<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33875

Description Protein-lysine N-methyltransferase EFM4
SequenceMTSETSKPSHLDPSALGTKEYWDNLYNREISNHALDATDVGTIWFDDSSAEDKVVDFLNEEIIGKDLLGLGEGRRRGDLSLLDLGTGNGHFLVRLREDEEGDSEEEEGGEEEEGKGIENVGNKWIGRMMGVDYSERSIEFARRIAEDKREEKENEDQADANGKEEPEIEFITWDIMKEDPSPKVLNGKQTKGWDIVLDKGTFDAISLSEETDTNGKRIFEGYKEKVLALVRVGGVAVVTSCNWTEGELIEWFVGKGREEEGERFDVLRKIEYRSFSFGGVKGQTTSINELFVNLDRKPTTVFQTISNYQIARKKWRQSITLIKASWRVSSLQYNSSSPIQATNPLPAAQIKNVIQDLYEIMVQVNNYDNAGRPTRETLEKSLLNLSESLQLVSRITVPAGAPTGTPKIDSVAGKGTDLPWVPADLIQYVDNGRNPDIYTREFVEAARKNNQLMRGKMQAFAGFRDVLAGEMGKVFPELEEDVRMVVEATSYDGEVGK
Length497
PositionMiddle
OrganismSclerotinia borealis (strain F-4128)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Sclerotiniaceae> Sclerotinia.
Aromaticity0.08
Grand average of hydropathy-0.621
Instability index39.57
Isoelectric point4.71
Molecular weight55775.50
Publications
PubMed=24459262

Function

Annotated function S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport. 
ECO:0000256	HAMAP-Rule:MF_03188
GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
protein-lysine N-methyltransferase activity	GO:0016279	IEA:UniProtKB-UniRule
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
vesicle-mediated transport	GO:0016192	IEA:UniProtKB-UniRule

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP33875
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.55|      20|      22|     154|     175|       1
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  138-  166 (23.45/ 9.91)	IEFarrIAEDkreekeNEDQADANGKEEP
  168-  191 (31.09/25.04)	IEF...ITWD..imkeDPSPKVLNGKQTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     163.13|      55|     146|      44|     118|       2
---------------------------------------------------------------------------
   58-  118 (84.70/85.73)	LNEE..IIGKDLLglgEGRRRGDLSLLDLGtgnGHFLVRLREDEEGD.SEEEEG.GEEEEG......KGIE
  207-  271 (78.43/40.09)	LSEEtdTNGKRIF...EGYKEKVLALVRVG...GVAVVTSCNWTEGElIEWFVGkGREEEGerfdvlRKIE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.01|      47|      56|     305|     353|       3
---------------------------------------------------------------------------
  305-  353 (77.91/54.27)	ISNYQIARKKWRQsiTLIKASWRVS.SLQYNSSSPIQATNPLPAAQIKNV
  364-  411 (75.11/46.64)	VNNYDNAGRPTRE..TLEKSLLNLSeSLQLVSRITVPAGAPTGTPKIDSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.38|      13|      21|      10|      24|       4
---------------------------------------------------------------------------
   10-   24 (22.81/19.97)	H.LDPSALGTkeYW.DN
   33-   47 (17.57/ 8.46)	HaLDATDVGT..IWfDD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33875 with Med10 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LVRLREDEEGDSEEEEGGEEEEGKGIENVG
92
121










Molecular Recognition Features






MoRF SequenceStartStop




1) EIEFITWDI
167
175