPHTKtsgfmkgGLGQPTSRKQIMSgHAV....IDSSKSL.LQWVQSISfVAIsVDHSLHLVCQADSTSPG.GSQGGlySGSSTYLE
 1523- 1642 (170.74/84.72)	FtPVKSIGSISASyilIP.SPSMRFLPPTPLQL..PTCLTAESPPLAHLLHSK.......GPAIPLSTGFVIS.KAVptmrKDCRNSLkEEWPSALS.ISL.VDHYGGNNFSQEKMARGlMKQGG..RSSSSELK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     751.71|     255|     301|     649|     948|       2
---------------------------------------------------------------------------
  654-  948 (389.27/323.94)	QPLQELLD.........GMALLVQqatSFVDLALDTDCG.DGPCGLLALQEQWrKGFSCGPSMVHAGCGGTLASCHSLDIAgVELTDPLSA..DVYASSVI...SLLQSD..IKTALKSAF.DALDGPLSVTDwckgrnQSGESGSVGDGYSAESTITECrdssgsaaVSIGDSM...SPSQSS...GGPSGFKDGGKMDETGQRRSNQENCGS..EGEQQNFFRLRPSlfvvPLPsilvGYQDDWLKTS............ASSLQ..LWEKApfepYALQKPITYCvvcpdiDPltSAASDFFQQ..LGTVYE....TCKLGT....HLPQSFGNqMEVDSGK
  951- 1255 (362.43/212.14)	SPGFILLDcpqamriesGNASLVG...SISDYFLSLSNGwDLTSYLKSLSKAL.KALKLGQCMSTNTREGSSSSCMVIYVV.CPFPEPTAVlqTVVESSVAvgsVIFQSDreRRSVLHSQVaKALSCSASVDE......ASISNVLVLSGFSIPKLVLQI........VTVDAIFrvtSPSLSElviLKEIAFTVYNKARRMLRGSSNDAVHSSslSGRSHSVMTQMPS....PTP....GMWKDCIGPRiaghslpregeiDSSLRhgTWDNS....WQTRSGALAC......DP..NRMGDYFLQdeIRYMFEplfiLAEPGSvehgYTPFGFGN.LSSESSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     320.62|      86|     122|     199|     320|       3
---------------------------------------------------------------------------
  206-  305 (141.49/116.66)	QMGAAaivPMQDSY...KSDLGSLE.VNNSGITGVGNDQ....IGCYWDWDDddrdmgtDIRALLHEFGD.FGDFFENDAL.PFGEPPGTAESHALMFSgpdcGDILSSP
  329-  399 (108.66/74.95)	QPPPA...PNEEII...SKNQGVM...NNSSL.GLVN........................TSLAFSTSE.FDHIIKAEALmTFAPEFGAVEAPTSELS....SSIFRSP
 1259- 1325 (70.47/29.70)	..........DDSYmqsASSVGSGDaASNSHIDGSDMDKnppsIHCCYGWTE.......DWRWLVCIWTDsRGELLDSQIF.PFG.........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.03|      62|     303|     137|     203|       4
---------------------------------------------------------------------------
  137-  203 (95.37/57.84)	NSNCSSISSISSSSSDSD..YKMNSGANELE....ADADSLTCRQSGLS.SNDQLENDFPrlGSkrPRAgMTDS
  441-  509 (88.66/41.52)	NSNTSTVKPSSSATLQSKnwYTLVESVKDQHdrrsSNNSVVTSEGMGSSiSNINPVNDIK..GA..PRK.IADS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33933 with Med13 domain of Kingdom Viridiplantae
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