<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33921

Description Putative mediator of RNA polymerase II transcription subunit 12
SequenceMQRYHAGGCTSAVNNSTIGGASARDTARADSSSLPANYSLNSRRQPPLTPYKLKCDKEPLNSRLGPPDFHPQTPNCPEETLTKEYVQAGYRETIEGLEEAREISLTQAPTFSKPVVFKCKEAIRKCLRAINESRAQKRKAGQVYGVPLADSLLTKPGVFPEQRPCGEDFRKKWIEGLSQQHKRLRSLVDHVPHGYRKRSLFEVIIRNNVPLLRATWFIKVTYLNQVRPGSVNISSGTSDKAQLSRTELWTKDVIDYLQHLLDEFFAKNHSHSTSHSRDRSTQFLYAGSVHQRSDPVSAGLDIEDSSLHFKWWYMMRLLQWHYADGLILPSLIIDWVLRQLQDKESLEIVQLLLPIIYGVLETVVLSQTYVRSLVGIAVRFIREPSPGGSDLVDNSRKAYTTSALVEMLRYLIVAVPDTFVALDCFPLPSCVVSHVVADGSLSKSSFEDVRKIKIGSSEISVPFRSKGLDAQYQSLALDYVVSSIQKRADSLAKAARPGYPGHSVAKVVEALDRSRVLGDVRGAYTFLFEDLCEGAVNEHWIAEVSPCLRSSLKWIGTVSLSLVCSVFLLCEWATCDFRDFRTAPPDKLKFTGRKDFSQVYIAIRILKLKAEGLQSSCRCKSDNSLGVKTITKSSSQQNSFLARTSMGDLYDLKSNIRNVDQQSMKTSCIFESPGALHDIVVCWIDQHEACKGDGFQRLQLLIVELIRAGIFYPQAYVRQLMVSGIMEMNGSTVDADRRKRHYRILRQLPEFFVRDALQEAGFAEGPQLLEAMHVYANERRLVLSGLICNLNKNLNKTWTLAPKQTIYPTSGKDGASSASVDQWKSIQLSSNVFSGNKVKNDIGIDDLKETISILLQLPNTSSKSTDTGLDEMQLNAKRSSALLFNKMDMGEGTPGCEECKRAKRQKLGEERSLGLQGHSPTLSDEEDTWWVKKGTKSLESFKVDPPLKSSKQVSKNRQKVVRKTQSLAQLQAARIEGSQGASTSHVCDIKVSCPHHRNGIEGETSKSTDGLRTNHCQDVVSIGKELKRLRFVEKRTVSVWLMTVLRQVVEETEKTIAKVGQMGRSFTSVDDRNGIRWKLGEDELSTILYLMDVSNDLVLAVKFVLWLLPKVHGSPNSTIHGGRSSLLLPRNVESQVCEVGEAFLVSSLRRYENILIAQDLIPETLSAAMHHAASVMASNGRVSGSSALVYARYLLKRYGHVASVVEWEKTFKATCDKRLVSELESGRSGDGEVNFPLGVPAGVEDLDDFIRQKISGGRLSRVGANMREIVQRNLNSEDVLQYFFGKERKVFGAGTPKAPVSEKWDDGYQVAQRVIADLMDCIRQTGGAAQEGDPTLVSSAVSAIVGNVGPTIAKLPDFRAVIGYPNFPSATESLNVARRVLRIHISCLSLLKEALGERQTRVFEVALATEASSALAGVFAPGKGSRNQFQLSPDSHDSNSSMSNESLNNSTKVVFTRATKFAAAVSALIVGAVVHGVTSLERMVTVFRLKEGLDVVQFIRSTRSSSNGSSRSIGAFKMDNLIEVYVHWFRLLVGNSRTVTEGLVVELLGEPSIVALSRMQRMLPVALVFPPAYSIFAFVIWRPFILGASLSIREDINQLYQSLMAAISDAIKHLPFRDACLRESQGLYDLVAADNSDADFAAMLELSGSDLHLTSKAFVPLRARLFLNAVIDCKMPGDVNRVSGQGESKTQFAETESKLLNKLVHVLDTLQPAKFHWQWIELRLLLNEQTLVEKLRNHDMSLADAIRSSSPSPGKAAGSENENNFIQIILTRLLVRPDAASLFSDVVHLFGRSLEDSMLLQAKWFLGGADVLLGRKTIRQRLLNIAESDGLPTKAPFWKPWGWFNSGTHPAISGDKKKFESASLEEGEVVEEGTDSKRCRKTFHSESFSSSQQHVTERALVDLLLPCIDQSSDDSRNTFASDLIKQFNNIEQQVNTITRGLDKQAGPTSSGIEGPATKGSNRKVIKGGSPGLARRTTTSAADSALPTPAALRASMLLRLQLLLRLLPVIYADGEPSGKNMRHTLASVILRLLGNRVVHEDVDLSLNHIQHNLSKREVESSTDAASAIITDLSGGSLFDRLLLVLHVLLSGVQPSWLRSKPGPKSTNEYTRDISVIDRELAENLQNDLDRMQLPDMIRWRIQTAMPVLLPSVRCFVNCQPPSIPNAAFASLQPVISNPGSYSGNLITSQRNHFPAARSATNTAGKSKPLPLQDHDTEIDPWTLLEDGAGSGPSSSNSGLIGSGDHANLRASSWLKGAVRVRRKDLTYIGAVDDDN
Length2274
PositionKinase
OrganismMorus notabilis
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Moraceae> Morus.
Aromaticity0.07
Grand average of hydropathy-0.241
Instability index47.01
Isoelectric point8.87
Molecular weight251330.71
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33921
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     267.74|     102|     446|    1534|    1677|       1
---------------------------------------------------------------------------
 1534- 1677 (130.42/165.68)	GNSRTVTEGlvvellGEPSI.....................VALSRMQ...RMLPValVF....PPAYSI...FAFVIWRpfILGASLsIREDINqlyQSLmaaisDAIKHlpfrDACLRESQGlydlvaadNSDADFAAMLELSGSDL........HLTSKAFVP..LRARlflnavidckmPG
