<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33875

Description Protein-lysine N-methyltransferase EFM4
SequenceMTSETSKPSHLDPSALGTKEYWDNLYNREISNHALDATDVGTIWFDDSSAEDKVVDFLNEEIIGKDLLGLGEGRRRGDLSLLDLGTGNGHFLVRLREDEEGDSEEEEGGEEEEGKGIENVGNKWIGRMMGVDYSERSIEFARRIAEDKREEKENEDQADANGKEEPEIEFITWDIMKEDPSPKVLNGKQTKGWDIVLDKGTFDAISLSEETDTNGKRIFEGYKEKVLALVRVGGVAVVTSCNWTEGELIEWFVGKGREEEGERFDVLRKIEYRSFSFGGVKGQTTSINELFVNLDRKPTTVFQTISNYQIARKKWRQSITLIKASWRVSSLQYNSSSPIQATNPLPAAQIKNVIQDLYEIMVQVNNYDNAGRPTRETLEKSLLNLSESLQLVSRITVPAGAPTGTPKIDSVAGKGTDLPWVPADLIQYVDNGRNPDIYTREFVEAARKNNQLMRGKMQAFAGFRDVLAGEMGKVFPELEEDVRMVVEATSYDGEVGK
Length497
PositionMiddle
OrganismSclerotinia borealis (strain F-4128)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Sclerotiniaceae> Sclerotinia.
Aromaticity0.08
Grand average of hydropathy-0.621
Instability index39.57
Isoelectric point4.71
Molecular weight55775.50
Publications
PubMed=24459262

Function

Annotated function S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport. 
GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
protein-lysine N-methyltransferase activity	GO:0016279	IEA:UniProtKB-UniRule
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
vesicle-mediated transport	GO:0016192	IEA:UniProtKB-UniRule









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33875
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.55|      20|      22|     154|     175|       1
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  138-  166 (23.45/ 9.91)	IEFarrIAEDkreekeNEDQADANGKEEP
  168-  191 (31.09/25.04)	IEF...ITWD..imkeDPSPKVLNGKQTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     163.13|      55|     146|      44|     118|       2
---------------------------------------------------------------------------
   58-  118 (84.70/85.73)	LNEE..IIGKDLLglgEGRRRGDLSLLDLGtgnGHFLVRLREDEEGD.SEEEEG.GEEEEG......KGIE
  207-  271 (78.43/40.09)	LSEEtdTNGKRIF...EGYKEKVLALVRVG...GVAVVTSCNWTEGElIEWFVGkGREEEGerfdvlRKIE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.01|      47|      56|     305|     353|       3
---------------------------------------------------------------------------
  305-  353 (77.91/54.27)	ISNYQIARKKWRQsiTLIKASWRVS.SLQYNSSSPIQATNPLPAAQIKNV
  364-  411 (75.11/46.64)	VNNYDNAGRPTRE..TLEKSLLNLSeSLQLVSRITVPAGAPTGTPKIDSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.38|      13|      21|      10|      24|       4
---------------------------------------------------------------------------
   10-   24 (22.81/19.97)	H.LDPSALGTkeYW.DN
   33-   47 (17.57/ 8.46)	HaLDATDVGT..IWfDD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33875 with Med10 domain of Kingdom Fungi
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