<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33872

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDLGDQPTNVLFCNNFASIAYEYFETQWQTPSLATTKKHLQDVELAWRKHGALVYYDAKREGIWVFQPSPTSPNKPLDEGDDLLSQANLPTVQGVELSKKDKGTYEPSNLTKSKYMMANSLSTPSSTSSPSPLENAMRNAQNANARAMQANSTQNVYDPAASSPGVKSATSLGDTLAFLKEIHEHFISSVQGSIVYRLCSGHGFIPLNSRTLLFPTESPSKSMAYYQSPKISDNTVTLVNLDISLTSLGTLMIKACSYVTPGLQSISLANPENLLRKLSQGADLWLAPGGNPAKFYSFYDDEQLPGVQPISDLRKYPEDNNWRFHGTTIKSWQSRCIDWLSTKGFDPASIEEGGWMFVQVLKTNYMSSNLDYADMPFPDDGAIVPWPTLLCFRTIRASSVGIQPSSANSFGLVDPLSFAEQWSMNADKQASIMLNRQQERNVLAAAKEQADREAQNLRASGHSAALLEKGNNAGAMYPTPPDAVHNPGGPTPSFDGAVTTPGNPTHLFPHDPEATNPGTSIMNTVDTDHWVTSEQKHRSISNMNFDENDNDNDNLFGDMGGDLFGDTDITDADFNFFDQPDDIQMDPQPGSPVVTSTPAAQHNIIENLSISSKPLAPQPTSQDTIIEDAQWIEDNIQPPALQQRIRLPANDKDVEMRNINDSLGVPAPPRSPPRISAPFDKETVFNQLLKRTSKLSGGSSAFDQVKFEHSLMEIDEKYGSNGRYRYSEEEIKPQLLETHNPTNPESLDRRKSENKSLASDVLAQILNNDSGQYEFEPDNEAEQELANESNSVSDASDFDEALPVGLSAMVRLGMKRKRYFDEGSISSYNAFTGEYEPSAGTPQTILEPQIPIFESDPADWSLAPYFTSPDPDIQPSGLSDLDLVETAQIIADQAASGNLRVHDRTRQNPDAHAQAIFSTRKMMAGISKATKACLKEIKRCNLRSYLAIQGIPVVNPALRLPPRPMPNPRAAQNPESLKPSNPFLIQPPKLEVRRGDSKLAVLPPAIHFWDNLGLAPFTGNKDVNAICIHPDIVGITENADIFLDQMRGAYESFRFGGHDRIVFPGSPSSLIHYPFEGNDRESINVNNPVYLSSLKEIMARLSKKLSSMTTEEKNIVVYFIYPVDNSSLLVHICAAFKQLFRFYRRSLSEKKLKAVNELVLQLIPLDFVAAPNSLVVPSPAEYSRLAMEVYDRCVDFASSSTTAAILLEKPLPRTIDFKLSVNPSPALLQENSCLHVAYAQSIDERWITAAWSDNRGTKQMTASYCLGRKNEPFTLFFTDIANEIWETTLDLISSKKVHWRIIIAKTAVMEQSEIEFWTGLASTESNAQISLTLVTVQTDPSLRILPLQIRKSPPTMTSTSQPATTAASTPQASQSSIFSPDNPSTSSRDSTTNAPTPLEAPSTSTPAVPPEPDQNSRLIDLTDQTWGAILSHRLNNSNSLLEFNPALISGYLIKSSGTSSDDPPIVLEVNIIHAEVVGNPRTFHDTLLKEILGYYRGLATLARMRGVVHPVKDGRPWHVAAAEKAVKALYMLV
Length1533
PositionKinase
OrganismSclerotinia borealis (strain F-4128)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Sclerotiniaceae> Sclerotinia.
Aromaticity0.08
Grand average of hydropathy-0.414
Instability index48.05
Isoelectric point5.13
Molecular weight169055.80
Publications
PubMed=24459262