 1959- 2101 (137.32/83.66)	GSNRKVIKG......GSPGLarrtttsaadsalptpaalraSMLLRLQlllRLLPV..IYadgePSGKNMrhtLASVILR..LLGNRV.VHEDVD...LSL.....NHIQH....NLSKREVES........STDAASAIITDLSGGSLfdrlllvlHVLLSGVQPswLRSK...........PG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     363.46|     141|     862|     380|     533|       2
---------------------------------------------------------------------------
  272-  436 (208.89/129.06)	STSHSRDRSTQFLYAGSvHQRSDPV.SAGLDIEDSSLHFKwwYMMRLLQwHYADGLI......LPSLIIDWVLRQLQDKESLEIVQLLLPIIYGVLET..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................vvlsqtyvrslvgiavrfIREpSPGGSDLVDNSRKAYTTSALVEMLRYLIVAVPDtFVALDCFP.LPSCVVSHVV
  440-  533 (106.41/76.57)	SLSKSSFEDVRKIKIGS.SEISVPFrSKGLDAQYQSLALD..YVVSSIQ.KRADSLAkaarpgYPGHSVAKVVEALDRSRVLGDVRGAYTFLFEDLCE.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1322- 1376 (48.17/19.58)	..................................................................................................gavnehwiaevspclrsslkwigtvslslvcsvfllcewatcdfrdfrtappdklkftgrkdfsqvyiairilklkaeglqsscrcksdnslgvktitksssqqnsflartsmgdlydlksnirnvdqqsmktscifespgalhdivvcwidqheackgdgfqrlqlliveliragifypqayvrqlmvsgimemngstvdadrrkrhyrilrqlpeffvrdalqeagfaegpqlleamhvyanerrlvlsglicnlnknlnktwtlapkqtiyptsgkdgassasvdqwksiqlssnvfsgnkvkndigiddlketisillqlpntsskstdtgldemqlnakrssallfnkmdmgegtpgceeckrakrqklgeerslglqghsptlsdeedtwwvkkgtkslesfkvdpplksskqvsknrqkvvrktqslaqlqaariegsqgastshvcdikvscphhrngiegetskstdglrtnhcqdvvsigkelkrlrfvekrtvsvwlmtvlrqvveetektiakvgqmgrsftsvddrngirwklgedelstilylmdvsndlvlavkfvlwllpkvhgspnstihggrsslllprnvesqvcevgeaflvsslrryeniliaqdlipetlsaamhhaasvmasngrvsgssalvyaryllkryghvasvvewektfkatcdkrlvselesgrsgdgevnfplgvpagvedlddfirqkisggrlsrvganmreivqrnlnsedvlqyffgkerkvfgagtpkapvsekwddgyqvaqrviadlmdcIRQ.TGGAAQEGDPTLVSSAVSAIVGNVGPTIAKLPD.FRAVIGYPnFPSATESLNV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.06|      25|     446|    1434|    1458|       4
---------------------------------------------------------------------------
 1434- 1458 (41.98/24.94)	DSHDSNSSMSNESLNNSTKVVFTRA
 1875- 1899 (44.07/26.57)	DSKRCRKTFHSESFSSSQQHVTERA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     287.48|      95|     164|     577|     679|       9
---------------------------------------------------------------------------
  577-  679 (139.89/144.49)	FRDFRTAPP....DKLKFTGRKDFSQVYIAIRILKLKAEGLQSSCRCKSDNSLGvKTITKSSSQQnsfLARTSmGDlyDLKSNIrNVDQ.QSMK.TSCIFESPGALHDI
  742-  842 (147.59/117.59)	YRILRQLPEffvrDALQEAGFAEGPQLLEAMHVYANERRLVLSGLICNLNKNLN.KTWTLAPKQT...IYPTS.GK..DGASSA.SVDQwKSIQlSSNVFSGNKVKNDI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33921 with Med12 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GCTSAVNNSTIGGASARDTARADSSSLPANYSLNSR
2) NTITRGLDKQAGPTSSGIEGPATKGSNRKVIKGGSPGLA
3) RNHFPAARSATNTAGKSKPLPLQDHDTEIDPWTLLEDGAGS
8
1935
2189
43
1973
2229










Molecular Recognition Features






MoRF SequenceStartStop




1) IGAVD
2267
2271