<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33909

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAAELGQQTVEFSTLVGRAAEESYLSLKELVEKSRDSDQSDSEKKINILKYLVKTQQRMLRLNVLAKWCQQVPLIQYCQQLASTLSSHDTCFTQAADSLFFMHEGLQQARAPVYDVPSAIEVLLTGSYQRLPKCIEDVGMQSTLNEDEQQPALKKLDTLVRSKLLEVSLPKEISEVKVSDGTALFRINGEFKVLVTLGYRGHLSLWRILHLELLVGERSGLIKLEELRRHALGDDLERRMAAAENPFITLYSVLHELCVALVMDTVIRQVQALRQGRWRDAIKFELISDGSMGHGGSTGSSQINQDGEADTSGLRTPGLKIIYWLDFDKNTGVPDSGSCPFIKIEPGSDLQIKCVHSTFVIDPLTGKEAEFSLDQSCIDVEKLLLRAICCNRYTRLLEIQKVLGKNVQLCRAAGDVVIQSCVDEVDIDSKKKDYKANAREYEEGLEVLRVRAYGSSFFTLGINIRTGRYLLQSSQNIIESSALLECEDALNQGSMNAADVFISLRSKSILHLFASISRFLGLEVYEHGLPAVKLPKNILNGSAMLLLGFPDCGSSYFLLMQLDKDFKPVFKMLETQSELPGKVPSFSNLNQVTRIKKIDIGQMQMLEDEMTLSLLEWGKTHSFLPSAGGTNRISESGLLSDLSLEGSMQIAGGPPSSFSSVVDEVFELERGPSMQNVSSPFNASSRFGSVPVNLHAIKAGTASPKWEGTLQTSQISNFAKVSSGASSYAASLHSPSNLKGSVQTNSLGSLSSIPGRGVAGTKLSASKSEQDLPSLRSPQSAEFGSCTSMDEDQLRLLNDSSKDAIYGRLSQLLSPPLPTGPRVSGSTVKANGPRISPSGPLAGSSKVAGSSSCATPALDYAVCRSPSYDVLSKHEKNPRKRTVSDMLNLIPSLKGVETKGFCKRRKISEVARAQKSSQMLVPMDMVSKTDGYNYGNLIAEANKGNAASSVYVSALLHVVRHCSLCINHARLTSQMEELDIPYVEEVGLRSASSKIWFRLPFSRADTWQHICLRLGRPGSMYWDVKINDQHFRDLWELQKGSNSTPWGSGVRIANTSDIDSHIRYDPEGVVLSYQSVESNSIKKLVADIQRLSNARMFALGMRKLLGVRADEKAEESSSSSDVKAPLSAKGALDAVDRLSEQMRRAFRIEAVGLMSLWFSFGSGVVARFGVEWESGKEGCTMHVTPDQLWPHTKFLEDFINGAEVASLLDCIRLTAGPLHALTAATRPARAGPIPGVPGVAAALSSLPKQAGYLASQGLLPSGVTANVSQGPSSTIGNPASVTAAGPLANHSVHGAAMLAAASRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKHFAVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQELNVLEPSFVGSQQSGGLANNQNQTSGSQLSSANGNRINLPGTAAVSRAGSQVAAFNRMGSVPPGSSNLAVLNTGVPLRRSPGTGVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQQQNSTTAQEELTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLAQAQGGDVAPAQKPRIELCLENHAGLNMDDSSENSSVAKSNIHYDRPHNSVDFALTVVLDPAHIPHINAAGGAAWLPYCVSVRLRYSFGENPNVSFLGMDGSHGGRACWFRVDDWEKCKQRIARTVEGSGSSPGDTNQGRLRLVADNVQRTLNLSLQWLRDGGGVTASSGSTMGSTGGTDYGAHTYENLEREPYWPSEKLRISITGAGGFIASHIARRLKSEGHYIIASDWKKNEHMTEDMFCHEFHLVDLRVMDNCLKVTKDVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMLEAARISGVKRFFYASSACIYPEFKQLETNVSLKESDAWPAEPQDAYGLEKLATEELCKHYTKDFGIECRVGRFHNIYGPFGTWKGGREKAPAAFCRKAITSTDKFEMWGDGLQTRSFTFIDECVEGVLRLTKSDFREPVNIGSDEMVSMNEMAEIVLSFEDKKLPIHHIPGPEGVRGRNSDNTLIKEKLGWAPTMRLKDGLRITYFWIKEQIEKEKTQGVDLSIYGSSKVVGTQAPVQLGSLRAADGKE
Length2195
PositionTail
OrganismMorus notabilis
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Moraceae> Morus.