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP33872
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.42|      16|      45|     261|     276|       2
---------------------------------------------------------------------------
  261-  276 (28.98/17.71)	PGLQSIS.LAN.PE.NLLR
  305-  323 (19.44/ 9.10)	PGVQPISdLRKyPEdNNWR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.00|      39|      45|    1300|    1341|       3
---------------------------------------------------------------------------
 1300- 1341 (60.24/43.43)	RII...IAKTAVMEQSEIEFWTGLASTESNAQISltlVTVQTDPS
 1343- 1384 (62.77/37.96)	RILplqIRKSPPTMTSTSQPATTAASTPQASQSS...IFSPDNPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.93|      22|      29|     465|     488|       4
---------------------------------------------------------------------------
  465-  488 (33.42/25.74)	ALLEKGNNAgAMYPTPPDAVhNPG
  497-  518 (44.51/24.52)	AVTTPGNPT.HLFPHDPEAT.NPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.12|      28|      48|     598|     625|       5
---------------------------------------------------------------------------
  598-  625 (49.72/32.13)	PAAQH.....NIIENLSISSKPLAP....QPTSQDTI
  648-  684 (39.40/23.45)	PANDKdvemrNINDSLGVPAPPRSPprisAPFDKETV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     174.01|      55|     472|     374|     440|       6
---------------------------------------------------------------------------
  374-  440 (77.36/82.69)	DMP.FPDDGAivPWpTLLCFRTirASSVGIQPSsansfGLVDpLSFAEQWSMNADKQASIMLnRQQER
  849-  904 (96.65/59.82)	QIPiFESDPA..DW.SLAPYFT..SPDPDIQPS.....GLSD.LDLVETAQIIADQAASGNL.RVHDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.40|      14|      15|     107|     121|       7
---------------------------------------------------------------------------
  107-  121 (21.00/13.46)	PSNlTKSKYMMANSL
  124-  137 (25.41/12.30)	PSS.TSSPSPLENAM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.80|      20|      43|    1177|    1197|       8
---------------------------------------------------------------------------
 1177- 1196 (37.49/20.44)	PSPAEYSRLAME.VYDRCVDF
 1198- 1217 (20.65/ 9.28)	.SSSTTAAILLEkPLPRTIDF
 1223- 1236 (25.66/10.15)	PSPA....LLQE...NSCLHV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.87|      41|      46|     699|     743|       9
---------------------------------------------------------------------------
  699-  743 (63.62/59.00)	SsaFDQVKFEHSLMEID..EKYGSN..GRYRYSEEEIKPQllETHNPTN
  746-  790 (58.25/40.98)	S..LDRRKSENKSLASDvlAQILNNdsGQYEFEPDNEAEQ..ELANESN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.01|      11|      17|     556|     566|      10
---------------------------------------------------------------------------
  556-  566 (21.82/13.60)	FGDMGGDLFGD
  576-  586 (22.18/13.96)	FFDQPDDIQMD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     326.85|     106|     443|     952|    1067|      11
---------------------------------------------------------------------------
  952- 1067 (169.54/113.26)	PVVNPALRLPPRPmPNPRaaQNPE..SLKPSNPFLIQPPKLEvrRGDSKLAvLPPAI...HFWDNLGLA....PFTgnKDVNaiCIHPDIVGITEN.ADIFLDQMRGAYESFRFGGHDR.IVFP...GSP
 1397- 1516 (157.31/80.82)	PLEAPSTSTPAVP.PEPD..QNSRliDLTDQTWGAILSHRLN..NSNSLLE.FNPALisgYLIKSSGTSsddpPIV..LEVN..IIHAEVVGNPRTfHDTLLKEILGYYRGLATLARMRgVVHPvkdGRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.46|      42|     140|     183|     225|      12
---------------------------------------------------------------------------
  183-  225 (71.36/47.77)	HEHFISSVQGSIVYRLcSGHGFIP..LNSRTLLF....PTESPSKSMAY
  325-  372 (72.10/42.96)	HGTTIKSWQSRCIDWL.STKGFDPasIEEGGWMFvqvlKTNYMSSNLDY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33872 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALRLPPRPMPNPRAAQNPESLKPSNPFLIQPP
2) GRYRYSEEEIKPQLLETHNPTNPESLDRRKSEN
3) ILPLQIRKSPPTMTSTSQPATTAASTPQASQSSIFSPDNPSTSSRDSTTNAPTPLEAPSTSTPAVPPEPDQNSRLIDL
4) LEKGNNAGAMYPTPPDAVHNPGGPTPSFDGAVTTPGNPTHLFPHDPEATNPGTSIMNTVDTDHWVTSEQKHRSISNMNFDENDNDNDNLFGDMGGDLF
5) MLNRQQERNVLAAAKEQADREAQNLRASGHSAA
6) MMANSLSTPSSTSSPSPLENAMRNAQNANARAMQANSTQNVYDPAASSP
7) NDSGQYEFEPDNEAEQELANESNSVSDASDF
8) TDITDADFNFFDQPDDIQMDPQPGSPVVTSTPAAQHNIIENLSISSKPLAPQPTSQDTIIEDAQWIEDNIQPPALQQRIRLPANDKDVEMRNINDSLGVPAPPRSPPRISAPFDKET
957
722
1344
467
433
116
768
567
988
754
1421
564
465
164
798
683










Molecular Recognition Features






MoRF SequenceStartStop




NANANA