Aromaticity0.07
Grand average of hydropathy-0.205
Instability index43.60
Isoelectric point7.16
Molecular weight239811.38
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
GDP-mannose 3,5-epimerase activity	GO:0047918	IEA:InterPro
NAD binding	GO:0051287	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33909
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.68|      17|      23|     808|     830|       1
---------------------------------------------------------------------------
  808-  826 (28.97/11.90)	RLSQllSPPLPTGPRVSGS
  834-  850 (30.71/12.25)	RISP..SGPLAGSSKVAGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.13|      22|      23|     627|     649|       2
---------------------------------------------------------------------------
  627-  649 (34.92/23.06)	AGGTNRiSESGLLSD.LSLE.G.SMQ
  651-  675 (28.21/13.44)	AGGPPS.SFSSVVDEvFELErGpSMQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.35|      20|      23|    1488|    1510|       3
---------------------------------------------------------------------------
 1464- 1483 (32.01/15.77)	GTG.VP.AHVRGELNTAIIGLG
 1489- 1510 (26.35/29.60)	GGGwVPlVALKKVLRGILKYLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     164.37|      54|    1001|    1011|    1069|       4
---------------------------------------------------------------------------
  545-  581 (46.82/19.83)	LLLGFPdcGSSYFLLMQLDKDFKPVFKMLETQSELP.G......................
 1012- 1069 (96.09/69.47)	LRLGRP..GSMYWDVKINDQHFRDLWELQKGSNSTPWGSGVRIANTSDIDSHIrydpEGV
 2054- 2073 (21.46/ 6.42)	....................................WGDGLQTRSFTFIDECV....EGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     275.57|     108|     471|    1137|    1279|       5
---------------------------------------------------------------------------
  749-  807 (65.36/26.61)	SLSSIPGRGVagtKLSASKSEQDLPSLRSPQSAEFG........SCT.SMDEDQLRLLNDSSKDAIYG................................................................................
 1137- 1279 (152.90/155.91)	RLSEQMRRAF...RIEAVGLMSLWFSFGSGVVARFGvewesgkeGCTmHVTPDQLWPHTKFLEDFINGaevaslldcirltagplhALTAATRPARagpIPGVpGVAAALSSLPkqagYLASQGLLPS.GVTANVS.QGPSSTIGNPA
 1701- 1754 (57.31/21.22)	......................................................................................ALTVVLDPAH...IPHI.NAAGGAAWLP....YCVSVRLRYSfGENPNVSfLGMDGSHGGRA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.86|      29|      29|     889|     917|       9
---------------------------------------------------------------------------
  889-  917 (47.05/32.88)	LIPSLKGVETKGFCKRRKISEVARAQKSS
  920-  948 (48.81/34.43)	LVPMDMVSKTDGYNYGNLIAEANKGNAAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.55|      20|      28|    1823|    1842|      10
---------------------------------------------------------------------------
 1823- 1842 (38.76/27.87)	TGGTDY.GAHTYENLEREPYW
 1852- 1872 (30.79/20.24)	TGAGGFiASHIARRLKSEGHY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.19|      26|    1547|     396|     469|      11
---------------------------------------------------------------------------
  444-  469 (45.55/108.70)	GLEVLRVRAYGSSFF.TLGINIRTGRY
 1993- 2019 (43.64/ 8.87)	GLEKLATEELCKHYTkDFGIECRVGRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.57|       9|     729|     996|    1009|      12
---------------------------------------------------------------------------
  996- 1009 (15.71/18.05)	WFRLpfsraDTWQH
 1756- 1764 (20.86/ 9.46)	WFRV.....DDWEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.31|      10|     729|    1421|    1444|      14
---------------------------------------------------------------------------
 1408- 1419 (14.08/14.68)	GSQLssANGNRI
 1431- 1440 (19.23/ 7.88)	GSQV..AAFNRM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33909 with Med14 domain of Kingdom Viridiplantae
Unable to open file!